Application of ginsenoside Rg5 in preparation of drug for preventing acute kidney injury

A technology for acute kidney injury and ginsenosides, which is applied in the directions of drug combinations, pharmaceutical formulations, organic active ingredients, etc., to achieve the effects of good industrialization prospects, significant curative effects, and small toxic and side effects

Active Publication Date: 2015-07-29
抚松县安东参业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] So far, there is no report about the protective effect of this compound on acute kidney injury caused by cisplatin (CDDP). The present invention proposes and proves the protective effect of this component on acute kidney injury

Method used

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  • Application of ginsenoside Rg5 in preparation of drug for preventing acute kidney injury
  • Application of ginsenoside Rg5 in preparation of drug for preventing acute kidney injury
  • Application of ginsenoside Rg5 in preparation of drug for preventing acute kidney injury

Examples

Experimental program
Comparison scheme
Effect test

experiment example

[0012] Experimental example. Protective effect of ginsenoside Rg5 on cisplatin (DDDP)-induced acute kidney injury

[0013] 1 Materials and methods

[0014] 1.1 Materials, reagents and instruments

[0015] Ginsenoside Rg 5 , purity >98.5% (HPLC); cisplatin, (CDDP, purity >99%, Pt, 65%, CAS NO. 15663-27-1), Sigma Corporation, USA

[0016] Superoxide dismutase (SOD) kit, bitter creatinine (Cre), blood urea nitrogen (BUN), reduced glutathione (GSH), etc. were purchased from Nanjing Jiancheng Bioengineering Institute; tumor necrosis factor α (TNF- α), interleukin 1β (IL-1β) kits were purchased from American R&D Company, and packaged domestically.

[0017] BP211D electronic balance, Germany Sartorius company; DK-98-1 type electric heating constant temperature water bath, Tianjin Test Instrument Co., Ltd.; HC-2517 high-speed centrifuge, Anhui Zhongke Zhongjia Company; Epoch ultra-micro microplate spectrophotometer , American Boten Instrument Co., Ltd.; FSH-2A adjustable high-...

Embodiment

[0061] Examples Examples of Drugs

[0062] The embodiment one of preparation medicament

[0063] Preparation of capsules 200g of ginsenoside Rg5, appropriate amount of medicinal starch, fully mix the two, pack into capsules, make 1000 capsules, each weighing 0.25g, each containing 200mg of ginsenoside Rg5. Take orally, 4 capsules each time, three times a day.

[0064] The embodiment two of preparation medicament

[0065] Tablet preparation 200g ginsenoside Rg5, appropriate amount of medicinal starch, mix the two thoroughly, use ethanol as a binder to make wet granules, dry, pass through a 120-mesh sieve, pack into capsules, 200 mg per capsule, take 1-2 capsules each time , 2 times a day.

[0066] The embodiment three of preparation medicament

[0067] Preparation of dropping pills polyethylene glycol 4000 300g, melt on a water bath, add 200g of ginsenoside Rg5 raw material, stir evenly, pour into the insulation tube, adjust the constant temperature devi...

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Abstract

The invention discloses an application of ginsenoside Rg5 (C42H70O12, CAS (chemical abstracts service) No. 186763-78-0) in preparation of a drug for preventing CDDP (cis-diamine dichloroplatinum) induced acute kidney injury, and belongs to the field of research and development of medical products. Animal studies show that compared with a module group, ginsenoside Rg5 can reduce the levels of Cre (creatinine) and BUN (blood urea nitrogen) in serum effectively and increase the levels of SOD (superoxide dismutase) and GSH (glutathione) in kidney tissue; besides, ginsenoside Rg5 can obviously inhibit increase of inflammatory factors such as TNF (tumor necrosis factor)-alpha and IL (interleukin)-1beta in the kidney tissue. Therefore, the drug for preventing the acute kidney injury can be prepared from ginsenoside Rg5 and effective ingredients of ginsenoside Rg5. The drug form can adopts any existing dosage forms such as tablets, capsules, powder injections, injections, pills, soft capsules, granules, patches and the like.

Description

technical field [0001] The invention discloses a new application of ginsenoside Rg5 in preparing medicines for preventing acute kidney injury, and belongs to the medical technical field of new biological activities of compounds in traditional Chinese medicines. Background technique [0002] Cisplatin (CDDP) has good curative effect on a variety of tumors, and is one of the most effective and common antineoplastic drugs in clinical use. At present, cisplatin is widely used in clinic as an important chemotherapeutic drug. As a broad-spectrum anticancer drug, cisplatin has a curative effect proportional to the dosage, but at the same time, with the increase of the dosage, the toxicity of the drug also increases, which is likely to cause a variety of adverse reactions, such as gastrointestinal reactions, bone marrow suppression, ear Toxicity, etc., especially its high accumulation, high excretion, and high metabolism in the kidney. Among them, nephrotoxicity is particularly pr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/704A61P13/12
Inventor 李伟王梓关大朋韩烨张桂山杨树宝王英平张瑞唐姗
Owner 抚松县安东参业有限公司
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