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Biomolecule measuring device

一种生物分子、测量装置的技术，应用在测量装置、生物化学清洗装置、酶学/微生物学装置等方向，能够解决分析时间增大等问题，达到降低测定噪声的效果

Active Publication Date: 2015-09-02
HITACHI HIGH-TECH CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the case of performing parallel measurement using 1 million to more than 1 billion ISFETs like the semiconductor DNA sequencer mentioned above, it is necessary to perform the above-mentioned background processing on the measurement data of all the reaction tanks, and the background processing increases the analysis time

Method used

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Examples

Experimental program
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Embodiment approach 1

[0062] Embodiments of the present invention will be described below using the drawings. Here, an ISFET is used as a semiconductor sensor, and a DNA sequencer for determining the sequence of DNA is used as an example of a biomolecule measuring device. However, the application target of the present invention is not limited to a DNA sequencer, and can be widely used in electrical A system for measuring the reaction products of biomolecules. An ISFET can detect various ions by appropriately selecting an ion-sensitive membrane, and therefore, for example, the present invention can be applied to a device for measuring biomolecules that change sodium ions and potassium ions. In addition, in all the drawings for explaining the embodiment, in principle, the same reference numerals are attached to the same components, and their repeated descriptions are omitted.

[0063] refer again figure 1 . The ISFET array 304 has a plurality of wells 703 arranged two-dimensionally, and the ion-se...

Embodiment approach 2

[0114] In Embodiment 1, it was described that the drift / offset component 1301 and the background 1300 are subtracted from the signal waveform detected by the ISFET 114 by calculation, and only the extended signal 1302 is taken out. In Embodiment 2 of the present invention, another configuration example in which the drift / offset component 1301 and the background 1300 are subtracted will be described.

[0115] Figure 15 It is a circuit diagram extracting one cell and its peripheral circuits on the ISFET array chip 1002 included in the biomolecule measurement device according to the second embodiment. Although not shown, it is actually the same as Figure 9 Likewise, there are a plurality of row selection lines WL, source lines SL, data lines DLA and DLB. Regarding the ISFET 114, only the ion sensitive film 100 and the floating gate 102 are schematically shown, and the protective film 101 is omitted.

[0116] In Embodiment 2, the floating gate 102 is connected to a constant v...

Embodiment approach 3

[0132] In Embodiments 1 and 2, a configuration example in which the signal quality of the ISFET 114 is improved by removing the drift / offset component 1301 and the background component 1300 has been described. In Embodiment 3 of the present invention, a configuration example in which the signal quality of ISFET 114 is improved by other means will be described.

[0133] Figure 18 It is a functional block diagram of the biomolecule measuring device according to the third embodiment. The biomolecule measuring device according to the third embodiment includes an excess solution removing device 315 in addition to the configuration described in the second embodiment. The other configurations are the same as in Embodiment 2, so the following description will focus on differences.

[0134] The excess solution removing device 315 is a device for removing the reagent solution existing outside the well 703 and is controlled by the controller 312 . Residual solution removal device 315...

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Abstract

Provided is a biomolecule measuring device capable of effectively reducing measurement noise occurring when measuring a biomolecule sample using a semiconductor sensor. This biomolecule measuring device generates a trigger to react a sample with a reagent after starting to send the reagent onto the semiconductor sensor that detects ion concentration (see FIG. 7).

Description

technical field [0001] The invention relates to a biomolecule measuring device. Background technique [0002] In recent years, biomolecular measurement devices using semiconductor technology have been attracting attention. Patent Document 1 below describes a DNA sequencer that determines the nucleotide sequence of deoxyribonucleic acid (DNA) at low cost and high speed by using a pH sensor array fabricated by semiconductor technology. Since the semiconductor sensor quantifies the reaction of the target biological substance based on the strength of the electrical signal, it does not require expensive fluorescent reagents as in the past, which is advantageous in terms of cost. In addition, more than a million to one billion sensors can be integrated by semiconductor microfabrication technology, and measurements can be performed by operating each sensor in parallel, so the throughput of measurement can also be easily improved. [0003] As a semiconductor sensor that is particu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/416C12M1/00G01N27/28G01N27/414
CPCG01N27/4145
Inventor 柳川善光横井崇秀板桥直志河原尊之右高园子吉田真希子村松高道
Owner HITACHI HIGH-TECH CORP
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