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N-pyrimidinyl-norcantharidin amic acid lanthanum (III) complex and preparation method thereof

A technology of lanthanum methyl cantharidin amic acid and methyl cantharidin amic acid, which is applied in the field of N-pyrimidine-demethyl cantharidin amic acid lanthanum complex and its preparation, and achieves reduction of toxicity, easy reaction and improved electric charge. The effect of distribution

Active Publication Date: 2015-07-22
安徽奔马先端科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, due to the certain physiological toxicity of rare earth materials, it is necessary to overcome the physiological toxicity when directly applied to medicine.
[0007] Through searching, at present, there is no literature at home and abroad to improve demethylcantharidin in the direction of combining amide group, rare earth and demethylcantharidin

Method used

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  • N-pyrimidinyl-norcantharidin amic acid lanthanum (III) complex and preparation method thereof
  • N-pyrimidinyl-norcantharidin amic acid lanthanum (III) complex and preparation method thereof
  • N-pyrimidinyl-norcantharidin amic acid lanthanum (III) complex and preparation method thereof

Examples

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Embodiment

[0028] 1.1 Instrument

[0029] Vario EL III elemental analyzer for elemental analysis

[0030] NEXUS-670 Fourier Transform Infrared Spectrometer for Infrared Spectrum Analysis

[0031] TGA / SDTA851 for thermogravimetric analysis e type thermal analyzer

[0032] UV-2501PC UV-Vis Photometer for UV Spectrum Analysis

[0033] DDS-12 Digital Conductivity Meter for Molar Conductance

[0034] Bruker Avanze 400MHz NMR instrument for proton NMR analysis

[0035] PHS-3C acidity meter

[0036] R201D-II rotary evaporator

[0037] Melting point apparatus: Shanghai Precision Scientific Instrument Co., Ltd. WRS-1B digital melting point apparatus

[0038] 1.2 Reagents

[0039] Demethylcantharidin (Sinopharm Group, chemically pure.); 2-aminopyrimidine (A Johnson Matthey Company, analytically pure); rare earth oxide M 2 o 3 (content > 99.9%, China Pharmaceutical Group Shanghai Chemical Reagent Company); lanthanum La (NO 3 ) 3 ·nH 2 O; acetonitrile; absolute ethanol; methanol; THF; d...

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Abstract

The invention discloses an N-pyrimidinyl-norcantharidin amic acid lanthanum (III) complex and a preparation method thereof. A chemical formula of the N-pyrimidinyl-norcantharidin amic acid lanthanum (III) complex is [Ln(HL2)(NO3)(H2O)2](NO3).2H2O, wherein Ln represents lanthanum and HL2 represents an N-pyrimidinyl-norcantharidin amic acid ligand. The N-pyrimidinyl-norcantharidin amic acid lanthanum (III) complex synthesized with the method has relatively strong physiological activity and antioxidation stability.

Description

technical field [0001] The invention belongs to the technical field of chemical synthesis, and specifically refers to an N-pyrimidine-desmethylcantharidin amidate lanthanum (III) complex and a preparation method thereof. Background technique [0002] Cantharidin (cantharidin, CA) is a natural defense toxin widely present in more than 1500 species of cantharidin. Mylabris is an insect belonging to the Cordyceps family. It is cold in nature and pungent in taste. It is a highly toxic Chinese medicinal material. In addition to its anti-cancer activity, it also has various activities such as anti-virus, aphrodisiac, and white blood cell increase. Clinically, cantharidin has shown its unique curative effect in the treatment of cancer and some intractable diseases. However, due to its high toxicity and substantial damage to the heart and kidney organs, the application of cantharidin is greatly limited. Therefore, some cantharidins that selectively inhibit tumor cells, have low tox...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07F5/00A61P35/00
CPCC07F5/003
Inventor 沈丹陈洁
Owner 安徽奔马先端科技有限公司
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