Application of PLGA-PEG-PLGA (poly(lactic acid-glycolic acid)-polyethylene glycol-poly(lactic acid-glycolic acid)) triblock copolymer in medicine loading and slow-release medicine, and preparation method of PLGA-PEG-PLGA triblock copolymer
A PLGA-PEG-PLGA, sustained-release drug technology, applied in non-active ingredients medical preparations, active ingredients-containing medical preparations, drug combinations, etc. Strong sensitivity, the effect of broadening understanding and application
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Embodiment 1
[0032] The preparation of PLGA-PEG-PLGA triblock copolymer is carried out as follows:
[0033] (1) Weigh a certain amount of PLGA with a known number-average molecular weight, and weigh a corresponding amount of PEG with different molecular weights according to the molar ratio of PLGA and PEG of 2:1 (see Table 1 for the matching of PLGA and PEG molecular weight), and add into a 50mL three-necked flask; wherein, the number average molecular weight of PEG is 3 times that of PLGA, see Table 1 to select and match PLGA (Mn=6600) and PEG (Mn=20000) with gel regions.
[0034] (2) Nitrogen or inert gas was introduced under normal pressure, heated to 160° C. with an electric heating mantle under magnetic stirring, and reacted for 8 hours. Obtain the crude product of PLGA-PEG-PLGA triblock polymer with different molecular weight matching, and cool to room temperature under nitrogen or inert gas atmosphere;
[0035] (3) Dissolve with a certain amount of cold water below 4°C (the amount ...
Embodiment 2
[0039] The difference between this embodiment and Example 1 is that the steps of synthesizing PLGA-PEG-PLGA copolymer are as follows:
[0040] (1) Weigh a certain amount of PLGA with known number-average molecular weight above, and weigh a corresponding amount of PEG with different molecular weights according to the molar ratio of PLGA and PEG of 2:1 (refer to Table 1 for the corresponding matching of PLGA and PEG molecular weight), Add it into a 50mL three-necked flask; wherein, the number average molecular weight of PEG is 3.7 times that of PLGA, see Table 1 to select and match PLGA (Mn=5411) and PEG (Mn=20000) with gel regions.
[0041] (2) Nitrogen or inert gas was introduced under normal pressure, heated to 110° C. with an electric heating mantle under magnetic stirring, and reacted for 18 hours. Obtain the crude product of PLGA-PEG-PLGA triblock polymer with different molecular weight matching, and cool to room temperature under nitrogen or inert gas atmosphere;
[0042...
Embodiment 3
[0046] The difference between this embodiment and Example 1 is that the steps of synthesizing PLGA-PEG-PLGA copolymer are as follows:
[0047] (1) Weigh a certain amount of PLGA with known number-average molecular weight above, and weigh a corresponding amount of PEG with different molecular weights according to the molar ratio of PLGA and PEG of 2:1 (refer to Table 1 for the corresponding matching of PLGA and PEG molecular weight), Add it into a 50mL three-neck flask; wherein, the number average molecular weight of PEG is 4 times that of PLGA, see Table 1 to select and match PLGA (Mn=2000) and PEG (Mn=8000) with gel regions.
[0048] (2) Nitrogen or inert gas is introduced under normal pressure, heated to 230° C. with an electric heating mantle under magnetic stirring, and reacted for 10 h. Obtain the crude product of PLGA-PEG-PLGA triblock polymer with different molecular weight matching, and cool to room temperature under nitrogen or inert gas atmosphere;
[0049] (3) Diss...
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