Glipizide sustained release tablet and preparation method thereof

A technology for glipizide and sustained-release tablets, which is applied in the field of glipizide sustained-release tablets and its preparation, can solve the problems such as the limitation of main drug ratio and content, the frequency of administration and the discount of drug safety issues, and achieve patient compliance. The effect of good sex, less drug administration times, and high content of the main drug

Inactive Publication Date: 2015-07-01
KAMP PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The preparation method of the invention is simple, but the use of a large amount of organic solvents and the content limitation of the main drug ratio lead to a great discount in solving the problems of dosing frequency and drug safety.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0028] Glipizide sustained-release tablet prescription weight percent:

[0029] Glipizide 8%, acrylic acid 2% resin hydrochloride, 24% monoglyceride behenate, 5% acrylic resin, 20% hydroxypropyl cellulose, 1% magnesium stearate, appropriate amount of water.

[0030] Preparation method: Take prescription amount of acrylic acid No. resin passed through 80 mesh sieve, added to the prescribed amount of hydrochloric acid solution, and continuously shaken to dissolve it completely; take the prescribed amount of piogliflozin, hydroxypropyl cellulose, monoglyceride behenate, and acrylic resin to pass through 30 Mix through a mesh sieve to obtain a solid mixture, sieve the solid mixture with a wet sieve, and dry; grind the granules finely, pass through a 20-mesh sieve for granulation, and dry in an oven at 38°C. The weight loss on drying does not exceed 1.0%. Take magnesium stearate through a 40-mesh sieve and add it to the dried granules, then measure the content, press into table...

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Abstract

The invention discloses a glipizide sustained release tablet and a preparation method thereof. The glipizide sustained release tablet comprises 1-10wt% of glipizide, 35-60wt% of a sustained release material, 1-60wt% of a disintegrating agent and 5-10wt% of a lubricant. The glipizide sustained release tablet has the advantages of uniform drug concentration, good stability and high drug concentration through repeatedly proportioning, carrying out a strict preparation process, using a sieve with a specific mesh and strictly controlling the temperature and the tablet weight, so the administration frequency is reduced, and the compliance of patients is enhanced.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a glipizide sustained-release tablet and a preparation method thereof. Background technique [0002] Diabetes has become the third major disease that seriously endangers human health after cardiovascular and cerebrovascular diseases and malignant tumors. There are about 30 million diabetic patients in my country, of which type II accounts for more than 90%. According to the latest reports of foreign analysts, the prevalence of diabetes worldwide and the rapid development of new drugs for treating type I and type II diabetes will increase the market for diabetes drugs by 16% every year. Sulfonylureas (SU) are oral hypoglycemic drugs with the earliest application, the largest variety, and the most extensive clinical application. Among them, glipizide has the fastest development speed. Since the second half of 2003, the product’s The sales surpassed the once ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/28A61K31/64A61P3/10
Inventor 曾培安周群吴健民贺莲张静刘娟
Owner KAMP PHARMA
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