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Method for extracting, separating and purifying costunolide and dehydrocostus lactone from elecampane

A technology for dehydrogenation of woody lactone and woody hydrocarbon lactone, applied in the direction of organic chemistry and the like, can solve the problems of low recovery rate, difficult selection of solvent system, lack of theoretical guidance, etc., and achieves the effect of low comprehensive cost

Inactive Publication Date: 2015-09-02
XUZHOU MEDICAL COLLEGE
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Problems solved by technology

According to literature reports, the methods for separating and purifying the sesquiterpene lactones in Cinnamomum sinensis mainly include repeated silica gel column chromatography and high-speed countercurrent chromatography. The operation process of silica gel column chromatography is cumbersome and the recovery rate is low. , benzene and other highly toxic organic solvents; the choice of solvent system in high-speed countercurrent chromatography is difficult and lacks theoretical guidance

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  • Method for extracting, separating and purifying costunolide and dehydrocostus lactone from elecampane
  • Method for extracting, separating and purifying costunolide and dehydrocostus lactone from elecampane
  • Method for extracting, separating and purifying costunolide and dehydrocostus lactone from elecampane

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Embodiment Construction

[0020] The technical solutions of the present invention will be described in detail below in conjunction with the embodiments and drawings, but the scope of protection is not limited thereto. The equipment or raw materials used in the examples are all available from the market. All the reagents used were purchased from Tianjin No. 3 Chemical Reagent Factory, and the water used was deionized water.

[0021] The method for extracting, isolating and purifying corylidene and dehydrocorylide from woody, the steps are:

[0022] (1) Extraction of sesquiterpene lactones in Cinnamomum sinensis: pulverize the Cinnamomum sinensis medicinal material, heat and reflux extraction with 8 times the amount of 95% ethanol for 3 times, each time for 1h, filter, combine the extracts, concentrate under reduced pressure to obtain crude extract things.

[0023] (2) Separation and analysis of sesquiterpene lactones in Osmanthus fragrans: use analytical high performance liquid chromatography to separ...

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Abstract

The invention discloses a method for extracting, separating and purifying costunolide and dehydrocostus lactone from elecampane, and relates to the technical field of extracting, separating and purifying costunolide and dehydrocostus lactone. With an elecampane medicinal material as a raw material, the method disclosed by the invention comprises the following steps: (1) extracting sesquiterpene lactone in the elecampane; (2) separating and analyzing the sesquiterpene lactone in the elecampane; (3) separating and purifying the sesquiterpene lactone in the elecampane; and (4) detecting the purity of the compound and verifying the structure. Semi-preparative high performance liquid chromatography is used for separating and extracting, the mobile phase is methanol-water, and two components with high purity are obtained, which are respectively costunolide and dehydrocostus lactone as shown in verification. The process flow is environmentally friendly, free of severe harm to the environment and low in comprehensive cost.

Description

technical field [0001] The invention relates to the technical field of extracting, separating and purifying coylin and dehydrocorylides, in particular to a method for extracting, separating and purifying coylin and dehydrocoylide from woody. Background technique [0002] The traditional Chinese medicine Muxiang is the dry root of Aucklandia lappa Decne., a plant of Compositae. It is pungent, warm, and bitter in taste. It returns to the spleen, stomach, large intestine, triple burner, and gallbladder meridian. It is used for the treatment of chest and abdominal pain, vomiting, diarrhea, dysentery, tenesmus, and indigestion. Pharmacological studies have shown that woody wood has good pharmacological activities in anti-cardiovascular disease, anti-inflammation, anti-cancer, anti-ulcer, and anti-pathogenic microorganisms. The study of chemical constituents showed that sesquiterpene lactones were the main active components of xanthus chinensis, among which the content of xylolid...

Claims

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Application Information

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IPC IPC(8): C07D307/93
CPCC07D307/93
Inventor 杨冬芝杨方秀陆益红汤道权樊夏雷
Owner XUZHOU MEDICAL COLLEGE
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