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Method for detection of transfer volume of phthalic acid ester matters in food package material

A phthalic acid and food packaging technology, applied in material separation, analysis materials, measurement devices, etc., can solve animal teratogenicity, mutagenesis, carcinogenicity and other problems

Inactive Publication Date: 2015-08-12
SHANGHAI ANPEL SCI INSTR +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Animal experiments have shown that the acute toxicity of phthalic acid esters is not great, but in large doses, they have different degrees of teratogenic, carcinogenic and mutagenic effects on animals.

Method used

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  • Method for detection of transfer volume of phthalic acid ester matters in food package material
  • Method for detection of transfer volume of phthalic acid ester matters in food package material
  • Method for detection of transfer volume of phthalic acid ester matters in food package material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0064] Sample preparation and determination methods for 23 phthalates in seasoning powder:

[0065] extract

[0066] Accurately weigh 5.0g (accurate to 0.01g) of mixed uniform solid or semi-solid sample into a 50mL stoppered ground glass test tube, add 5mL of water (water-containing sample, no need to add water), accurately add 15mL of acetonitrile, add 6g of MgSO4 and 1.5g of sodium acetate, vortex for 1min, centrifuge at 4000r / min for 2min, collect the supernatant, and blow with nitrogen at 40°C until nearly dry.

[0067] purify

[0068] After nitrogen blowing, the residue was fixed to 5 mL with acetonitrile, 50 mg PSA purification packing, 50 mg C18 purification packing, 150 mg MgSO4 were added, vortexed for 1 min, centrifuged at 4000 r / min for 2 min, and the supernatant was taken for GC-MS analysis.

[0069] Determination: gas chromatography-mass spectrometry conditions

[0070] a) Chromatographic column: TG / DB-5MS quartz capillary column, 60m×0.25mm (inner diameter), 0...

Embodiment 2

[0084] Sample preparation and determination methods for 23 phthalates in fruit crisps:

[0085] extract

[0086] Accurately weigh 5.0g (accurate to 0.01g) of mixed uniform solid or semi-solid sample into a 50mL stoppered ground glass test tube, add 5mL of water (water-containing sample, no need to add water), accurately add 15mL of acetonitrile, add 6g of MgSO4 and 1.5g of sodium acetate, vortex for 1min, centrifuge at 4000r / min for 2min, collect the supernatant, and blow with nitrogen at 40°C until nearly dry.

[0087] purify

[0088] After nitrogen blowing, the residue was fixed to 5 mL with acetonitrile, 50 mg PSA purification packing, 50 mg C18 purification packing, 150 mg MgSO4 were added, vortexed for 1 min, centrifuged at 4000 r / min for 2 min, and the supernatant was taken for GC-MS analysis.

[0089] Determination: Liquid Chromatography-Tandem Quadrupole Mass Spectrometry Conditions

[0090] Chromatographic column I: Poroshell 120EC-C18 column, 100mm×4.6mm (inner di...

Embodiment 3

[0103] Sample preparation and determination methods of 23 phthalates in egg noodles:

[0104] extract

[0105] Accurately weigh 5.0g (accurate to 0.01g) of mixed uniform solid or semi-solid sample into a 50mL stoppered ground glass test tube, add 5mL of water (water-containing sample, no need to add water), accurately add 15mL of acetonitrile, add 6g of MgSO4 and 1.5g of sodium acetate, vortex for 1min, centrifuge at 4000r / min for 2min, collect the supernatant, and blow with nitrogen at 40°C until nearly dry.

[0106] purify

[0107] After nitrogen blowing, the residue was fixed to 5 mL with acetonitrile, 50 mg PSA purification packing, 50 mg C18 purification packing, 150 mg MgSO4 were added, vortexed for 1 min, centrifuged at 4000 r / min for 2 min, and the supernatant was taken for GC-MS analysis.

[0108] Determination: Liquid Chromatography-Tandem Quadrupole Mass Spectrometry Conditions

[0109] Chromatographic column I: Poroshell 120EC-C18 column, 100mm×4.6mm (inner diam...

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Abstract

The invention discloses a method for detection of transfer volume of phthalic acid ester matters in a food package material, the method includes extraction, namely extraction of a food sample, to be more specific, water, acetonitrile, MgSO4 and sodium acetate are added into the food sample for eddying for 1 min and centrifuging for 2 min in 4000 r / min to obtain a liquid supernatant and a residue, the liquid supernatant is collected, and the residue is blew to dry with 40 DEG C nitrogen; purification, to be more specific, a PSA purification packing, a C18 purification packing and MgSO4are added for eddying for 1 min and centrifuging for 2 min in 4000 r / min, and the liquid supernatant is taken; and determination, to be more specific, gas chromatography and liquid chromatography are used for analyzing to detect the content of the phthalic acid ester matters in the food sample. The present invention provides a reliable, convenient and accurate method for detection of transfer volume of the phthalic acid ester matters in a contact package material.

Description

technical field [0001] The invention relates to a detection method for phthalates in food, in particular to a detection method for the migration and contamination of phthalates in food contact packaging materials. Background technique [0002] Food packaging materials, especially plasticizer phthalates in plastic packaging materials, can migrate and dissolve into food under certain conditions, enter the human body through diet, skin contact, etc., and may pass through the placenta or Milk produces transgenerational effects. Animal experiments show that phthalates have little acute toxicity, but in large doses, they have different degrees of teratogenic, carcinogenic and mutagenic effects on animals. Its subacute toxicity mainly manifests as damage to the kidney, liver, and testis, affecting reproductive function, and inhibiting sperm formation. [0003] EU Directive 2002 / 72 / EC and its subsequent amendments 2004 / 19 / EC and 2005 / 79 / EC stipulate a list of approved plastic raw ...

Claims

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Application Information

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IPC IPC(8): G01N30/02
Inventor 强维曲栗曹辰周瑶邓晓军
Owner SHANGHAI ANPEL SCI INSTR
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