Traditional Chinese medicine blood-stasis dispersing composition for treating woman chronic pelvic inflammation and preparation method thereof

A technology for chronic pelvic inflammatory disease and composition, which is applied in the field of medical preparations, can solve the problems of stubbornness, protracted disease course, poor physical fitness of patients, etc., and achieves the effects of rapid drug release, symptom relief, and convenient administration.

Inactive Publication Date: 2015-09-16
THE AFFILIATED HOSPITAL OF QINGDAO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The technical problem to be solved by the present invention is that chronic pelvic inflammatory disease and adnexitis are common diseases in gynecology, and most of them are caused by acute pelvic inflammatory disease that has not been properly and completely treated or the patient's constitution is poor and the course of the disease is protracted.

Method used

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  • Traditional Chinese medicine blood-stasis dispersing composition for treating woman chronic pelvic inflammation and preparation method thereof
  • Traditional Chinese medicine blood-stasis dispersing composition for treating woman chronic pelvic inflammation and preparation method thereof
  • Traditional Chinese medicine blood-stasis dispersing composition for treating woman chronic pelvic inflammation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0064] The preparation steps of the honey pill for oral administration of the present invention are as follows: take 1500g of Salvia miltiorrhiza, 1500g of Andrographis paniculata, 1500g of Caulis Spatholobus, 1500g of Motherwort, 1500g of peach kernel, 1500g of Patrinia, 1500g of Lonicerae vine, 1500g of Daqingye, 1500g of Radix Spatholobus, and red peony 1500g, Lingxiaohua 1500g, Toosendan 1500g, Dandelion 1500g, Scutellaria baicalensis 1500g, Corydalis 1500g, add all the raw materials to 5-10 times the amount of ethanol and soak for 1-2 hours, heat and extract twice, 1-2 hours each time, Remove the supernatant, combine the extracts, filter through 100-120 mesh, and then ultra-filter through an ultra-filtration column with a cut-off molecular weight of 5000-10000. The ultra-filtrate is concentrated under reduced pressure and the relative density is 1.38 at 80 ° C. Heat and concentrate To the extract form, let it stand for later use, and become component 1. Put the dregs extr...

Embodiment 3

[0089] Embodiment 3: Vaginal mucosa irritation test result

[0090] 1. Test method:

[0091] After 3 days of experimental animal quarantine, select 18 above-mentioned healthy rabbits for use, and be randomly divided into three groups, each group of 6, respectively: blank control, excipient control, suppository group of the present invention (5 times concentration by application solution). Sterilized tampons of appropriate size soaked in sterilized physiological saline and the test substance were placed in the vagina of the animals in the vehicle control group and the test substance group, and were in contact with the vaginal mucosa for 6 hours, and the animals were sacrificed 24 hours later. The local vaginal tissue was taken out and the lesion was observed.

[0092] 2. Test results: vaginal mucosa irritation test results

[0093]

Embodiment 4

[0094] Embodiment 4: skin allergy test result

[0095] Use the suppository of the present invention to carry out induction and excitation contact tests, observe the test mice after 24 hours and 48 hours, and there is no phenomenon such as erythema and edema in the skin, and there is no difference with the negative control group. The results show that the suppository has close to zero skin reaction intensity, that is, no skin allergy.

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Abstract

The invention discloses a traditional Chinese medicine blood-stasis dispersing composition for treating woman chronic pelvic inflammation. The traditional Chinese medicine blood-stasis dispersing composition comprises an oral preparation and an externally applied preparation, wherein the oral preparation comprises the following components in parts by weight: 10-20 parts of the root of red-rooted salvia, 10-20 parts of herba andrographitis, 10-20 parts of caulis spatholobi, 10-20 parts of leonurus, 10-20 parts of peach kernel, 10-20 parts of patrinia, 10-20 parts of honeysuckle stem, 10-20 parts of folium isatidis, 10-20 parts of sargentgloryvine stem, 10-20 parts of the root of common peony, 10-20 parts of campsis grandiflora, 10-20 parts of szechwan chinaberry fruits, 10-20 parts of dandelion, 10-20 parts of scutellaria baicalensis, and 10-20 parts of corydalis tuber; and the externally applied preparation comprises the following components in parts by weight: 10-20 parts of fructus forsythiae, 10-20 parts of fructus kochiae, 10-20 parts of indigo naturalis, 10-20 parts of fructus cnidii, 10-20 parts of szechwan chinaberry fruits, 10-20 parts of lithospermum, 10-20 parts of oldenlandia diffusa, 10-20 parts of the root bark of the peony tree, 10-20 parts of rhizoma cyperi, 10-20 parts of radix angelicae, 10-20 parts of radix sophorae flavescentis, 10-20 parts of rhizoma smilacis glabrae, 10-20 parts of golden cypress, and 10-20 parts of radix zanthoxyli. The traditional Chinese medicine blood-stasis dispersing composition disclosed by the invention has the effects of promoting blood circulation to remove blood stasis, eliminating dampness and heat and being direct to source lesion; and the traditional Chinese medicine blood-stasis dispersing composition has the obvious effect on treating chronic pelvic inflammation.

Description

technical field [0001] The invention relates to a medical preparation containing raw materials derived from plants, animals or minerals, in particular to a traditional Chinese medicine blood stasis removing composition for treating women's chronic pelvic inflammatory disease and a preparation method thereof. Background technique [0002] There is no disease name for pelvic inflammatory disease in Chinese medicine, so it belongs to the category of "dysmenorrhea" and "leukorrhea". The disease has a long course and is lingering and difficult to heal. Evil accumulates in the uterus, rushes to the office, QI and blood are not running smoothly, and its pathogenesis is always suffocated at the root. Leukorrhea is called leukorrhea when the amount of leukorrhea increases significantly, the color, quality, and smell are abnormal, or it is accompanied by systemic or local symptoms. The disease is caused by damp evil affecting Chong and Ren, leading to loss of contraction of the pulse...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/90A61K36/896A61K36/736A61K36/855A61P15/00A61P15/02
Inventor 李恩泽马霖刘月芬李娅娟宋楠楠
Owner THE AFFILIATED HOSPITAL OF QINGDAO UNIV
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