Application of Matrine in preparation of medicine for treating cerebral arterial thrombosis

A technology for ischemic stroke and matrine, which is applied in the application field of matrine for the treatment of ischemic stroke, can solve the problems of lag in clinical treatment drug research, difficult to achieve treatment methods, limited treatment options, etc. The effect of reducing the volume of cerebral infarction, reducing the rate of apoptosis, and improving neurological dysfunction

Inactive Publication Date: 2015-07-29
NINGXIA MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, although many research achievements have been made in the prevention and treatment of cerebral ischemic injury, from the perspective of pathophysiological research, the treatment options are very limited, and the research on clinical therapeutic drugs is relatively lagging behind, making effective treatment methods still difficult to achieve

Method used

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  • Application of Matrine in preparation of medicine for treating cerebral arterial thrombosis
  • Application of Matrine in preparation of medicine for treating cerebral arterial thrombosis
  • Application of Matrine in preparation of medicine for treating cerebral arterial thrombosis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Matrine is used as a medicine for treating ischemic stroke, and the structural formula of matrine is as shown in formula (1):

[0042]

[0043] Among them, ischemic stroke is ischemic stroke in the acute stage, and the single application dose of matrine is limited to the dose that does not cause blood sugar drop. The single application dose of matrine is 7.5mg / kg body weight of mice, and the The dosage form is injection dosage form.

Embodiment 2

[0045] Matrine is used as a medicine for treating ischemic stroke, and the structural formula of matrine is as shown in formula (1):

[0046]

[0047] Among them, ischemic stroke is ischemic stroke in the repair period, and the single application dose of matrine is limited to the dose that does not cause blood sugar drop. The single application dose of matrine is 15 mg / kg body weight of mice, and the dosage form of the drug is It is in powder form for injection.

Embodiment 3

[0049] Matrine is used as a medicine for treating ischemic stroke, and the structural formula of matrine is as shown in formula (1):

[0050]

[0051] Among them, ischemic stroke is ischemic stroke in the repair period, and the single application dose of matrine is limited to the dose that does not cause blood sugar drop. The single application dose of matrine is 30 mg / kg body weight of mice, and the dosage form of the drug is It is in powder form for injection.

[0052] The following animal experiment has further illustrated the effect of above-mentioned embodiment 1-3:

[0053] 1. Experimental materials

[0054] 1.1 Animal handling

[0055]Male ICR mice aged 2-3 months, weighing 25-30 g, were purchased from the Experimental Animal Center of Ningxia Medical University, animal production license number: NCXK (Ning) 2013-0005. Feeding conditions include standard feed, tap water, room temperature maintained at (24±2)°C, humidity 50-60%, and daily light and dark times of 12...

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Abstract

The invention discloses an application of Matrine in preparation of medicine for treating cerebral arterial thrombosis. The experiment result shows that when the Matrine is used within a safe dose range and the dosage is 30 mg / kg bodyweight, certain dosage-efficacy correlation is shown, the volume of cerebral infarction in an ischemia area and the hippocampal neuron apoptosis rate can be reduced, autonomic dysfunction of the focal cerebral ischemia model of a mouse is remarkably relieved, the pathological injury of brain tissue is relieved, the activity of antioxidant enzyme in the brain tissue is improved, and the content of malonaldehyde is reduced. The Matrine has the functions of controlling incidence of cerebral arterial thrombosis, reducing disability and death caused by brain stroke and promoting neural functional recovery.

Description

technical field [0001] The invention relates to the application of matrine, in particular to the application of matrine as a medicine for treating ischemic stroke. Background technique [0002] Stroke is the most common serious neurological disease and has become the third leading cause of death among adults. According to the latest data released by WHO in 2010, approximately 15 million people around the world suffer from stroke every year. In my country, cerebral ischemia (also known as ischemic stroke) has about 2 million new cases and 1.5 million deaths every year. 70% of the survivors have physical disabilities, and 25% have intellectual disabilities, causing a great economic and mental burden to the family and society, and gradually showing a trend of younger people. In recent years, although many research achievements have been made in the prevention and treatment of cerebral ischemic injury, from the perspective of pathophysiological research, the treatment options ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4375A61P9/10
Inventor 余建强赵鹏周茹李玉香郝银菊李南杨文莉刘河涛
Owner NINGXIA MEDICAL UNIV
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