The preparation method of dihydromyricetin-calcium complex

A technology of dihydromyricetin and complexes, which is applied in the fields of calcium organic compounds, medical preparations containing active ingredients, food science, etc., can solve problems such as difficulty in complexing with dihydromyricetin, and achieve significant economic benefits, Increased productivity and high antioxidant activity

Active Publication Date: 2017-10-31
SANMING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since the calcium ion does not have a 3d orbital, its complexation with dihydromyricetin is more difficult than that of transition metals. So far, no related reports have been seen.

Method used

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  • The preparation method of dihydromyricetin-calcium complex
  • The preparation method of dihydromyricetin-calcium complex
  • The preparation method of dihydromyricetin-calcium complex

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Weigh 0.5000g of dihydromyricetin powder, add 100mL of 95% ethanol, heat to 50°C to dissolve, then add 0.1777g of anhydrous CaCl 2 , after the solid is completely dissolved, add sodium acetate to adjust the pH value to 8.0, and adjust the intelligent constant temperature heater to 60°C, heat and reflux for 1.5h; After washing 5 times, it was dried in an oven at 50 °C for 24 h to obtain a brown solid product. The yield was 82%.

[0019] Yield = product quality / theoretical yield × 100%

[0020] Product quality—the quality of DMY-calcium chelate, unit (g);

[0021] Theoretical yield—the theoretical yield of DMY complexed with calcium ions in a ratio of 1:1, unit (g).

[0022] Effects of Reaction Parameters on the Yield of DMY-Calcium Complexation

[0023] 1. Effect of reaction temperature on DMY-calcium complexation yield

[0024] Accurately weigh 0.5000g of dihydromyricetin powder in the same amount, and the reaction solution is refluxed for 1.5h under the conditio...

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Abstract

The invention belongs to the field of complex synthesis, and specifically relates to a preparation method of a dihydromyricetin-calcium complex. The preparation method comprises the following steps: weighing 0.5000 gram of dihydromyricetin powder, adding 100 mL of ethanol (95%), heating to a temperature of 40 to 50 DEG C so as to dissolving the dihydromyricetin powder; then adding 0.1777 gram of anhydrous CaCl2, after the solid is completely dissolved, adding sodium acetate to adjust the pH to 8.0, adjusting the heating temperature to 60 DEG C, carrying out reflux reactions for 1.5 hours under heating; after the reactions are finished, cooling to the room temperature, performing suction filtration, then washing the solid by ethanol (95%) and distilled water for several times, and then baking the solid in an baking oven with a temperature of 50 DEG C for 24 hours to remove the water so as to obtain the dihydromyricetin-calcium complex. By optimizing the synthesis conditions, the complex with high anti-oxidation activity and stability can be obtained. Furthermore, the yield of dihydromyricetin-calcium complex is greatly increased, and great economic benefit is generated.

Description

technical field [0001] The invention belongs to the field of complex synthesis, and in particular relates to a preparation method of a dihydromyricetin-calcium complex. Background technique [0002] The physiological activity of dihydromyricetin metal complexes is superior to that of dihydromyricetin, and may even produce new pharmacological activities. Therefore, the research on dihydromyricetin metal complexes is expected to prepare a new type of high-efficiency flavonoid metal complex drugs, which will provide a reference for the research and development of other natural medicines. In this experimental study, by using the characteristics of DMY complexed with metal ions, it is envisaged to prepare a calcium supplement with high antioxidant activity, which can simultaneously play the physiological role of two substances, dihydromyricetin and calcium, and can supplement the human body. The required calcium can also exert or maintain the original pharmacological function of...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D311/32C07F3/04A61K31/352A23L33/165
CPCA61K31/352C07D311/32C07F3/04
Inventor 黄河宁赖煊荣
Owner SANMING UNIV
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