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Medicine composition of compound saikosaponin D and application of medicine composition

A technology of saikosaponin and composition, which is applied in the field of medicine to achieve the effects of enhancing anti-hepatic fibrosis, inhibiting lipid peroxidation, and protecting and stabilizing

Inactive Publication Date: 2015-06-10
SHANDONG ACAD OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The composition of saikosaponin D and taurine is used to improve the anti-progression of hepatitis and specific and non-specific fatty liver caused by viruses, bacteria, pathogenic microorganisms, drug damage and immune-mediated damage. Hepatic fibrosis, anti-tumor, especially liver cancer has no report and patent disclosure

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Embodiment 1 Preparation of the composition tablet of the present invention

[0029] 1. Prescription:

[0030] Prescription 1

[0031] Saikosaponin D 1g taurine 100g microcrystalline cellulose 50g pregelatinized starch 100g 10% PVPK30 ethanol solution Appropriate amount Magnesium stearate 3g co-preparation 1000 pieces

[0032] Prescription 2

[0033] Saikosaponin D 3g taurine 200g microcrystalline cellulose 60g pregelatinized starch 100g 10% PVPK30 ethanol solution Appropriate amount Magnesium stearate 3g co-preparation 1000 pieces

[0034] 2. Preparation process:

[0035] Raw materials and auxiliary materials were crushed through 80-mesh sieve for later use; preparation of granulation solution: take PVP K30 and add medicinal ethanol with a concentration of 30-95% to make a 5-10% solution; mix raw materials and auxiliary materials, and add appropriate amount of gr...

Embodiment 2

[0036] Embodiment 2 The preparation of the capsule of pharmaceutical composition of the present invention

[0037] 1. Prescription:

[0038] Prescription 1

[0039] Saikosaponin D 0.5g taurine 100g microcrystalline cellulose 50g pregelatinized starch 100g 10% PVPK30 ethanol solution Appropriate amount Magnesium stearate 3g co-preparation 1000 capsules

[0040] Prescription 2

[0041] Saikosaponin D 2g taurine 200g microcrystalline cellulose 60g pregelatinized starch 100g 10% PVPK30 ethanol solution Appropriate amount Magnesium stearate 3g co-preparation 1000 capsules

[0042] 2. Preparation process:

[0043] Raw materials and auxiliary materials were crushed through 80-mesh sieve for later use; preparation of granulation solution: take PVP K30 and add medicinal ethanol with a concentration of 30-95% to make a 5-10% solution; mix raw materials and auxiliary materials, and ad...

Embodiment 3

[0044] Embodiment 3 Preparation of pharmaceutical composition granules of the present invention

[0045] 1. Prescription:

[0046] Prescription 1:

[0047] Saikosaponin D 1g taurine 200g powdered sugar 1000g 2%HPMC50% ethanol solution Appropriate amount co-preparation 1000 packs

[0048] Prescription 2:

[0049] Saikosaponin D 3g taurine 300g powdered sugar 1200g 2%HPMC50% ethanol solution Appropriate amount co-preparation 1000 packs

[0050] 2. Specific steps:

[0051] Crush the raw materials and auxiliary materials through a 100-mesh sieve, and set aside; weigh the raw materials and auxiliary materials according to the prescription amount, mix the raw materials and powdered sugar in equal amounts, add an appropriate amount of 2% HPMC50% ethanol solution, and stir evenly to prepare Suitable for soft materials, pass through a 20-mesh sieve to granulate, dry at 60°C, pass through a 18-mesh sie...

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PUM

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Abstract

The invention discloses a medicine composition for preventing and treating hepatic fibrosis, tumors and especially liver cancer. The medicine composition comprises saikosaponin D and taurine, and is prepared by supplementing conventional medicinal auxiliary materials by virtue of a conventional process. According to the medicine composition disclosed by the invention, taurine has synergistic action on the anti-hepatic-fibrosis performance of saikosaponin D, and can also be used for improving the anti-tumor especially anti-liver-cancer effects of saikosaponin D.

Description

technical field [0001] The invention relates to a pharmaceutical composition composed of saikosaponin D and taurine in a certain proportion and a preparation method thereof, and the use of the pharmaceutical composition in the preparation of medicines for treating and / or preventing liver fibrosis, tumors, especially liver cancer The application belongs to the technical field of medicine. Background technique [0002] Bupleurum is bitter and cool in nature and taste, enters the liver and gallbladder meridian, reconciles exterior and interior, soothes the liver, and promotes yang. Treatment of alternating cold and heat, chest fullness and hypochondriac pain, bitter mouth and deafness, headache and dizziness, malaria, prolapse of the anus, irregular menstruation, and prolapse of the uterus. Modern pharmacological studies have shown that Bupleurum has various pharmacological activities such as anti-inflammation, immune regulation, anti-hepatic fibrosis and liver protection. S...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P1/16A61P35/00A61K31/185
Inventor 孙蓉李晓宇李晓骄阳毛近隆刘闰平冯群
Owner SHANDONG ACAD OF CHINESE MEDICINE
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