Method for preparing porous hydrogel through micropore self foaming

Abstract

The invention relates to a method for preparing porous hydrogel through micropore self foaming. The method comprises the following steps: A, at a room temperature, dissolving 4-7 parts by weight of polyglutamic acid and 2-5 parts by weight of lysine into 45-55 parts by weight of distilled water, and stirring evenly at the speed of 100-200 r / min, so as to obtain a uniform phase solution of the polyglutamic acid and the lysine; B, adding 3-7 parts by weight of 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide and 2-4 parts by weight of N- hydroxysuccinimide into the uniform phase solution obtained in the step A, and evenly stirring at the speed of 500-800 r / min, so as to form a to-be-foamed uniform phase solution; C, pouring the to-be-foamed uniform phase solution obtained in the step B into a die, leaving the to-be-foamed uniform phase solution to stand, namely, starting out self foaming to form hydrogel; D, soaking the hydrogel obtained in the step C into ethyl alcohol for cleaning, namely, completing preparation. The method is simple and convenient in operation process, short in production period and mild in reaction conditions, and the prepared porous hydrogel is excellent in biocompatibility.

Description

technical field [0001] The invention relates to a method for preparing a hydrogel material, in particular to a method for preparing a porous hydrogel material by microporous self-foaming. Background technique [0002] Hydrogel is a kind of polymer which is hydrophilic but insoluble in water. They can rapidly expand to equilibrium volume in water and maintain their shape and three-dimensional space network structure, and dehydrate and deswell under certain conditions. They are a kind of functional polymer materials that integrate water absorption, water retention and slow release and develop rapidly. , are widely used in industry, agriculture, engineering medicine and bioengineering and other fields. [0003] Porous hydrogel refers to the introduction of a porous structure in the hydrogel, which can quickly absorb water into the hydrogel through capillary action; and the porous structure greatly increases the specific surface area inside the gel, making the hydrophilic group...

AI Technical Summary

Problems solved by technology

The disadvantages of the porogenic method are: the time required for dissolving, washing, and soaking to remove the porogen is longer, which prolongs the time for material preparation; a small amount of porogen is easy to remain in the product; the porosity of the pore structure is poor; The hydrogel network structure is easily destroyed by acid washing

This method needs to add different organic solvents as the solvent phase, which has a certain inhibitory effect on the polymerization of the polymer, and at the same time prolongs the material preparation cycle in the process of removing the solvent, and the volatilization of some organic solvents will cause environmental pollution. certain pollution

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