Unlock instant, AI-driven research and patent intelligence for your innovation.

Tissue repair membrane with fiber structure, preparation method, using method and application thereof

A tissue repair and fiber structure technology, applied in fiber processing, textile and papermaking, spinning solution preparation, etc., can solve the problems of reduced fiber membrane porosity, low suture strength, affecting cell growth, etc., and achieve tensile strength. And the elongation at break is improved, the material source is sufficient, and the storage and transportation are simple.

Inactive Publication Date: 2015-06-24
MEDPRIN REGENERATIVE MEDICAL TECH
View PDF8 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the tissue repair membrane obtained by electrospinning, the fibers are piled up, and the force between the fibers is not strong. After the suture thread is pulled through, the fibers are easily separated, so the suture strength is not high.
[0007] At present, some people have used hot pressing to make the fibers tightly bonded. Although the suture strength can be improved to a certain extent, the fiber membrane after hot pressing becomes harder, and the porosity of the fiber membrane becomes smaller, which will affect its tissue repair process. cell growth in

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0053] As a preferred preparation method of the tissue repair membrane of the present invention, electrospinning technology can be used, which specifically includes the following steps:

[0054] (1) Stir and dissolve the fiber material in the corresponding solvent to obtain a uniform fiber material solution;

[0055] (2) Load the fiber material solution obtained in step (1) into an electrospinning injector, and install it in the electrospinning device;

[0056] (3) Construct a turntable receiver and place it in the position of the receiving device in the electrospinning equipment;

[0057] (4) Utilize the turntable receiver in step (3) to draw and receive the filaments produced in the electrospinning process;

[0058] (5) The tissue repair membrane obtained in step (4) is placed and shaped, and part of the residual solvent is evaporated and removed;

[0059] (6) The tissue repair membrane obtained in step (5) is soaked, washed, dried, packaged and sterilized.

[0060] In the above step (1...

Embodiment 1

[0089] (1) Preparation of electrospinning solution: stir and dissolve polylactic acid-glycolic acid copolymer (PLGA) with a molecular weight of 250,000 in trifluoroethanol to form a 9% (mass to volume ratio) electrospinning solution;

[0090] (2) Put the completely dissolved electrospinning solution into the syringe and install it in the electrospinning device; among them, the electrospinning parameters are: advancing speed 6mL / h; positive high voltage: 22kV, negative high voltage: -1kV ; The receiving distance is 19cm;

[0091] (3) The receiving device is a roller, the speed of the receiving roller is 100r / min; the electrospinning device and the receiving device are turned on, and the process is stopped after 4 hours to obtain the polylactic acid-glycolic acid copolymer (PLGA) fiber membrane received by the roller;

[0092] (4) Replace the receiving device with a turntable receiver and place it in the original position of the roller. Turn on the electrospinning device, set the adva...

Embodiment 2

[0103] (1) Preparation of electrospinning solution: Polycaprolactone (PCL) with a molecular weight of 180,000 and gelatin were mixed and dissolved in hexafluoroisopropanol at a mass ratio of 4:1 to form 15% (mass volume Than) the electrospinning solution;

[0104] (2) Put the completely dissolved electrospinning solution into the syringe and install it in the electrospinning device; among them, the electrospinning parameters are: advancing speed 4.5mL / h; positive high voltage: 24kV, negative high voltage:- 3kV; The receiving distance is 21cm;

[0105] (3) The receiving device is a roller, and the speed of the receiving roller is 100r / min; the electrostatic spinning device and the receiving device are turned on, and the processing is stopped after 3.5 hours, to obtain the polycaprolactone (PCL) and gelatin composite fiber film received by the roller;

[0106] (4) Construct a turntable receiver, the turntable can be steplessly adjusted with a speed range of 0~10000r / min, and place it ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a tissue repair membrane with a fiber structure, a preparation method, an application in preparation of a tissue repair product and the tissue repair product produced thereof. Total or partial of the fibers of the tissue repair membrane are bending fibers, wherein the bending fiber has a bending part with the curvature of greater than 1; when a suture line passes through the tissue repair membrane, two ends of the bending fiber are on the same side and are opposite to the suture pulling direction. On the premise that the porosity and the flexibility of the original tissue repair membrane are not changed, compared with the fiber prepared by the routine preparation method, the suture strength of the tissue repair membrane is increased for 0.5-5 times, the breaking elongation and the tensile strength are small increased, and the tissue repair membrane is suitable for the tissue regeneration field with high suture strength such as the skin and the hernia.

Description

Technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a tissue repair membrane with a fibrous structure and a preparation method, use method and application thereof, and the fibers of the tissue repair membrane are curved on a millimeter or larger scale. Background technique [0002] Biotissue engineering and regenerative medicine are a new type of discipline that is developing rapidly in the 21st century: that is, using appropriate biological materials to repair and regenerate damaged parts of body organs or tissues. In the field of clinical medicine, many disciplines use different biomedical materials (Scaffold) as extracellular matrix scaffolds, drug carriers, cell / gene carrying carriers and other functions. Cells migrate, metabolize, and differentiate in the growth environment of the specific three-dimensional space of the scaffold, metabolize to produce their own extracellular matrix, and then form a new tissue struct...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/50D04H1/728D01D1/02D01D5/00
Inventor 詹泽丰徐弢袁玉宇
Owner MEDPRIN REGENERATIVE MEDICAL TECH