Traditional Chinese medicine blood-stasis dispersing composition for treating woman chronic pelvic inflammation and preparation method thereof
A technology for chronic pelvic inflammatory disease and composition, which is applied in the field of medical preparations, can solve the problems of stubbornness, protracted disease course, poor physical fitness of patients, etc., and achieves the effects of rapid drug release, symptom relief, and convenient administration.
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[0064] The preparation steps of the honey pill for oral administration of the present invention are as follows: take 1500g of Salvia miltiorrhiza, 1500g of Andrographis paniculata, 1500g of Caulis Spatholobus, 1500g of Motherwort, 1500g of peach kernel, 1500g of Patrinia, 1500g of Lonicerae vine, 1500g of Daqingye, 1500g of Radix Spatholobus, and red peony 1500g, Lingxiaohua 1500g, Toosendan 1500g, Dandelion 1500g, Scutellaria baicalensis 1500g, Corydalis 1500g, add all the raw materials to 5-10 times the amount of ethanol and soak for 1-2 hours, heat and extract twice, 1-2 hours each time, Remove the supernatant, combine the extracts, filter through 100-120 mesh, and then ultra-filter through an ultra-filtration column with a cut-off molecular weight of 5000-10000. The ultra-filtrate is concentrated under reduced pressure and the relative density is 1.38 at 80 ° C. Heat and concentrate To the extract form, let it stand for later use, and become component 1. Put the dregs extr...
Embodiment 3
[0089] Embodiment 3: Vaginal mucosa irritation test result
[0090] 1. Test method:
[0091] After 3 days of experimental animal quarantine, select 18 above-mentioned healthy rabbits for use, and be randomly divided into three groups, each group of 6, respectively: blank control, excipient control, suppository group of the present invention (5 times concentration by application solution). Sterilized tampons of appropriate size soaked in sterilized physiological saline and the test substance were placed in the vagina of the animals in the vehicle control group and the test substance group, and were in contact with the vaginal mucosa for 6 hours, and the animals were sacrificed 24 hours later. The local vaginal tissue was taken out and the lesion was observed.
[0092] 2. Test results: vaginal mucosa irritation test results
[0093]
Embodiment 4
[0094] Embodiment 4: skin allergy test result
[0095] Use the suppository of the present invention to carry out induction and excitation contact tests, observe the test mice after 24 hours and 48 hours, and there is no phenomenon such as erythema and edema in the skin, and there is no difference with the negative control group. The results show that the suppository has close to zero skin reaction intensity, that is, no skin allergy.
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