Plant growth regulator-1-methyl propylene effervescent granule/or effervescent tablet and preparation method thereof

A technology of methylcyclopropene and growth regulator, which is applied in plant growth regulators, plant growth regulators, botany equipment and methods, etc. It can solve the problems of less release of active ingredients, inconvenient weighing and use, waste of medicines, etc. , to achieve fast disintegration, good storage stability, and less drug damage

Active Publication Date: 2015-09-02
禾金正生物科技(北京)股份有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Among the published patents in my country, the application number 200610042683.2 discloses a method for preparing its powder preparation by immobilizing 1-methylcyclopropene with α-cyclodextrin and its derivatives as the main inclusion material. The registered preparations are 3.3%, 0.14%, and 0.014% microcapsule granules. The disadvantage of this type of product is tha

Method used

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  • Plant growth regulator-1-methyl propylene effervescent granule/or effervescent tablet and preparation method thereof
  • Plant growth regulator-1-methyl propylene effervescent granule/or effervescent tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Example 1 Preparation of 0.33% 1-methylcyclopropene effervescent granules

[0028] The selection and ratio of the original drug and the adjuvant are: 3.3% 1-methylcyclopropene microcapsule powder 10% (0.33%), of which 3.3% 1-methylcyclopropene microcapsule granules are produced by Beijing Huijinzheng Biotech Provided by Co., Ltd., dispersant is 2.0% sodium methylene dimethyl naphthalene sulfonate, 4.0% calcium lignosulfonate, wetting agent is sodium lauryl sulfate 2.0%, disintegrant is sodium bicarbonate 16.0% , Citric acid 16.0%, binder is starch 5.0%, and filler is attapulgite to make up to 100%.

[0029] Calculate the dosage of each component according to the above ratio, weigh, and mix evenly; the formula is granulated by ultra-micro / air jet pulverization, drying, granulation, and selection. Product testing is conducted in accordance with the quality control standards of effervescent granules. The indicators include active ingredient content, wetting time, disintegratio...

Embodiment 2

[0036] Example 2 Preparation of 0.33% 1-methylcyclopropene effervescent tablet

[0037] The selection and ratio of the original drug and adjuvants are: 3.3% 1-methylcyclopropene microcapsule granules 10% (0.33%), of which 3.3% 1-methylcyclopropene microcapsule granules are produced by Beijing Huijinzheng Biotech Co., Ltd. Provided by Science and Technology Co., Ltd., dispersant is hydrocarbyl naphthalenesulfonate formaldehyde condensate (NNO) 3.0%, calcium lignosulfonate 3.0%, wetting agent is sodium lauryl sulfate 2.0%, disintegrant is sodium bicarbonate 21.0%, citric acid 21.0%, binder is starch 5.0%, and filler is talc to make up to 100%.

[0038] Calculate the dosage of each component according to the above ratio, weigh, and mix evenly; the formula is granulated by ultra-micro / air jet pulverization, drying, tableting, and selection. Product testing is carried out in accordance with the standards of effervescent tablet quality control. The indicators include active ingredient c...

Embodiment 3

[0045] Example 3 Preparation of 0.66% 1-methylcyclopropene effervescent granules

[0046] The selection and ratio of the original drug and adjuvants are: 3.3% 1-methylcyclopropene microcapsule granules 20% (0.66%), of which 3.3% 1-methylcyclopropene microcapsule granules are produced by Beijing Huijinzheng Biotech Co., Ltd. Provided by Technology Co., Ltd., dispersant is 6.0% sodium methylene dimethyl naphthalene sulfonate, wetting agent is sodium lauryl sulfate 3.0%, disintegrant is sodium carbonate 6.0%, sodium bicarbonate 12%, lemon The acid is 18.0%, the binder is sodium carboxymethyl cellulose 3.0%, and the filler is diatomaceous earth to make up to 100%. The specific process is the same as in Example 1.

[0047] The measurement method of each performance index of 1-methylcyclopropene effervescent granules prepared in Example 3 is the same as that in Example 1. The specific measurement results are: 1-methylcyclopropene content 0.66%, wettability qualified (25s), disintegrati...

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Abstract

The invention relates to the technical field of pharmaceutical preparations, and particularly discloses a plant growth regulator-1-methyl propylene effervescent granule/or effervescent tablet and a preparation method thereof. The 1-methyl propylene effervescent granule/or effervescent tablet is prepared from the following raw materials in percentage by mass: 0.01%-20% of 1-methylcyclopropene, 0.5%-15% of a dispersing agent, 0.5%-8% of a wetting agent, 4%-60% of a disintegrating agent, 0-10% of a binder and a filler; and the preparation method comprises the following steps: mixing various raw materials for forming the 1-methyl propylene effervescent granule/or effervescent tablet; and carrying out superfine/airflow smashing, pelletizing, drying, arranging/tabletting, selecting and detecting, so as to obtain the plant growth regulator-1-methyl propylene effervescent granule/or effervescent tablet. The 1-methyl propylene effervescent granule/or effervescent tablet provided by the invention is safe to environment, people, livestock and other beneficial organisms and accurate to meter; a pesticide hazard is not easy to generate; compared with an ordinary encapsulated granule, the 1-methyl propylene effervescent granule/or effervescent tablet is free of dust, high in granular disintegration speed, convenient to use, good in storage stability, and simple in preparation technology and is suitable for industrialized production and large-area popularization and application in the field of preservation of fruits, vegetables and flowers; and effective components can be fully released within the stipulated time during use.

Description

Technical field [0001] The invention relates to an effervescent granule / or effervescent tablet of a plant growth regulator and a preparation method thereof, in particular to a 1-methylcyclopropene granule / or effervescent tablet and a preparation method thereof. Background technique [0002] Ethylene plays an important role in the storage, transportation and preservation of horticultural products. It promotes the ripening, senescence and shedding of fruits, flowers and leaves, and is called "ripening hormone". In order to prolong the storage life of horticultural products and keep them fresh, it is very necessary to inhibit the synthesis of endogenous ethylene in these organs or prevent ethylene from playing a role. [0003] 1-Methylcyclopropene is a cyclic hydrocarbon containing double bonds. It exists in a gaseous state, is odorless, and has no physiological toxicity. A lower concentration has obvious physiological effects. It competes with ethylene for the binding site on the et...

Claims

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Application Information

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IPC IPC(8): A01N27/00A01N25/14A01N25/34A01P21/00
Inventor 吴学民郭鑫宇
Owner 禾金正生物科技(北京)股份有限公司
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