Preparation method for creatine nitrate

Abstract

The invention discloses a preparation method for creatine nitrate. The preparation method comprises the following steps: adding water and creatine monohydrate into a reaction container, and stirring and mixing at a temperature lower than 20 DEG C; then, adding nitric acid into the reaction container and controlling the reaction temperature to be lower than 40 DEG C, filtering reaction liquor after the reaction liquor is clarified, cooling the filtered reaction liquor to be lower than 5 DEG C within 0.5-1.5 hours under stirring, standing for 0.5-1.5 hours, centrifuging to separate out mother liquor and creatine nitrate wet crystals; drying the creatine nitrate wet crystals for 5-7 hours under reduced pressure at a temperature lower than 55 DEG C to obtain the creatine nitrate, and replacing mother liquor with water as raw materials for producing next batch of the creatine nitrate. According to the preparation method disclosed by the invention, the creatine nitrate with purity of 99.8% and creatinine lower than 30PPM and without creatine dinitrate and trinitrate can be obtained without re-crystallization, the yield of the creatine nitrate is higher than 83.8%, the energy consumption is reduced, and the cost is low. The whole preparation process is environmentally friendly.

Description

technical field [0001] The invention relates to a preparation method of creatine nitrate. Background technique [0002] It is an indisputable fact that creatine is an important muscle supplement nutrient for the body to improve and enhance muscle performance and strength. At the same time, creatine also has the effect of treating heart disease, enhancing cognitive function and treating asthma. The market demand for it is increasing. However, creatine is not easily soluble in water. This feature seriously affects oral administration and absorption. For this, people have prepared a variety of inorganic acid salts, organic acid salts and esters of creatine. Studies have found that creatine nitrate With good water solubility, it also has the effects of increasing blood vessel relaxation and improving blood circulation after oral administration. [0003] At present, the preparation method of creatine nitrate has been reported in China, such as the published CN102391157A, ...

AI Technical Summary

Problems solved by technology

Furthermore, for the product loss caused by recrystallization, as described in the patent example, 2 moles of anhydrous creatine were added to obtain 186 grams of creatine nitrate, which should theoretically be 388 grams, and the yield was less than 50%.

Due to the small amount of water, the reaction product is in a supersaturated state in the solution, and crystals are precipitated under heat preservation, which is not conducive to the formation of pure crystals.

When the mother liquor is used instead of pure water and creatine monohydrate to form a suspension, nitric acid is added after reheating to carry out the synthesis reaction, and the above disadvantages are more likely to be revealed.