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Preparation method of panaxadiol sapogenin

A technology of panaxadiol saponin and panaxadiol saponin, which is applied in the field of preparation of panaxadiol saponin, can solve the problems of inconvenient operation, uncontrollable, low conversion rate, etc., and achieve simple and easy process, convenient operation, High conversion effect

Inactive Publication Date: 2015-09-09
许庆彤
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to solve the existing but technically existing defects of ginsenoside saponin preparation process complex, inconvenient operation, unsafe, uncontrollable, poor repeatability, low conversion rate, unsuitable for industrialized large-scale production

Method used

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  • Preparation method of panaxadiol sapogenin
  • Preparation method of panaxadiol sapogenin

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Embodiment Construction

[0019] The present invention will be further described below in conjunction with preferred embodiments of the present invention.

[0020] The preparation method of panaxadiol saponin comprises the following preparation steps:

[0021] (1) Take 220 g of ginseng stem and leaf total saponins, put it into a reaction kettle, add 2200 g of 5 mol / l sodium hydroxide aqueous solution, and react at a constant temperature of 260 ° C for 1.5 hours;

[0022] (2) After the temperature in the kettle is down to room temperature, open the reaction kettle, take out the solid, and add a volume fraction of 95% ethanol to dissolve;

[0023] (3) adding mass fraction is 20% hydrochloric acid ethanol solution to adjust the pH to neutral, filter, concentrate the filtrate, wash twice with deionized water, filter, filter cake is dried under reduced pressure, and the filter cake is dried under reduced pressure, the condition is: pressure-0.05Mpa , temperature 50-60°C;

[0024] (4) Add ethanol with a vo...

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Abstract

The invention provides a preparation method of panaxadiol sapogenin, which comprises the steps of alkalifying, and oxygenating under high pressure and hydrolysizing; and the content of product after refining can reach as high as 80%. The preparation method has the advantages of simple and easy operation, convenient operation, safety and controllability, good repeatability, and high conversion rate, and is adapted to industrial large-batch production. Strict technical condition and quality index can guarantee reliable and consistent quality of panaxadiol sapogenin, and the preparation method can effectively establish a base for controllable quality and safety of a preparation.

Description

technical field [0001] The invention relates to a preparation method of panaxadiol saponin. Background technique [0002] The total saponins of ginseng stems and leaves contain a large amount of ginsenoside Rb 1 , Rb 2 , Rc, Rd and other protopanaxadiol-type saponins can produce panaxadiol saponins through degradation. The initial raw material for the production of ginsengdiol saponins is total saponins from stems and leaves of ginseng, which are total saponins prepared from the stems and leaves of the aerial parts of the Araliaceae plant ginseng (Panax ginseng C.A.Mey.) through extraction, separation, purification, decolorization and other processes. [0003] In the prior art, the preparation process of panaxadiol saponin is complex, inconvenient, unsafe, uncontrollable, poor in repeatability, and low in conversion rate, and is not suitable for large-scale industrial production. Contents of the invention [0004] In order to solve the defects that the preparation proce...

Claims

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Application Information

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IPC IPC(8): C07J9/00
CPCC07J9/00
Inventor 赵树民王水生王天山
Owner 许庆彤