Microstructured devices for producing monodisperse droplets and bubbles and methods of use thereof

A microstructure, monodisperse technology, applied in chemical instruments and methods, laboratory containers, laboratory utensils, etc., can solve the problems of complex fabrication of hydraulic focusing channels, difficult stable operation, instability, etc., to achieve structural Simple, easy-to-adjust, and mass-produced effects

Active Publication Date: 2016-11-23
TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the fabrication of hydraulic focusing channels is complex and costly, and the jetting flow pattern formed in a symmetrical flow field is affected by hydraulic instability, making it difficult to achieve stable operation in a wide range

Method used

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  • Microstructured devices for producing monodisperse droplets and bubbles and methods of use thereof
  • Microstructured devices for producing monodisperse droplets and bubbles and methods of use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] The width of the main channel with PMMA as the substrate is 1200 microns, the width of the downstream is 750 microns, and the width of the bypass channel is 750 microns. Both the main channel and the bypass channel are square grooves with a depth of 750 microns. A flat-headed quartz capillary with a diameter of 750 microns and an inner diameter of 530 microns is embedded in the bypass channel and protrudes to one side of the main channel with a protruding length of 520 microns. The continuous phase was injected using Teflon tubing and the two-phase fluid was collected. Add sodium dodecyl sulfate (SDS, the mass fraction in the continuous phase is 0.01wt%~2wt%) or cetyltrimethylammonium bromide (CTAB, the mass fraction in the continuous phase is 0.01wt%) ~2wt%) and other aqueous solutions of water-soluble surfactants are used as the continuous phase, and glycerin (mass fraction in the continuous phase is 1wt% ~ 70wt%) is added with different mass concentrations to adjust ...

Embodiment 2

[0044]The width of the main channel with stainless steel as the substrate is 1400 microns, the width of the downstream is 750 microns, the width of the bypass channel is 540 microns, the main channel and the bypass channel are square grooves, and the depth is 540 microns. A stainless steel capillary with an outer diameter of 540 microns and an inner diameter of 310 microns is embedded in the bypass channel and protrudes to one side of the main channel with a length of 520 microns. The continuous phase was injected using Teflon tubing and the two-phase fluid was collected. Add sodium dodecyl sulfate (SDS, the mass fraction in the continuous phase is 0.01wt%~2wt%) or cetyltrimethylammonium bromide (CTAB, the mass fraction in the continuous phase is 0.01wt%) ~2wt%) and other aqueous solutions of water-soluble surfactants are used as the continuous phase, and glycerin (mass fraction in the continuous phase is 1wt% ~ 70wt%) is added with different mass concentrations to adjust the ...

Embodiment 3

[0046] The width of the wide-diameter area of ​​the main channel made of polytetrafluoroethylene is 1400 microns, the width of the narrow-diameter area is 750 microns, and the width of the bypass channel is 540 microns. Both the main channel and the bypass channel are square grooves with the same depth. A stainless steel capillary with an outer diameter of 540 microns and an inner diameter of 310 microns is embedded in the bypass channel and protrudes to the side of the main channel with a length of 520 microns. The continuous phase was injected using Teflon tubing and the two-phase fluid was collected. Add sodium dodecyl sulfate (SDS, the mass fraction in the continuous phase is 0.01wt%~2wt%) or cetyltrimethylammonium bromide (CTAB, the mass fraction in the continuous phase is 0.01wt%) ~2wt%) and other aqueous solutions of water-soluble surfactants are used as the continuous phase, and glycerin (mass fraction in the continuous phase is 1wt% ~ 70wt%) is added with different ma...

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Abstract

The invention belongs to the technical field of fluid micro-dispersion and particularly relates to a micro-structural device for preparing mono-dispersed liquid drops and bubbles and a use method of the micro-structural device. The micro-structural device comprises a substrate, a cover plate and a capillary tube, wherein a step-shaped groove is formed in the substrate; the capillary tube is embedded into the upper half part of the groove, and dispersed phase liquid / air enters a main channel through the capillary tube; a continuous phase is in contact with a dispersed phase at a reducing position of the step structure, and the dispersed phase is sheared into the mono-dispersed bubbles and liquid drops. The micro-structural device is simple in structure, convenient to produce, less prone to blockage and large in operation range, and is not influenced by wettability of the channel; by setting parameters such as two-phase flow, the mono-dispersed liquid drops and bubbles of required sizes can be rapidly and accurately acquired; the micro-structural device is particularly applicable to the preparation of the mono-dispersed liquid drops and bubbles of 1-1000 microns and has good application prospects in fundamental research and practical industry.

Description

technical field [0001] The invention belongs to the technical field of fluid microdispersion, and in particular relates to a microstructure device for preparing monodisperse liquid droplets and air bubbles and an application method thereof. Background technique [0002] Monodisperse droplets and bubbles have a wide range of applications in the food, pharmaceutical, cosmetic, and other chemical industries. In conventional processes, heterogeneous shear flow results in wide droplet and bubble size distributions, which are difficult to utilize efficiently. In the past two decades, the development of microchannel processing technology and microfluidic research has provided new tools for basic research in chemistry, physics, and biology, and has also built a new platform for the preparation of new materials. Based on different channel structures, the researchers prepared monodisperse droplets and bubbles of different sizes. However, in the current work, the formation of smaller...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01L3/00
Inventor 骆广生李严凯徐建鸿王凯
Owner TSINGHUA UNIV
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