Device for regulating erythrocytes in blood vessels of living animals and application of device

A technology for red blood cells and animals, which can be used in therapy, radiation therapy, light therapy, etc., and can solve the problems of reduced control accuracy and stability, poor compatibility, etc.

Active Publication Date: 2020-09-04
JINAN UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the above schemes require invasive implantation of external materials, such as implanting magnetically controlled nanoparticles, ultrasound sources, and metal electrodes into blood vessels as manipulation

Method used

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  • Device for regulating erythrocytes in blood vessels of living animals and application of device
  • Device for regulating erythrocytes in blood vessels of living animals and application of device
  • Device for regulating erythrocytes in blood vessels of living animals and application of device

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[0073] Example 1

[0074] 1. The device of the present invention is built around the scanning optical tweezers system (Tweez250si, Aresis company), such as figure 2 Shown. The laser wavelength is set to 1064nm. First, the outgoing laser will interact with the acousto-optic polarizer to achieve dynamic scanning of the laser focus, with a scanning frequency of 100KHz. After being controlled by the acousto-optic polarizer, the laser beam is broadened by a beam stretching device composed of double lenses, and focused to the sample surface through a 60× water immersion objective lens. During the experiment, real-time observation and video recording were performed through a CCD camera connected to a computer. The requirements of each component in the experimental device are as follows:

[0075] 1) Laser: emits a single-mode laser with a wavelength of 1064nm. The power requirement is continuously adjustable from 0 to 4W;

[0076] 2) Acousto-optic modulator: The outgoing laser is incid...

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Abstract

The invention provides a device for regulating erythrocytes in blood vessels of living animals and an application of the device, and belongs to the technical field of photoelectricity. The device sequentially comprises a laser emitting assembly, an acousto-optic modulation assembly, a beam broadening assembly, a short-wavelength pass dichroic mirror and an inverted objective lens along a laser path, wherein the device further comprises an image input and output assembly, a convex lens, a condenser and a white light emitting assembly on an imaging optical path; and laser emitted from the laseremitting assembly passes through the acousto-optic modulation assembly and the beam broadening assembly in sequence and then irradiates the short-wavelength pass dichroic mirror to change a laser transmission direction, and the laser after changing the transmission direction is focused in a sample chamber through the inverted objective lens. Dynamic scanning of a laser focus is achieved by interaction of the laser emitted from the laser emitting assembly and the acousto-optic modulation assembly, and quasi-static distribution of the laser focus at a plurality of positions can be achieved through fast scanning, so that the device is applied to stable capture, accurate arrangement and rotating manipulation of a plurality of erythrocytes.

Description

technical field [0001] The invention relates to the field of photoelectric technology, in particular to a device for regulating red blood cells and its application. Background technique [0002] As we all know, there is a complex vascular network system in animals, which supplies tissues and organs with fresh oxygen and nutrients through the continuous flow of blood, and at the same time takes away metabolic products such as carbon dioxide to maintain normal physiological balance in the body. In-depth understanding of the physiological mechanism of blood flow, non-contact precise intervention and multifunctional manipulation of blood flow will provide potential ideas and alternatives for further clinical diagnosis and treatment, drug delivery and anti-cancer treatment. [0003] At present, technologies based on magnetic fields, ultrasound, and electric fields have begun to be applied to the dynamic regulation of blood flow. However, the above schemes require invasive implan...

Claims

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Application Information

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IPC IPC(8): A61N5/067
CPCA61N5/06A61N2005/0626A61N2005/0632A61N2005/0664A61N5/067
Inventor 刘晓帅李宝军李宇超高晴张垚
Owner JINAN UNIVERSITY
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