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A kind of size-determined Wudan Fupian granule and its preparation method

A sizing and granule technology, applied in the field of Wudanfu Tablet granules and their preparation, can solve the problems of reduced clinical efficacy stability, obvious differences in the proportion of pulp, and low content of pulp, etc., and achieves enhancement, stability and controllability, and uniform specifications. , the effect of improving retention

Active Publication Date: 2018-06-26
THE FIFTH MEDICAL CENT OF CHINESE PLA GENERAL HOSPITAL +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The alkaloids in aconite are mainly distributed in the epidermis and the skin outside the cambium, and the pith content is low. The ratio of the pith in large sheets and small sheets is significantly different, resulting in a very obvious difference in content, which directly reduces the clinical curative effect. stability

Method used

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  • A kind of size-determined Wudan Fupian granule and its preparation method
  • A kind of size-determined Wudan Fupian granule and its preparation method
  • A kind of size-determined Wudan Fupian granule and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] The preparation (once drying) of embodiment 1 Wugaofu Tablets:

[0025] Take fresh aconite or refrigerated aconite, wash and remove the mud; use a CHD100 dicing machine to cut the aconite into 5mm×5mm×5mm particles, spread it on a large square plate in a single layer, and place it in a blast at 100°C In a drying box, dry with hot air for 10 hours to obtain the finished product.

Embodiment 2

[0026] The preparation of embodiment 2 gallbladder-free tablets (twice drying):

[0027] Take fresh aconite or refrigerated aconite, wash and remove the mud; use a CHD100 dicing machine to cut the aconite into 5mm×6mm×7mm particles, spread it on a large square plate in a single layer, and place it in a blast at 100°C In a drying oven, dry with hot air for 3 hours until the moisture content is below 10% to obtain an intermediate product, which is stored in a cool and ventilated place sealed. During subsequent processing, the intermediate product is taken out, and dried in a blast drying oven at 100°C for 7 hours with hot air to fully detoxify it to obtain a finished product.

Embodiment 3

[0028] Example 3 Comparison of the chemical composition of the gallbladder-free tablets prepared by the present invention and the commercially available tablets

[0029] The contents of 6 alkaloid components in 9 commercially available Fupian and Wudan Fupian granules prepared in Example 1 of the present invention were determined by HPLC, and the results are shown in Table 1.

[0030] As can be seen from Table 1, in terms of the sum of the contents of the monoester-type alkaloids of the medicinally active ingredients, the Wudanfu Tablets granules of the present invention>Steamed Fuzi>Heishun Tablets>Shengfu Tablets>Paofuzi>Baifuzi slices>fried slices>planed slices>Pao Tianxiong. The content of the medicinal active ingredient of the Wudanfupian granule of the present invention is much higher than the 0.01% standard stipulated in the Pharmacopoeia and is also much higher than other decoction pieces, which shows that the preparation method of the Wudanfupian granule of the presen...

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Abstract

The invention provides a method for preparing no-bile accessory piece particles with fixed dimension, which comprises the steps: washing of fresh mud aconite, granulating and drying. The no-bile accessory piece particles do not have bile or sulphur, are high in efficacy active ingredients, low in toxic component content, uniform in specification, convenient to regulate, simple and practical in production process, high in fresh processing capacity, low in cost and convenient for industrialized mass production, and has excellent application prospect.

Description

technical field [0001] The invention relates to a sized Wudan Fupian granule and a preparation method thereof. Background technique [0002] Aconite is the root of Aconitum carmichaeli Debx, a plant of the genus Aconitum in the family Ranunculaceae. It is known as "the first medicine for recovering yang and rescuing adversity". [0003] Modern research suggests that diester-type alkaloids such as aconitine, hypoaconitine, and neoaconitine contained in the processed products and preparations of aconitine have a clear cardiotonic effect on acute and chronic heart failure; Ester-type alkaloid content is too high, and can produce strong cardiotoxicity, and the symptoms are manifested as ventricular premature beats, ventricular tachycardia, ventricular fibrillation and even death. Therefore, it is known as "the most difficult and most useful medicine". [0004] In view of the fact that aconite is a classic toxic drug with severe effects, a processing method based on processing...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/714A61K9/16A61P9/04
Inventor 王伽伯肖小河张定堃赵艳玲韩雪李刚严桂林
Owner THE FIFTH MEDICAL CENT OF CHINESE PLA GENERAL HOSPITAL