Traditional Chinese medicine composition for treating hepatic fibrosis and preparation method and application thereof

Abstract

The invention discloses a traditional Chinese medicine composition for treating hepatic fibrosis and a preparation method and an application thereof, and belongs to the field of traditional Chinese medicines. The traditional Chinese medicine composition comprises the following raw materials in parts by weight: 10 to 20 parts of asiatic moonseed rhizome, 5 to 15 parts of rhizoma arisaematis, and 10 to 20 parts of waternut herb. The traditional Chinese medicine composition has the advantages that according to pharmacological experiment results, the ALT (alanine transaminase), AST (aspertate aminotransferase) and AKP (alkaline phosphatase) contents of serum biochemical indexes of a hepatic fibrosis Kunming mouse can be improved, the Hyp (hydroxyproline) content of the liver tissue is improved, the visceral indexes of spleens, livers and thymus of the hepatic fibrosis mouse model are improved, the HA (hyaluronic acid), LN (laminin), PCIII (type III procollagen) and CIV (type IV collagen) contents of the hepatic fibrosis mouse model are improved, the protein expression levels of TGF-beta 1 (transforminggrowthfactorbeta - beta 1), RLX (raloxifene) and TIMP-1 (tissue inhibitor of metalloproteinase-1) of the liver tissue of the hepatic fibrosis are improved, the super-micro structure of the liver tissue of the hepatic fibrosis is improved, and the obvious influence on the weight of the mouse is avoided; the effect of treating the hepatic fibrosis is obvious, and the toxic effect is avoided.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition for treating liver fibrosis and its preparation method and application, belonging to the field of traditional Chinese medicine. Background technique [0002] Hepatic fibrosis is when the hepatocytes in the liver undergo necrosis and inflammatory stimulation, the proliferation and degradation of extracellular matrix such as collagen between liver cells are out of balance, manifested as excessive collagen hyperplasia or decreased collagen degradation, In turn, it leads to the pathological process of abnormal deposition of fibrous connective tissue between hepatocytes and liver lobules in the liver. A small amount of collagen deposition is called liver fibrosis. A large amount of collagen deposition is accompanied by structural remodeling of liver lobules and formation of pseudolobules. And the formation of special nodules can g...

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Problems solved by technology

[0007] There are many types of drugs for the treatment of liver fibrosis, including TNF-α antagonists, cyclooxygenase inhibitors, antioxidants, TGF-β1

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