Use of a resveratrol derivative for skin whitening

A technology for resveratrol and skin whitening, applied in skin diseases, preparations for skin care, drug combinations, etc., can solve the problems of unguaranteed chemical stability, no reliable and complete countermeasures, etc., and achieve excellent chemical stability. Effect

Inactive Publication Date: 2015-10-21
国立庆北大学校产学协力团
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the chemical stability of these compounds is not guaranteed, and it is difficult to formulate them as cosmetic or pharmaceutical compositions that can be stored for more than several months.
In order to solve this problem, efforts such as the development of new dosage forms have been tried, but no reliable and complete countermeasures have been achieved so far.

Method used

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  • Use of a resveratrol derivative for skin whitening
  • Use of a resveratrol derivative for skin whitening
  • Use of a resveratrol derivative for skin whitening

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0099] Embodiment 1: the preparation of triacetyl resveratrol (triacetyl resveratrol; III)

[0100]

[0101] 20 g of resveratrol (resveratrol; I) was dissolved in a mixture of 100 g of pyridine (pyridine) and 200 g of anhydrous acetic acid (acetic acid), and stirred at room temperature for 24 hours. 700 g of water was gradually added and mixed to the above mixture, and the reactant was precipitated. It was filtered, the above-mentioned precipitate was recovered, washed with water, then heated and dissolved in 2000 g of ethanol, and placed at room temperature to induce crystallization. It was filtered again, and the crystals were recovered and dried to obtain 22 g of triacetylresveratrol (triacetylresveratrol; III).

Embodiment 2

[0102] Embodiment 2: Preparation of tetraacetyl oxyreveratrol (tetraacetyl oxyreveratrol; IV)

[0103]

[0104]After dissolving 20 g of oxidized resveratrol (oxyresveratrol; II) in a mixture of 200 g of pyridine (pyridine) and 50 g of anhydrous acetic acid (acetic acid), it was stirred at 50° C. for 3 hours. 750 g of water was gradually added and mixed to the above mixture, and the reactant was precipitated. It was filtered, the above-mentioned precipitate was recovered, washed with water, then heated and dissolved in 200 g of ethanol, 100 g of water was slowly added, and placed at room temperature to induce crystallization. This was filtered again, and the crystals were recovered and dried to obtain 24 g of tetraacetyl oxyresveratrol (IV).

[0105] Analysis Example 1: Analysis of the prepared triacetyl resveratrol and tetraacetyl oxidized resveratrol

[0106] In order to confirm the triacetyl resveratrol and tetraacetyl oxidized resveratrol prepared in the above Examples...

Embodiment 3

[0117] Example 3: Whitening efficacy evaluation of triacetyl resveratrol and tetraacetyl oxidized resveratrol in test tubes at the cell level

[0118] In order to know the skin whitening effect of triacetyl resveratrol and tetraacetyl oxidized resveratrol prepared in Examples 1 and 2 above, the influence on tyrosinase inhibitory activity and cell viability and Cellular melanin (melanin) production inhibitory effect.

[0119] In order to confirm the effect of the above compounds at the cellular level, mouse black strain B16F10 cells were purchased from the American Type Culture Collection (ATCC) and used. Cells were incubated with DMEM medium containing 10% fetal bovine serum (FBS), 100 U / ml penicillin and 0.1 mg / ml streptomycin at 37°C in 5% CO 2 cultured in an incubator.

[0120] 3-1: Inhibition effect of tyrosinase activity in the test tube

[0121] Collect the cultured cells, add cell lysate (10mM Tris-Cl, pH 7.4, 120mM NaCl, 25mM KCl, 2mM EGTA, 1mM EDTA, 0.5% Triton X...

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PUM

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Abstract

The present invention relates to a use of a resveratrol derivative for skin whitening, and more specifically, to: a cosmetic composition containing an acetylated derivative of resveratrol or a hydroxy derivative thereof, or a cosmetically acceptable salt thereof as an active ingredient; a cosmetic product containing the cosmetic composition; a skin whitening pharmaceutical composition containing an acetylated derivative of resveratrol or a hydroxy derivative thereof, or a pharmaceutically acceptable salt thereof as an active ingredient; a skin preparation for external use, containing the skin whitening pharmaceutical composition; a skin whitening method in which an acetylated derivative of resveratrol or a hydroxy derivative thereof, or a pharmaceutically acceptable salt thereof is administered to an individual; and a novel resveratrol derivative compound having a skin whitening effect.

Description

technical field [0001] The present invention relates to the use of resveratrol derivatives for skin whitening, and more specifically, to cosmetic cosmetics containing resveratrol or its hydroxy derivatives, acetylated derivatives, or its cosmetically acceptable use as active ingredients. Cosmetic composition; Cosmetics containing the above-mentioned cosmetic composition; Pharmaceutical composition for skin whitening containing resveratrol or its hydroxy derivative, acetylated derivative or its pharmaceutically acceptable salt as an active ingredient; A skin external preparation comprising the above-mentioned pharmaceutical composition for skin whitening; a skin whitening method in which resveratrol or its hydroxy derivative, acetylated derivative, or its pharmaceutically acceptable salt is administered to an individual; Novel resveratrol derivative compound with whitening effect. Background technique [0002] Melanin is a pigment that can be found everywhere in nature and e...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/34A61K8/30A61Q19/02A61Q19/00
CPCA61Q19/02A61K8/375A61P17/00A61K8/30A61K8/34A61Q19/00
Inventor 夫勇出
Owner 国立庆北大学校产学协力团
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