Device and method for rotatably controlling optical tweezers by femtosecond laser

A femtosecond laser and optical tweezers technology, applied in optics, optical components, instruments, etc., can solve the problems of limited particle capture and directional movement, limited application range, thermal damage, etc., and achieve stable rotation manipulation, high precision and stability captured effect

Active Publication Date: 2015-07-22
HEILONGJIANG UNIV
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  • Abstract
  • Description
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  • Application Information

AI Technical Summary

Problems solved by technology

Gaussian beam is a traditional light source of optical tweezers. The best working area of ​​the optical trap formed by Gaussian beam focusing is near the beam focus. In recent years, many scholars have been exploring the use of various laser light sources and designing different optical paths to realize Optical manipulation of various particles and cells, but most technologies are limited to the capture and directional movement of particles, which limits the scope of application; at the same time, the traditional optical tweezers technology improves the capture force of optical tweezers by increasing the incident laser power, Increased capture force causes irreversible thermal damage to the sample

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  • Device and method for rotatably controlling optical tweezers by femtosecond laser

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specific Embodiment approach 1

[0016] Specific implementation mode 1. Combination figure 1 Describe this specific embodiment, a femtosecond laser rotation control optical tweezers device described in this specific embodiment includes a femtosecond pulse laser 1, an aperture 2, an attenuation plate 3, a first 800nm ​​total reflection plane mirror 4, a vortex grating 5. The second 800nm ​​total reflection plane mirror 6, the third 800nm ​​total reflection plane mirror 7, the fourth 800nm ​​total reflection plane mirror 8, the beam splitter 10, the fifth 800nm ​​total reflection plane mirror 11, the microscope 12 and the stage 13,

[0017] The pulsed laser light emitted by the femtosecond pulsed laser 1 enters the attenuation plate 3 through the diaphragm 2, and the attenuation plate 3 attenuates the light intensity of the pulsed laser light and then injects the pulsed laser light into the first 800nm ​​total reflection plane mirror 4, and the first 800nm ​​total reflection The flat mirror 4 totally reflects t...

specific Embodiment approach 2

[0026] Embodiment 2. The difference between this embodiment and the device for controlling optical tweezers by femtosecond laser rotation described in Embodiment 1 is that the femtosecond pulse laser 1 is a titanium-doped sapphire femtosecond laser, and the emitted pulse The laser repetition rate is greater than 70 MHz and the pulse width is 120 femtoseconds.

[0027] In this embodiment, a femtosecond laser is used as the light source of the optical tweezers device. Since the femtosecond laser has high time and space resolution characteristics, it provides a guarantee for improving the capturing power of the optical tweezers. Combining femtosecond laser technology with time-resolved spectroscopy technology, it can also conduct research on ultrafast biological processes in organisms and two-photon fluorescence dynamics. The high time and space resolution characteristics of femtosecond laser can also realize non-invasive local modification of cells.

specific Embodiment approach 3

[0028] Embodiment 3. The difference between this embodiment and the device for controlling optical tweezers by femtosecond laser rotation described in Embodiment 1 is that the stage 13 is a three-dimensional micro-displacement platform.

[0029] The stage 13 described in this embodiment is controlled with high precision by a three-dimensional linear excitation source, and the control accuracy is 50 nm.

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Abstract

The invention provides a device and a method for rotatably controlling optical tweezers by femtosecond laser, and relates to the technical field of optically controlled optical tweezers. By the device and the method, a controlled object can be controlled rotatably in a high-precision, non-contact and scatheless manner. Seed light outputted by a femtosecond laser device passes through a diaphragm, an attenuation slice, total reflection planar mirrors and a vortex grating and then is divided into first-level diffraction light and a zero-level light beam; the first-level diffraction light and the zero-level light beam are reflected via the two total reflection planar mirrors and are coaxially superposed through a beam splitter so as to obtain a light beam with vortex information; the light beam is reflected into a microscope via a reflector so that an optical axis of the light beam is completely superposed to an optical axis of an imaging optical path of the microscope; in the microscope, a femtosecond pulse rotary arm and an imaging optical path of the microscope transmit light reversely, the light is focused via a high power objective lens so as to be converged into a light spot of which the radius is smaller than 1 micrometer, an optical potential well is formed, and objective particles move into the optical potential well and are captured stably and controlled rotatably. The device and the method are suitable for stably capturing grains and cells and rotatably controlling the grains and the cells.

Description

technical field [0001] The invention relates to the technical field of optical manipulation of optical tweezers. Background technique [0002] Since the emergence of optical tweezers technology, optical tweezers have been widely used in life sciences, medicine, physics, materials and nanoscience due to their non-contact and non-destructive manipulation of micro-nano-scale particles, and are considered to be the most ideal single molecule , single cell, particle, micro-nano device manipulation technology. [0003] Optical tweezers mostly use continuous laser and long pulse laser. Compared with continuous laser and long pulse laser, femtosecond laser pulse has extremely short pulse width, high peak power and time and space resolution, and can accurately detect Control action energy. In 2001, Tianjin University proposed the concept of femtosecond laser optical tweezers. Compared with continuous optical tweezers, the optical gradient force acting on particles in femtosecond op...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G02B21/32G21K1/00
CPCG02B21/32G21K1/00
Inventor 冉玲苓迟超王积翔高扬孔德贵吴文智
Owner HEILONGJIANG UNIV
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