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Hyaluronic acid and silica gel composition for scar prevention and early repair and preparation method of hyaluronic acid and silica gel composition

A technology of hyaluronic acid and composition, applied in the field of external silicone gel composition, can solve the problems of poor water absorption of silicone gel, discounted effect, skin redness, etc., and achieve the effects of reducing tension, reducing the formation of free radicals, and making skin flexible

Active Publication Date: 2015-11-04
郑州和济生物科技股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the poor water absorption of silicone gel, skin redness, itching, tightness, and discomfort will appear during use. Users often fail to persist and the effect is greatly reduced.

Method used

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  • Hyaluronic acid and silica gel composition for scar prevention and early repair and preparation method of hyaluronic acid and silica gel composition

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] The method for preparing the silicone gel composition for preventing scar formation and early repair comprises the following steps:

[0030] Step 1: Add 5g of hyaluronic acid into 200ml of purified water and stir evenly to make a hyaluronic acid solution;

[0031] In the second step, add 25g of onion extract to 200ml of purified water and stir evenly to make an onion extract solution;

[0032] The third step, first add 5g of carbomer to 100g of glycerol and stir. After dissolving, add 200ml of purified water and stir evenly, let it stand for 2-4 hours, then add 5g of triethanolamine to adjust the pH to 6.5- 7.0, made into carbomer solution;

[0033] In the fourth step, add hyaluronic acid solution and onion extract solution to the carbomer solution prepared in the third step and stir, then add 150g of polydimethylsiloxane and 150g of dimethylsiloxane cross-linked polymer Stir evenly and pass through a colloid mill to obtain a silicone gel composition for preventing sc...

Embodiment 2

[0035] The method for preparing the silicone gel composition for preventing scar formation and early repair comprises the following steps:

[0036] Step 1: Add 0.5g of hyaluronic acid into 200ml of purified water and stir evenly to make a hyaluronic acid solution;

[0037] In the second step, add 10 g of onion extract to 200 ml of purified water and stir evenly to make an onion extract solution;

[0038]The third step, first add 4g of carbomer to 100g of glycerol and stir. After dissolving, add 200ml of purified water and stir evenly, let it stand for 2-4 hours, then add 5g of triethanolamine to adjust the pH to 6.5- 7.0, made into carbomer solution;

[0039] In the fourth step, add hyaluronic acid solution and onion extract solution to the carbomer solution prepared in the third step and stir, then add 100g of polydimethylsiloxane and 100g of dimethylsiloxane cross-linked polymer Stir evenly and pass through a colloid mill to obtain a silicone gel composition for preventing...

Embodiment 3

[0041] The method for preparing the silicone gel composition for preventing scar formation and early repair comprises the following steps:

[0042] Step 1: Add 10g of hyaluronic acid into 200ml of purified water and stir evenly to make a hyaluronic acid solution;

[0043] In the second step, add 50 g of onion extract to 200 ml of purified water and stir evenly to make an onion extract solution;

[0044] The third step, first add 6g of carbomer to 120g of glycerol and stir. After dissolving, add 200ml of purified water and stir evenly. Let stand for 2-4 hours, then add 8g of triethanolamine to adjust the pH to 6.5- 7.0, made into carbomer solution;

[0045] In the fourth step, add hyaluronic acid solution and onion extract solution to the carbomer solution prepared in the third step and stir, then add 200g of polydimethylsiloxane and 200g of dimethylsiloxane cross-linked polymer Stir evenly and pass through a colloid mill to obtain a silicone gel composition for preventing sc...

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Abstract

The invention provides a hyaluronic acid and silica gel composition for scar prevention and early repair and a preparation method of the hyaluronic acid and silica gel composition. The method includes the steps of adding purified water to hyaluronic acid to be evenly stirred to prepare a hyaluronic acid solution, adding purified water to onion extract to prepare an onion extract solution, adding carbomer and purified water to glycerol to be evenly stirred to prepare a carbomer solution, sequentially adding the hyaluronic acid solution and the onion extract solution to the carbomer solution to be stirred, adding polydimethylsiloxane and dimethyl siloxane cross-linked polymers to be evenly stirred, making the mixture pass through a colloid mill, and obtaining the hyaluronic acid and silica gel composition. By adding natural plant extract for promoting skin wound healing, natural moisturizing factors, namely, hyaluronic acid, and siloxane polymers, the good effect of preventing scars from being formed is achieved, the effect of rapidly repairing scars in the early stage is achieved, and good effects are achieved for prevention and early repair of scars caused by general operations, traumas and burns.

Description

technical field [0001] The invention relates to a silicone gel composition for external use, in particular to a hyaluronic acid silicone gel composition for preventing scar formation and early repair and a preparation method thereof. Background technique [0002] "Scar" is caused by physical, biological, and chemical factors such as caesarean section, breast augmentation surgery, mole removal surgery, trauma, burns and other factors that damage the human skin and soft tissue, resulting in serious damage to the skin and soft tissue and cannot be fully repaired by itself. Local symptoms left by tissue replacement repair that affect both appearance and function. Once the skin and soft tissue are damaged that may cause scars, preventing and blocking the formation of scars is the most active means. Scars usually start to turn red and harden after two weeks of wound healing, and then grow slowly. If we prevent scars in time during wound repair, we can prevent problems before they...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K36/8962A61P17/02A61P17/00A61K31/80A61K31/728
Inventor 崔广州
Owner 郑州和济生物科技股份有限公司
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