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Ultrafine wall-breaking grinding method for salviae miltiorrhizae

A technology of ultra-fine wall-breaking crushing and salvia miltiorrhiza, which is applied in the field of medicine, can solve the problems of long crushing time, low powder yield of tanshinone, high loss rate of salvianolic acid B, etc., and achieve the effect of short processing time and high powder yield

Active Publication Date: 2015-11-11
深圳市盛元堂生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing ultrafine crushing method of salvia miltiorrhiza has problems such as long crushing time, low powder yield and high loss rate of tanshinone ⅡA and salvianolic acid B.

Method used

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  • Ultrafine wall-breaking grinding method for salviae miltiorrhizae
  • Ultrafine wall-breaking grinding method for salviae miltiorrhizae
  • Ultrafine wall-breaking grinding method for salviae miltiorrhizae

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] 1kg of Salvia miltiorrhiza is routinely pulverized and passed through a 80-100 mesh sieve to obtain fine powder of Salvia miltiorrhiza; mix 5g of sorbitol and 5g of phenylalanine evenly to obtain a mixed powder of sorbitol-phenylalanine; mix the fine powder of salvia miltiorrhiza with sorbitol-benzene The alanine mixed powder was mixed evenly, and pulverized by WZJ12J vibrating ultrafine pulverizer for 1 hour, and the obtained powder was measured for average particle size, powder yield, retention rate of tanshinone ⅡA and salvianolic acid B, and dissolution rate of tanshinone ⅡA and salvianolic acid B , the results are shown in Table 1.

[0017] The relevant data of the salvia miltiorrhiza superfine powder of table 1 embodiment 1

[0018]

Embodiment 2

[0020] 1 kg of Salvia Miltiorrhiza is conventionally pulverized, and passed through a 80-100 mesh sieve to obtain fine powder of Salvia Miltiorrhiza; 2.5 g of sorbitol and 2.5 g of phenylalanine are uniformly mixed to obtain a mixed powder of sorbitol-phenylalanine; -Phenylalanine mixed powder is mixed evenly, and pulverized by WZJ12J vibrating ultrafine pulverizer for 1 hour, and the obtained powder is measured for average particle size, powder yield, retention rate of tanshinone ⅡA and salvianolic acid B, and tanshinone ⅡA and salvianolic acid B Dissolution rate, the results are shown in Table 2.

[0021] The relevant data of the salvia miltiorrhiza superfine powder of table 2 embodiment 2

[0022]

Embodiment 3

[0024] 1kg of Salvia miltiorrhiza is conventionally pulverized and passed through a 80-100 mesh sieve to obtain fine powder of Salvia miltiorrhiza; mix 4g of sorbitol and 4g of phenylalanine evenly to obtain a mixed powder of sorbitol-phenylalanine; mix the fine powder of salvia miltiorrhiza with sorbitol-benzene The alanine mixed powder was mixed evenly, and pulverized by WZJ12J vibrating ultrafine pulverizer for 1 hour, and the obtained powder was measured for average particle size, powder yield, retention rate of tanshinone ⅡA and salvianolic acid B, and dissolution rate of tanshinone ⅡA and salvianolic acid B , the results are shown in Table 3.

[0025] The relevant data of the superfine powder of salvia miltiorrhiza in table 3 embodiment 3

[0026]

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Abstract

The invention provides an ultrafine wall-breaking grinding method for salviae miltiorrhizae, and belongs to the field of traditional Chinese medicines. The ultrafine wall-breaking grinding method for salviae miltiorrhizae provided by the invention comprises the following steps: (1) conventionally crushing salviae miltiorrhizae, and filtering through an 80-100mesh sieve to obtain salviae miltiorrhizae powder; (2) mixing sorbitol with phenylalanine evenly, wherein the mass ratio of the sorbitol to the phenylalanine preferably is 1 to 1, and obtaining sorbitol-phenylalanine mixed powder; and (3) mixing the salviae miltiorrhizae powder with the sorbitol-phenylalanine mixed powder evenly, wherein the mass ratio of the salviae miltiorrhizae powder to the sorbitol-phenylalanine mixed powder preferably is (200-100) to 1, crushing the powder until the mean grain size is smaller than 2 microns by an ultrafine grinder, so as to obtain ultrafine salviae miltiorrhizae wall-broken powder. Compared with a conventional ultrafine wall-breaking grinding method, the ultrafine wall-breaking grinding method for salviae miltiorrhizae provided by the invention has the advantages of short processing time, high powder extraction rate, high retention rate and dissolution rate of tanshinone IIA and salvianolic acid B, and small mean grain size of powder.

Description

technical field [0001] The invention relates to a method for ultrafine wall-breaking and crushing of salvia miltiorrhiza, belonging to the technical field of medicine. Background technique [0002] Salvia miltiorrhiza is the dry root and rhizome of Salvia miltiorrhiza in the Labiatae family. It is a commonly used Chinese medicinal material. It has the effects of promoting blood circulation and removing blood stasis, stimulating menstruation, relieving pain, clearing heart and eliminating troubles, cooling blood and eliminating carbuncle. Its main active ingredients are tanshinone ⅡA and salvianolic acid B. etc., clinically often used as medicine with powder. [0003] After ultrafine grinding of Danshen, due to the increase of the specific surface area of ​​the particle size, the dissolution rate of tanshinone Ⅱ A and salvianolic acid B can be greatly increased, thereby improving the efficacy of the medicine. The existing ultrafine wall-broken pulverization method of Salvia ...

Claims

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Application Information

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IPC IPC(8): A61K36/537A61K9/14A61K47/26A61K47/18
Inventor 郑红芹
Owner 深圳市盛元堂生物科技有限公司
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