Preparation method of 4-iodobiphenyl

[0016] Example 1

[0017] Add 14.52g biphenyl, 11.42g iodine, 272ml acetic acid, 1.22ml concentrated sulfuric acid, 3ml concentrated nitric acid, and 3g Cu-La composite mesoporous SiO in a 500ml reaction flask at room temperature. 2 Slowly raise the temperature to 70°C to start the reaction, control the reaction temperature to 70°C, take a sample of GC and detect that there is no biphenyl in the reaction solution, then continue to stir the reaction for 25 minutes to stop heating; lower the temperature to 40°C, discharge cooling, and centrifuge The crude product is obtained, activated carbon is added to the crude product for decolorization, left to stand, recrystallized with ethyl acetate, filtered and dried to obtain 20.33 g of a pure white product with a purity of 99.5%.

[0018] Example 2

[0019] Add 14.52g biphenyl, 9.13g iodine, 230ml acetic acid, 1.22ml concentrated sulfuric acid, 3ml concentrated nitric acid, 3.5g Cu-La composite mesoporous SiO in a 500ml reaction flask at room temperature. 2 Slowly raise the temperature to 75°C to start the reaction. Control the reaction temperature to 75°C. After sampling the GC to detect that there is no biphenyl in the reaction solution, continue to stir the reaction for 20 minutes to stop heating; lower the temperature to 40°C, discharge cooling, and centrifuge The crude product is obtained, activated carbon is added to the crude product for decolorization, left standing, recrystallized with ethyl acetate, filtered and dried to obtain a pure white product 16.25 with a purity of 99.5%.

[0020] Example 3

[0021] Add 14.52g biphenyl, 13.70g iodine, 300ml acetic acid, 1.22ml concentrated sulfuric acid, 3ml concentrated nitric acid, and 3.8g Cu-La composite mesoporous SiO in a 500ml reaction flask at room temperature. 2 Slowly raise the temperature to 80°C to start the reaction, control the reaction temperature to 80°C, take a sample of GC and detect that there is no biphenyl in the reaction solution, then continue to stir the reaction for 15 minutes to stop heating; cool to 40°C, discharge cooling, centrifuge and filter The crude product is obtained, activated carbon is added to the crude product for decolorization, left standing, recrystallized with ethyl acetate, filtered and dried to obtain a white pure product 21.32 with a purity of 99.5%.