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Slow release/controlled release tablet for inhibiting breast cancer tumor activity and preparation method thereof

A breast cancer tumor, controlled-release tablet technology, applied in the field of medicine, can solve problems such as difficult anti-cancer drugs, and achieve the effects of significant social and economic significance, easy operation, and high anti-cancer activity.

Inactive Publication Date: 2015-11-11
李荣勤
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the process of developing metformin as an anticancer drug, it was found that metformin is difficult to be used as a single anticancer drug at physiological doses.

Method used

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  • Slow release/controlled release tablet for inhibiting breast cancer tumor activity and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Example 1 Sustained-release / controlled-release tablets for inhibiting breast cancer tumor activity are mainly prepared from the following raw materials: metformin hydrochloride 40g, gdc094120g, hydroxypropyl methylcellulose 12g, ethylcellulose 5.6g, magnesium stearate 2.8 g.

[0027] (1) Grind metformin hydrochloride, gdc0941 ​​and hydroxypropyl methylcellulose through an 80-mesh sieve respectively, put the pharmaceutical powder in a blender, pass through a 60-mesh sieve three times, and mix evenly;

[0028] (2) Dissolve ethyl cellulose in absolute ethanol to make a viscous solution with a content of 35%, add it to the mixed medicinal powder prepared in step (1) to make a soft material, granulate it with a 18-mesh nylon sieve, and Blast drying at 40-50°C, granulation with a 16-mesh sieve;

[0029] (3) Mix the magnesium stearate with the granules prepared in step (2), and make 12mm punched tablets to obtain.

Embodiment 2

[0030] Example 2 Sustained-release / controlled-release tablets for inhibiting breast cancer tumor activity, mainly prepared from the following raw materials: metformin hydrochloride 40g, gdc0941120g, hydroxypropyl methylcellulose 12g, ethylcellulose 5.6g, magnesium stearate 2.8 g.

[0031] (1) Grind metformin hydrochloride, gdc0941 ​​and hydroxypropyl methylcellulose through a 120-mesh sieve respectively, put the pharmaceutical powder in a blender, pass through a 60-mesh sieve three times, and mix evenly;

[0032] (2) Dissolve ethyl cellulose in absolute ethanol to make a viscous solution with a content of 35%, add it to the mixed medicinal powder prepared in step (1) to make a soft material, granulate it with a 18-mesh nylon sieve, and Blast drying at 40-50°C, granulation with a 16-mesh sieve;

[0033] (3) Mix the magnesium stearate with the granules prepared in step (2), and make 12mm punched tablets to obtain.

Embodiment 3

[0034] Example 3 Sustained-release / controlled-release tablets for inhibiting breast cancer tumor activity, mainly prepared from the following raw materials: metformin hydrochloride 40g, gdc094180g, hydroxypropyl methylcellulose 12g, ethylcellulose 5.6g, magnesium stearate 2.8 g.

[0035] (1) Grind metformin hydrochloride, gdc0941 ​​and hydroxypropyl methylcellulose through a 100-mesh sieve respectively, put the pharmaceutical powder in a blender, pass through a 60-mesh sieve three times, and mix well;

[0036] (2) Dissolve ethyl cellulose in absolute ethanol to make a viscous solution with a content of 35%, add it to the mixed medicinal powder prepared in step (1) to make a soft material, granulate it with a 18-mesh nylon sieve, and Blast drying at 40-50°C, granulation with a 16-mesh sieve;

[0037] (3) Mix the magnesium stearate with the granules prepared in step (2), and make 12mm punched tablets to obtain.

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Abstract

The invention discloses a slow release / controlled release tablet for inhibiting breast cancer tumor activity and a preparation method thereof. The slow release / controlled release tablet comprises metformin hydrochloride and gdc0941 as active components and pharmaceutically acceptable accessory materials. The preparation method has simple processes, can be operated easily and can enlarge production. An external antineoplastic test proves that metformin hydrochloride and gdc0941 can produce anticancer activity synergism. Through combination of metformin hydrochloride and gdc0941, high anticancer activity is obtained. The slow release / controlled release tablet containing metformin hydrochloride and gdc0941 has stable components, produces effects for a long time and is worthy of clinical popularization.

Description

technical field [0001] The invention belongs to the technical field of medicines, in particular to a solid oral preparation with metformin hydrochloride and gdc0941 ​​as active components. Background technique [0002] The discovery of new uses of known drugs is an important direction of new drug research and development. Metformin, the drug of choice for the initial treatment of patients with type 2 diabetes, has the advantages of being cheap, patent-protected, safe and widely used. And its potential in tumor treatment has recently become a hot spot. Many observational studies have reported a reduction in cancer incidence and mortality in diabetic patients treated with metformin. In Evans' report, diabetic patients who received metformin treatment had a 4.3% lower risk of developing cancer than patients who did not receive metformin treatment (a total of 8170 observation objects in the two groups). In the ZODIAC (Zwolle Diabetes Outpatient Integrating Existing Care Progra...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/22A61K31/155A61K31/5377A61P35/00
Inventor 李荣勤
Owner 李荣勤