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A kind of nifedipine soft capsule and preparation method thereof

A technology of dipine soft capsules and nitrobenzene, which is applied in capsule delivery, pharmaceutical formulations, medical preparations of non-active ingredients, etc., can solve the problems of weakening drug stability and achieve the effect of increasing stability and keeping the appearance from fading

Active Publication Date: 2018-05-15
SHANGHAI SINE WANXIANG PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The invention provides a nifedipine soft capsule and a preparation method thereof, which are used to solve the problem in the prior art that the drug stability is weakened due to the absorption of moisture and pigment in the rubber by the content

Method used

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  • A kind of nifedipine soft capsule and preparation method thereof
  • A kind of nifedipine soft capsule and preparation method thereof
  • A kind of nifedipine soft capsule and preparation method thereof

Examples

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Effect test

Embodiment 1

[0029] Embodiment 1 Weigh the raw materials of the rubber outer layer, the isolation layer and the content layer according to the prescription quantities in Table 1.

[0030] The method for preparing nifedipine soft capsules by weight proportion is:

[0031] (1) Sol: Weigh the prescribed amount of purified water, glycerin, and gelatin and add them into the sol pot in turn, stir and granulate, about 15 to 30 minutes, add the prescribed amount of polyethylene glycol 400, titanium dioxide and pigment, heat and melt under negative pressure for 1.5 ~3 hours, add the prescribed amount of ethylparaben half an hour before discharging. Discharge, put it in an insulated bucket at 45-65°C and keep it warm for later use;

[0032] (2) Prepare the isolation membrane medical solution and the content medical solution of the prescribed amount;

[0033] (3) When pressing pills, spray the isolation membrane medicinal solution prepared in step (2) on the inside of the prepared rubber, dry it wi...

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Abstract

The invention relates to the technical field of medicine and medicine manufacture, in particular to a nifedipine soft capsule and a preparation method thereof. The invention discloses a nifedipine soft capsule, which comprises a rubber outer layer and a content layer, an isolation layer is coated between the outer layer and the content layer, and the isolation layer is sprayed on the inner side of the outer layer. The method of plating an isolation layer between the rubber and the contents prevents the drug from absorbing moisture and pigments in the rubber, thereby increasing the stability of the drug and keeping the appearance of the pill from fading.

Description

technical field [0001] The invention relates to the technical field of medicine and medicine manufacture, in particular to a nifedipine soft capsule and a preparation method thereof. Background technique [0002] Nifedipine is used for the prevention and treatment of angina pectoris caused by coronary heart disease, especially variant angina pectoris and angina pectoris caused by coronary artery spasm. It has no adverse effect on respiratory function, so it is suitable for patients with angina pectoris with obstructive airway diseases, and its curative effect is better than that of beta-receptor antagonists. It is also suitable for various types of hypertension, and has a good effect on intractable and severe hypertension. Because it can reduce afterload, it also has good curative effect on refractory congestive heart failure and is suitable for long-term use. [0003] In the prior art, the contents of nifedipine soft capsules are hygroscopic. After being pressed into fini...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/48A61K31/4422A61K47/38A61K47/10A61P9/10A61P9/12A61P9/04
Inventor 史红顾煜董佳丽顾珽常艳玲卢小玲
Owner SHANGHAI SINE WANXIANG PHARMA
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