Application of syringaldehyde to preparation of radiocancerogenesis protection drug

A radiation carcinogenic and syringaldehyde technology, which is applied in the application field of syringaldehyde in the preparation of radiation carcinogenic protective drugs, can solve the problems of reducing the radiation carcinogenic effect rate, lack of medical protection measures, and affecting the combat effectiveness of troops, so as to reduce the proportion of primitive cells, Reduce the proliferation of bone marrow tissue, the effect of small toxicity

Inactive Publication Date: 2015-06-17
INST OF RADIATION MEDICINE ACAD OF MILITARY MEDICAL SCI OF THE PLA
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  • Abstract
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Problems solved by technology

The radiation carcinogenic effect recognized by international organizations is a linear and threshold-free theoretical model, which means that even low-dose radiation has the risk of genetic damage effects and carcinogenic effects, as well as psychological damage, which will also affect the combat effectiveness of troops
At present, there is still a lack of effective medical protective measures against the carcinogenic effects of nuclear radiation. Therefore, looking for radioprotective drugs that can effectively reduce the rate of carcinogenic effects of radiation is especially important for workers who have been exposed to a certain dose of radiation for a long time and for cancer patients who have received radiotherapy for secondary carcinogenesis. important

Method used

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  • Application of syringaldehyde to preparation of radiocancerogenesis protection drug
  • Application of syringaldehyde to preparation of radiocancerogenesis protection drug
  • Application of syringaldehyde to preparation of radiocancerogenesis protection drug

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Embodiment 1

[0031] Embodiment 1, syringaldehyde is to the protective effect of γ-ray irradiation animal (mice)

[0032] 1. Syringaldehyde improves the signs of irradiated mice

[0033] Firstly, a radiation carcinogenic animal model was established, and 7-8 week old male BABL / C mice (body weight 25±2g) were selected and randomly divided into three groups. Irradiated control group (100 rats), irradiated syringaldehyde (100 mg / kg) administration group (100 rats) and non-irradiated control group (50 rats). There are two treatment methods. One is to uniformly irradiate the whole body of the animal with cobalt-60 γ-ray source from the Academy of Military Medical Sciences. The absorbed dose is 1.75Gy each time. The cumulative absorbed dose was 7.0Gy. Syringaldehyde was irradiated 0.5h after intragastric administration, and the simple irradiation group was given the same volume of 0.5% sodium carboxymethylcellulose aqueous solution, respectively, before each irradiation. To investigate the eff...

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Abstract

The invention discloses a novel application of syringaldehyde to preparation of drugs. The novel application of the syringaldehyde to preparation of drugs is application of syringaldehyde to preparation of a radiocancerogenesis protection drug. The radiological protection drug with syringaldehyde which serves as an active component has the following advantages that the drug is low in toxicity and free of obvious adverse reactions, the treatment effect is obvious, the drug is administrated by a dosage of 10mg per mouse in 30 minutes before radiation, the low-dosage radiation accommodation adsorption is 7Gy, the occurrence rate of spleen neoplasms of the mouse is reduced by 20%, the occurrence rate of tumors of liver is reduced by 15% and the occurrence rate of thymic tumor is reduced by 24% after radiating for 15 months, the injury to the animal hemopoietic system caused by radiating can be effectively protected under the concentration of 100mg / Kg, the myeloid erythroid ratio and the original cell ratio of the radiated mouse bone marrow are reduced, and the spleen, the liver and the thymus of the radiated animal are protected. The properties show that the syringaldehyde takes a unique role in the radiating and reducing the occurrence of the cancer; the syringaldehyde has a wide application prospect in the national defense medical field.

Description

technical field [0001] The invention relates to the application of syringaldehyde in the preparation of radiocarcinogenic protective drugs. Background technique [0002] The application of nuclear energy in the national economy and military fields is becoming more and more extensive, and the potential harm of ionizing radiation or nuclear radiation to human beings is also increasing. Radiation-induced carcinogenesis is one of the main forms of radiation damage and health hazards. It is a random effect and has a serious impact on human health and life. In some special combat readiness and battlefield environments in the national defense field of our country, such as the army’s underground tunnels, nuclear-powered submarines, the daily installation and maintenance of nuclear weapons of the Second Artillery Force, storage management, special equipment transportation and combat readiness training, there will be a large number of scientific research personnel and training personn...

Claims

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Application Information

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IPC IPC(8): A61K31/11A61P39/00A61P35/00
Inventor 周平坤关华王豫刘晓丹宋曼
Owner INST OF RADIATION MEDICINE ACAD OF MILITARY MEDICAL SCI OF THE PLA
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