Unlock instant, AI-driven research and patent intelligence for your innovation.

Production method of quinapril

A production method and quinapril technology, applied in the direction of peptides and the like, can solve the problems of complex preparation method and high production cost, and achieve the effect of simple preparation process

Inactive Publication Date: 2015-07-01
李磊
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the current process of producing quinapril, the preparation method is complicated and the production cost is high

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0006] The present invention will now be described in further detail.

[0007] The method for producing quinapril of the present invention is characterized in that the specific steps are as follows: compound (I) and compound (II) are condensed to obtain compound (III), and (III) is hydrolyzed with trifluoroacetic acid to obtain After the compound (IV) and (IV) are resolved to obtain their optical isomers, they are then condensed with tetrahydro-3-isoquinazoline carboxylic acid benzyl ester to obtain compounds (V), (V) hydrogenated to remove benzyl Quinapril is obtained by dissolving quinapril in glacial acetic acid containing gaseous hydrogen chloride, stirring for 2h20min, then diluting with xylene and filtering to obtain a double salt. Dissolve this shiny solid in acetonitrile at 60°C. The obtained product was dried at 50° C. under vacuum for 16 h to obtain quinapril.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a production method of quinapril. The method is characterized by comprising the steps are as follows: condensing a compound (I) and a compound (II) to obtain a compound (III); hydrolyzing the compound (III) with trifluoroacetic acid to obtain a compound (IV); splitting the compound (IV) to obtain an optical isomer, condensing with tetrahydro-3-isoquinazoline carboxylic acid benzyl ester to obtain a compound (V), and hydrogenating the compound (V) to remove benzyl, so as to obtain quinapril; dissolving quinapril in glacial acetic acid containing hydrogen chloride gas, stirring for 2h and 20min, then diluting with xylene, and filtering to obtain a double salt; dissolving glossy solid in acetonitrile at 60 DEG C, drying the obtained product in vacuum at 50 DEG C for 16h to obtain quinapril. The production method of quinapril has simple process, and can realize batch production.

Description

Technical field [0001] The invention relates to the field of medicine preparation, in particular to a production method of quinapril. Background technique [0002] Quinapril is a long-acting, oral angiotensin-converting enzyme (ACE) inhibitor without a mercapto group. After oral administration, it is hydrolyzed in the liver into an active diacid compound, namely quinaprilat, which can inhibit ACE and prevent the conversion of angiotensin I to angiotensin II, thereby causing the vasoconstriction mediated by angiotensin II It significantly weakens and reduces the vascular resistance of the arteries; it also inhibits the synthesis of aldosterone, reduces the retention of water and sodium produced by aldosterone, and further reduces blood pressure. Therefore, it is a safe and effective antihypertensive drug. Since it is currently in the process of producing quinapril, the preparation method is complicated and the production cost is high. Summary of the invention [0003] The techni...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C07K5/062
Inventor 李磊
Owner 李磊