Wound care product with peracid composition
A composition, wound technology, applied in the field of dressings and bandages, wound coverings, which can solve problems such as loss of activity
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Embodiment 1
[0098] Example 1. Dissolving film formulations
[0099] In one embodiment, the membrane dissolves upon contact with a fluid, such as water from a matrix such as a hydrogel, or fluid released from the treatment site.
[0100] The film may be composed of a soluble hydrocolloid such as pullulan. The film may comprise one or more layers, any of which may further comprise emulsifiers, solubilizers, wetting agents, flavoring agents, plasticizers, active agents, water-soluble inert fillers, preservatives, buffers, Colorants, stabilizers or combinations thereof.
[0101] The formulation for the dissolvable layer may contain: (1) a rapidly dissolving film component such as pullulan, typically 10% to 95% by weight, (2) a plasticizer for flexibility, such as lambda carrageen Gum, generally 0.05% to 35% by weight, (3) dissolution regulator (such as hydroxymethylcellulose), generally 0.1% to 10%, and (4) surfactant, for dispersion, such as 0.001% to 0.1% polysorbate A. The initial pr...
Embodiment 2
[0105] Example 2. Hydrogel-Dissolvable Film Multilayer Compositions
[0106] The PVA hydrogel layer was prepared by mixing 10% PVA (w / w) and heating at 95 °C, allowing it to cool, and then pouring on a glass plate with a Teflon layer mat (approximately 2.5 mm) to form 13×13×0.25cm in size. Another glass plate was placed on top and the two plates were clipped together with medium paper binder clips. The entire assembly was then wrapped in non-adhesive aluminum foil and subjected to one freeze-thaw cycle. In one embodiment, repeated cycles of freezing and thawing the polymer solution result in the repulsion of the solids close to each other forcing the polymer units (possibly by van der Waals attraction and possibly by ionic bonding), resulting in the formation of a solid hydrogel. Preferably, the polymer is frozen below -20°C for 10 to 20 hours, with cycles of freeze-thaw resulting in tighter binding, which in turn allows the pore size to be altered to control the rate at w...
Embodiment 3
[0107] Example 3. Preparation of Rapidly Dissolving Films
[0108] The formulation for the dissolvable layer may contain: (1) a rapidly dissolving film component such as pullulan, typically 10% to 95% by weight, (2) a plasticizer for flexibility such as beta-carrageen Gum, generally 0.05% to 35% by weight, (3) dissolution regulator (such as hydroxymethyl cellulose), generally 0.1% to 10%, and (4) surfactant, for dispersion, such as 0.001 % to 0.1% Polysorbate A. The initial preparation was mixed with the desired concentration (100 ppm to 10000 ppm) of the peracid composition in deionized water and cast. Depending on the casting method and degree of drying, the final residual moisture content is generally 1% to 4%.
[0109] An occlusive film, an aluminized polyester film with an adhesive backing, is usually applied on the substrate.
[0110] The two components can be assembled just before or at the time of application to the wound site, whereby the dry film is applied on t...
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Abstract
Description
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