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Application of poly(1,3-propylene glycol-sebacic acid ester) in preparing retina nerve cell carrier

A technology of retinal progenitor cells and nerve cells, which is used in the application field of preparing retinal nerve cell carriers, can solve problems such as lack of research on properties, and achieve the effects of good application potential, low inflammatory and apoptotic factors, and proliferation promotion.

Active Publication Date: 2015-09-23
DONGHUA UNIV
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  • Abstract
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AI Technical Summary

Problems solved by technology

There is a lack of more comprehensive research on the properties of PPS, and no reports on its specific applications

Method used

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  • Application of poly(1,3-propylene glycol-sebacic acid ester) in preparing retina nerve cell carrier
  • Application of poly(1,3-propylene glycol-sebacic acid ester) in preparing retina nerve cell carrier
  • Application of poly(1,3-propylene glycol-sebacic acid ester) in preparing retina nerve cell carrier

Examples

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Embodiment 1

[0024] (1) Preparation of PPS

[0025] Recrystallized sebacic acid (J&K, 98%) and equimolar amounts of 1,3-propanediol (Energy Chemical, 99%) were pre-polymerized at 135 ° C for 24 hours in a nitrogen environment, and then the reaction temperature was kept constant. The reaction system was evacuated (3 bar) for 57 hours, the reaction product was precipitated and purified in ether, and the purified product was dried under vacuum for 24 hours to obtain white solid PPS.

[0026] (2) Isolation and culture of RPCs

[0027] The animals used in this experiment were in accordance with the Animal Use Standards of the Society of Vision and Ophthalmology, and strictly followed the procedures approved by the Animal Feeding and Use Committee of the Schepens Eye Institute. Retinal progenitor cells were obtained from postnatal day 1 transgenic C57BL / 6 mice that were positive for green fluorescent protein (GFP+), and retinals were minced and isolated by several cycles of digestion with 0.1% ...

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Abstract

The invention relates to application of poly(1,3-propylene glycol-sebacic acid ester) in preparing a retina nerve cell carrier. Retina progenitor cell RPCs performs proliferation, differentiation and translocation on the retina nerve cell carrier; the component of the retina nerve cell carrier comprises the poly(1,3-propylene glycol-sebacic acid ester) PPS. The PPS has good biocompatibility, inflammation and apoptosis factors of cells are low, remarkable promotion effect is achieved on proliferation of the retina nerve cells, and the PPS has good application potential in the retina nerve cell transplantation and retina nerve cell repairing.

Description

technical field [0001] The invention belongs to the field of retina repair, and particularly relates to the application of poly(1,3-propanediol-sebacate) in the preparation of retinal nerve cell carriers. Background technique [0002] Age-related macular degeneration (AMD) and retinitis pigmentosa (RP) are two major contributors to the degeneration of optic neurons leading to visual impairment. Newly developed treatments can rebuild the damaged retinal neurons. As a result, a variety of therapeutic methods have been developed, such as gene therapy, growth factor therapy and small molecule drug therapy. However, these treatment methods can only delay the progression of the disease, but cannot fundamentally treat the disease. In recent years, the treatment method of culturing retinal neurons in vitro and then transplanting them into the body to replace diseased tissues has received more and more attention. But finding a suitable cell growth matrix as a delivery vehicle for ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N5/071C08G63/16C08G63/78
Inventor 游正伟王少飞陈硕谷平倪妮
Owner DONGHUA UNIV
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