Application of PLGA-PEG-PLGA (poly(lactic acid-glycolic acid)-polyethylene glycol-poly(lactic acid-glycolic acid)) triblock copolymer in medicine loading and slow-release medicine, and preparation method of PLGA-PEG-PLGA triblock copolymer

A PLGA-PEG-PLGA, sustained-release drug technology, applied in non-active ingredients medical preparations, active ingredients-containing medical preparations, drug combinations, etc. Strong sensitivity, the effect of broadening understanding and application

Active Publication Date: 2015-08-26
厦门瑞瓷医疗器械有限公司
View PDF3 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, in the current research on PLGA-PEG-PLGA triblock copolymer hydrogel, most of the studies are on the matching polymerization of small molecular weight PLGA

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of PLGA-PEG-PLGA (poly(lactic acid-glycolic acid)-polyethylene glycol-poly(lactic acid-glycolic acid)) triblock copolymer in medicine loading and slow-release medicine, and preparation method of PLGA-PEG-PLGA triblock copolymer
  • Application of PLGA-PEG-PLGA (poly(lactic acid-glycolic acid)-polyethylene glycol-poly(lactic acid-glycolic acid)) triblock copolymer in medicine loading and slow-release medicine, and preparation method of PLGA-PEG-PLGA triblock copolymer
  • Application of PLGA-PEG-PLGA (poly(lactic acid-glycolic acid)-polyethylene glycol-poly(lactic acid-glycolic acid)) triblock copolymer in medicine loading and slow-release medicine, and preparation method of PLGA-PEG-PLGA triblock copolymer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] The preparation of PLGA-PEG-PLGA triblock copolymer is carried out as follows:

[0033] (1) Weigh a certain amount of PLGA with a known number-average molecular weight, and weigh a corresponding amount of PEG with different molecular weights according to the molar ratio of PLGA and PEG of 2:1 (see Table 1 for the matching of PLGA and PEG molecular weight), and add into a 50mL three-necked flask; wherein, the number average molecular weight of PEG is 3 times that of PLGA, see Table 1 to select and match PLGA (Mn=6600) and PEG (Mn=20000) with gel regions.

[0034] (2) Nitrogen or inert gas was introduced under normal pressure, heated to 160° C. with an electric heating mantle under magnetic stirring, and reacted for 8 hours. Obtain the crude product of PLGA-PEG-PLGA triblock polymer with different molecular weight matching, and cool to room temperature under nitrogen or inert gas atmosphere;

[0035] (3) Dissolve with a certain amount of cold water below 4°C (the amount ...

Embodiment 2

[0039] The difference between this embodiment and Example 1 is that the steps of synthesizing PLGA-PEG-PLGA copolymer are as follows:

[0040] (1) Weigh a certain amount of PLGA with known number-average molecular weight above, and weigh a corresponding amount of PEG with different molecular weights according to the molar ratio of PLGA and PEG of 2:1 (refer to Table 1 for the corresponding matching of PLGA and PEG molecular weight), Add it into a 50mL three-necked flask; wherein, the number average molecular weight of PEG is 3.7 times that of PLGA, see Table 1 to select and match PLGA (Mn=5411) and PEG (Mn=20000) with gel regions.

[0041] (2) Nitrogen or inert gas was introduced under normal pressure, heated to 110° C. with an electric heating mantle under magnetic stirring, and reacted for 18 hours. Obtain the crude product of PLGA-PEG-PLGA triblock polymer with different molecular weight matching, and cool to room temperature under nitrogen or inert gas atmosphere;

[0042...

Embodiment 3

[0046] The difference between this embodiment and Example 1 is that the steps of synthesizing PLGA-PEG-PLGA copolymer are as follows:

[0047] (1) Weigh a certain amount of PLGA with known number-average molecular weight above, and weigh a corresponding amount of PEG with different molecular weights according to the molar ratio of PLGA and PEG of 2:1 (refer to Table 1 for the corresponding matching of PLGA and PEG molecular weight), Add it into a 50mL three-neck flask; wherein, the number average molecular weight of PEG is 4 times that of PLGA, see Table 1 to select and match PLGA (Mn=2000) and PEG (Mn=8000) with gel regions.

[0048] (2) Nitrogen or inert gas is introduced under normal pressure, heated to 230° C. with an electric heating mantle under magnetic stirring, and reacted for 10 h. Obtain the crude product of PLGA-PEG-PLGA triblock polymer with different molecular weight matching, and cool to room temperature under nitrogen or inert gas atmosphere;

[0049] (3) Diss...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
Phase transition temperatureaaaaaaaaaa
Login to view more

Abstract

The invention discloses an application of a PLGA-PEG-PLGA (poly(lactic acid-glycolic acid)-polyethylene glycol-poly(lactic acid-glycolic acid)) triblock copolymer in medicine loading and a slow-release medicine, and a preparation method of the PLGA-PEG-PLGA triblock copolymer. The PLGA-PEG-PLGA triblock copolymer is especially suitable for treatment of periodontitis. A water solution of the PLGA-PEG-PLGA triblock copolymer is subjected to solution-gel phase transformation along with the temperature increment; the phase transformation temperature is 35-39 DEG C; the medicine-loaded water solution of the PLGA-PEG-PLGA triblock copolymer becomes medicine-loaded gel after being injected into a human body; and the medicine-loaded gel is capable of releasing the medicine within 6-8 days. The PLGA-PEG-PLGA triblock copolymer water solution is suitable for application as a medicine carrier and a slow-release medicine.

Description

technical field [0001] The invention relates to the processing of polymer materials, in particular to the use of a PLGA-PEG-PLGA triblock copolymer in drug loading and slow-release drugs and a preparation method thereof. Background technique [0002] The PLGA-PEG-PLGA triblock copolymer formed by the polymerization of polylactic-glycolic acid (PLGA) and polyethylene glycol (PEG) has attracted widespread attention as a research hotspot of biopolymer hydrogel materials due to its excellent properties. . [0003] However, in the current research on PLGA-PEG-PLGA triblock copolymer hydrogel, most of the studies are on the matching polymerization of small molecular weight PLGA and small molecular weight PEG, and there are few studies on large molecular weight, so there are many limitations in practical applications. , yet to be further explored. Contents of the invention [0004] The purpose of the present invention is to solve the above-mentioned problems in the prior art, t...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K9/06A61K47/42A61K45/00A61P1/02A61K47/34
Inventor 林旭敬祥林
Owner 厦门瑞瓷医疗器械有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap