Compound, as well as preparation method and application thereof

A technology of compounds and concentrates, applied in the field of compounds and their preparation, can solve problems such as systematic research that has not been reported

Active Publication Date: 2015-06-17
JIANGSU KANION PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The total phenolic fraction of dragon's blood is the main component of dragon's blood, but no systematic research on its material basis has been reported

Method used

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  • Compound, as well as preparation method and application thereof
  • Compound, as well as preparation method and application thereof
  • Compound, as well as preparation method and application thereof

Examples

Experimental program
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preparation example Construction

[0039] The present invention also provides a preparation method of a compound of formula (I), comprising:

[0040] 1) Carry out chromatographic separation of dragon's blood through a macroporous adsorption resin column, elute with an aqueous solution of alcohol of the first mass concentration, and an aqueous solution of alcohol of the second mass concentration, and collect the eluted part of the aqueous solution of alcohol of the second mass concentration eluent,

[0041] The alcohol is C1~C6 alcohol,

[0042] The aqueous alcohol solution of the first mass concentration is an aqueous alcohol solution of 20% to 60%,

[0043] The aqueous alcohol solution of the second mass concentration is an aqueous alcohol solution of 80% to 98%;

[0044] 2) concentrating the eluate obtained in step 1) to obtain the concentrate of the elution site of the second mass concentration of the aqueous solution of alcohol;

[0045] 3) The condensate obtained in step 2) is subjected to chromatograph...

Embodiment 1

[0068] 10g of Longxue Tongluo Capsule bulk drug was dissolved in 40% ethanol and sampled, separated by HP-20 macroporous adsorption resin chromatographic column, eluted successively with 2L 40% alcohol aqueous solution, 2L 95% alcohol aqueous solution, and collected 95 The obtained eluate was eluted with an aqueous solution of % alcohol, and the recovered eluate was concentrated to dryness to obtain a concentrate (Extract I).

[0069] Dissolve the extract I with a small amount of methanol for LH-20 gel separation, the eluent is methanol, automatically receive 1 part (2mL) every three minutes, collect 30 components in total, combine components 11-14 and record them as group Fraction A was concentrated to dryness.

[0070] Component A was dissolved in a small amount of methanol and then separated by LH-20 gel again. The eluent was methanol, and 1 part (2 mL) was automatically received every three minutes. A total of 30 components were collected, and each component A-1~A was conc...

Embodiment 2

[0075] 10g of total phenols of dragon's blood were dissolved in 40% ethanol, separated by HP-20 macroporous adsorption resin column, followed by 1.5L 20% methanol water solution, 1.5L 40% methanol water solution, 1.5L 60% methanol water solution, 1L 90 % methanol aqueous solution for elution, collect the eluate obtained from 90% alcohol aqueous solution elution, recover the eluate and concentrate to dryness to obtain a concentrate (Extract I).

[0076] Dissolve the extract I in a small amount of methanol for H separation on silica gel, and use 500 mL of a chloroform:methanol volume ratio of 15:1 solution, 500 mL of a 10:1 solution, 500 mL of a 5:1 solution, and 300 mL of a 2:1 solution as eluents. TLC spot plate UV showed that the developer was chloroform:methanol 5:1, collected and concentrated into five components. Recorded as FrI-1, FrI-2, FrI-3, FrI-4, FrI-5.

[0077] Dissolve the concentrated FrI-4 with a small amount of methanol for H separation on silica gel. The eluen...

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Abstract

The invention provides a compound, as well as a preparation method and an application thereof; the structure of the compound provided by the invention is presented by the formula (I); the compound has the in-vitro inhibiting effect to lipase; and furthermore, animal experiments show that the compound provided by the invention has the effect of reducing blood fat.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a compound and its preparation method and application. Background technique [0002] Dracaena is a resin extracted from the lipid-containing xylem of Dracaena genus Dracaena genus Liliaceae. Its pharmacological effects are mainly promoting blood circulation, dispelling blood stasis, hemostasis, anti-inflammatory and analgesic, etc. It is mostly used clinically to treat ischemic heart disease, uterine Fibroids, upper gastrointestinal bleeding and other diseases. [0003] Hyperlipidemia and lipid metabolism disorders are the main risk factors for atherosclerosis (AS). Atherosclerosis refers to the deposition and necrosis of lipids, carbohydrates and blood components in the aorta and medium arteries (such as the brain, kidney, and coronary intima) to form atherosclerosis, the proliferation, calcification and hardening of smooth muscle cells and collagen fibers, and the formation o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D311/58A61K31/353A61P3/06A61P3/04
CPCC07D311/58
Inventor 萧伟孙林孟兆青李孟璇刘丽萍杨彪黄文哲丁岗王振中
Owner JIANGSU KANION PHARMA CO LTD
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