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Preparation method of p-bromophenol compound

A kind of technology of phenol compound and p-bromophenol, applied in the field of preparation of p-bromophenol compound, can solve the problem of high cost

Inactive Publication Date: 2015-08-12
QINGDAO INST OF BIOENERGY & BIOPROCESS TECH CHINESE ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

P-bromophenol can also be synthesized by brominating phenol using copper bromide as a brominating agent, but the commonly used brominating agent still needs to develop a more economical and feasible brominating agent due to its high cost

Method used

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  • Preparation method of p-bromophenol compound
  • Preparation method of p-bromophenol compound
  • Preparation method of p-bromophenol compound

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Add manganese acetate (0.87g, 5.0mmol), 48% hydrobromic acid (12.2mL, 110mmol), phenol (9.4g, 100mmol) and n-hexanol (16.3g, 20mL) into a 250mL reactor, mix well, and close Reactor and filled with 30atm air, stirred and heated to 65 o C, after reacting for 1.5 hours, cool to room temperature, take out the mixture for analysis after degassing, and obtain remaining phenol: 2.8g, p-bromophenol: 12.1g.

Embodiment 2-3

[0020] project Catalyst (g, mmol) Phenol (g) p-Bromophenol (g) 1. 0.17，1 3.2 11.2 2. 8.7，50 1.6 14.1

Embodiment 4-8

[0022] Manganese acetate in embodiment 1 is replaced with other transition metal compounds, and the impact on reaction result is shown in the following table:

[0023] project Catalyst (g, mmol) Phenol (g) p-Bromophenol (g) 1. -- 9.2 0.2 2. Vanadium pentoxide (1.82, 10) 5.1 7.2 3. Cobalt nitrate hexahydrate (1.46, 5) 1.5 13.6 4. Iron Phthalocyanine (5.68, 10) 0 12.9 5. Ammonium chloroplatinite (0.37, 1) 9.6 0.4

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Abstract

The present invention provides a preparation method of p-bromophenol compound. The method is characterized in that high selectivity preparation of p-bromophenol is conducted on the raw material phenol compound by using a transition metal catalyst in an oxygen-containing atmosphere.

Description

technical field [0001] The invention relates to a method for preparing p-bromophenol compounds, in particular to a catalyst capable of highly selectively catalyzing phenol compounds to prepare p-bromophenol compounds in an oxygen-containing atmosphere. Background technique [0002] p-Bromophenol is an important organic intermediate widely used in the synthesis of pharmaceuticals, pesticides, dyes, flame retardants and fine chemicals, and can also be used as an additive for plastics and rubber. [0003] There are many methods for preparing p-bromophenol, mainly including direct bromination method, bromination agent bromination method and catalytic bromination method. The direct bromination method mainly uses carbon disulfide as a solvent to obtain p-bromophenol through the reaction of phenol and bromine. Since carbon disulfide is flammable and toxic, many studies have tried to use other solvents instead of carbon disulfide. P-bromophenol can also be synthesized by using c...

Claims

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Application Information

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IPC IPC(8): C07C37/62C07C39/27
CPCC07C37/62C07C39/27
Inventor 安增建万晓波
Owner QINGDAO INST OF BIOENERGY & BIOPROCESS TECH CHINESE ACADEMY OF SCI
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