A kind of pharmaceutical composition containing solifenacin succinate

A technology of solifenacin succinate and composition, which is applied in the direction of drug combination, active ingredients of heterocyclic compounds, medical preparations of non-active ingredients, etc., and can solve the problems of poor dissolution rate of solifenacin succinate tablets, etc.

Active Publication Date: 2017-12-29
SICHUAN GOWELL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] Using the prior art prescription, the solifenacin succinate tablet prepared by the powder direct compression method always has the problem of poor dissolution rate

Method used

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  • A kind of pharmaceutical composition containing solifenacin succinate
  • A kind of pharmaceutical composition containing solifenacin succinate
  • A kind of pharmaceutical composition containing solifenacin succinate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0126] composition

[0127] Weigh the required raw and auxiliary materials according to the prescription amount, first mix solifenacin succinate with sodium carboxymethyl starch and high-substituted hydroxypropyl cellulose, then add 10% direct compression lactose, and add 20% of Directly compress lactose, mix evenly, then add 30% direct-compressed lactose for mixing, add the remaining direct-compressed lactose, mix and pass through a 50-mesh sieve, mix well, finally add micropowder silica gel and mix well, use powder direct-compression tablet press Tablets, coated, ready to serve.

Embodiment 2

[0129] composition

[0130] Weigh the required raw and auxiliary materials according to the prescription amount and pass through a 50-mesh sieve respectively. First mix solifenacin succinate with sodium carboxymethyl starch and gum arabic, then add 20% direct-pressed lactose, mix well, and then add Mix 30% direct-compression lactose, add the remaining direct-compression lactose, mix and sieve through a 50-mesh sieve, mix evenly, finally add talcum powder and mix evenly, use a rotary tablet machine to compress, coat, and get ready.

Embodiment 3

[0132] composition

[0133] Weigh the required raw and auxiliary materials according to the prescription amount, first mix solifenacin succinate with sodium carboxymethyl starch, croscarmellose sodium, hypromellose and mannitol, and then add 20% Directly compress lactose, mix evenly, then add 30% direct-press lactose for mixing, add the remaining lactose, mix and pass through a 50 mesh sieve, mix evenly, finally add calcium stearate and mix evenly, use a rotary tablet machine to compress, pack Clothes, get it.

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Abstract

The invention relates to a pharmaceutical composition containing solifenacin succinate. The pharmaceutical composition is characterized by simultaneously containing direct compression lactose, sodium carboxymethyl starch, a binder and a lubricating agent. The invention also discloses a preparation method, namely a direct powder compression method of the pharmaceutical composition. The pharmaceutical composition and the preparation method thereof are not influenced by water in the preparation process, the pharmaceutical composition is low in impurity content and better in drug dissolubility, and the preparation method is more suitable for industrial production.

Description

technical field [0001] The invention relates to pharmaceutical preparations, in particular to a pharmaceutical composition containing solifenacin succinate and a preparation method thereof. Background technique [0002] Solifenacin Succinate, 1-azabicyclo[2.2.2]octane-8-yl-(1S)-1-phenyl-3,4-dihydro-1H-isoquinoline-2 - formate succinate) is a new generation of M 3 Receptor antagonist, acts on the M receptor on the detrusor muscle, reduces the overactivity of the detrusor muscle, thereby relieving symptoms such as urgency, frequency and urge urinary incontinence caused by overactive bladder muscle, compared with similar drugs , which has the highest selectivity for the bladder, so it has stronger curative effect, fewer side effects, and better tolerance and compliance of patients. The first-line treatment drugs recommended in the treatment guidelines. [0003] The original manufacturer of solifenacin succinate is Astellas Corporation of Japan. The product was first launched...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K9/28A61K31/49A61K47/36A61K47/26A61P13/10
Inventor 蒋代财王理黄毅郭礼新郭晖
Owner SICHUAN GOWELL PHARMA
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