Preparation method of calamine lotion

A technology for calamine and lubricant, which is applied in the field of preparation of calamine lotion, can solve the problems of difficult agglomeration, difficulty in obtaining powder, and a gritty feeling after long-term storage, saves follow-up work, and improves the stability of suspension. The effect of improving the property and powder solubility

Active Publication Date: 2015-09-30
HUNAN ER KANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the calamine lotion prepared by this method has a slow layered sedimentation speed and is not easy to agglomerate after long-term storage, it is difficult to obtain a fine powder with a nylon plastic mesh bag, which will produce a gritty feeling when applied, and after drying easy to fall off

Method used

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  • Preparation method of calamine lotion
  • Preparation method of calamine lotion

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] 150kg of calamine and 500kg of zinc oxide are prepared into superfine powder with a diameter of 3μm by a jet mill. The two are ground and mixed by dry method, and they are mixed with isopropanol 10L and glycerol 30L to wash repeatedly, then Add the mixture of colloidal microcrystalline cellulose, potassium citrate and sodium tartrate (mass ratio 1:1), glycerin, magnesium stearate=1:0.2:0.9:0.01 to mix the suspension stabilizer, and the concentration is 30%- The 50% suspension is finally filled into a finished product.

Embodiment 2

[0030] 150kg of calamine and 500kg of zinc oxide are prepared into ultrafine powder with a diameter of 5μm by a jet mill. The two are ground and mixed by dry method, and they are mixed with isopropanol 10L and glycerol 50L to wash repeatedly, then Add colloidal microcrystalline cellulose, potassium dihydrogen phosphate, glycerin, magnesium stearate=1:0.3:1.0:0.03 to mix the suspension stabilizer, prepare a suspension with a concentration of 30%-50%, and finally fill the finished product.

Embodiment 3

[0032] 150kg of calamine and 500kg of zinc oxide are prepared into ultrafine powder with a diameter of 8μm by a jet mill. The two are ground and mixed by dry method. They are mixed with isopropanol 10L and glycerol 80L to wash repeatedly, then Add colloidal microcrystalline cellulose, sodium tartrate, glycerin, magnesium stearate=1:0.3:1.0:0.05 to mix the suspension stabilizer, prepare a suspension with a concentration of 30%-50%, and finally fill the finished product.

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Abstract

The invention provides a preparation method of a calamine lotion. The method specifically includes the steps of: mixing and grinding, cleaning, liquid preparation mixing, and filling, thus obtaining a finished product. The product obtained by the method provided by the invention has suspension liquid with good stability and lasting suspension property, the microorganisms are effectively controlled, and no gravel feel is generated during application of the lotion.

Description

technical field [0001] The invention relates to a preparation method of calamine lotion, in particular to a method of using superfine powder of calamine and zinc oxide through dry grinding, mixing liquid and stirring to make calamine suspension, which belongs to pharmaceutical manufacturing field. Background technique [0002] The main components of calamine lotion are calamine and zinc oxide, which is a pink suspension with a long clinical application time for skin external application. It has the effect of astringent and protecting the skin, and is suitable for acute itching skin diseases such as urticaria and prickly heat. [0003] The preparation of calamine is mainly external lotion, which is to grind calamine and zinc oxide into fine powder, add appropriate amount of water and glycerin to make a solid suspension, shake well before each use, and apply an appropriate amount on the affected area . The traditional preparation method of calamine lotion is to grind 150g o...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/10A61K33/30A61K47/38A61K47/10A61K47/12A61P17/04
Inventor 帅放文王向峰章家伟
Owner HUNAN ER KANG PHARMA
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