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Method for separating and purifying ursolic acid from loquat leaves

A technology for separation and purification of loquat leaves, which is applied in the production of organic chemistry, steroids, and bulk chemicals. It can solve the problems of high impurity content in extracts, long extraction process, and low extraction efficiency, so as to save extraction time and improve The effect of strong extraction rate and penetrating ability

Active Publication Date: 2015-12-09
杭州悦如森生物科技有限公司
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AI Technical Summary

Problems solved by technology

[0005] The technical problem mainly solved by the present invention: in the extraction process of ursolic acid in the current loquat leaf, not only the extraction process is long, time-consuming, the extract impurity content is high, the extraction efficiency is relatively low, and a large amount of solvents are used, there is also residual Problem and the problem of environmental pollution thereof, a kind of method of separating and purifying ursolic acid from loquat leaf is provided

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0019] (1) Wash 50-70g of fresh loquat leaves, remove dust and residue, drain the water and dry at 35-55°C;

[0020] (2) Put the dried loquat leaves into a pulverizer and pulverize them into 80-100 mesh powder;

[0021] (3) Mix 60-70g of ultra-fine calcium carbonate powder with a particle size of 1-3mm and 180-210mL of acetic acid evenly, and stir clockwise until it becomes viscous;

[0022] (4) Spray the viscous substance obtained above evenly with an air gun on the attapulgite with a particle size of 3-5mm, and adjust the temperature to 110-130°C, so that it can be completely immobilized on it after drying at high temperature;

[0023] (5) Immerse the above-mentioned attapulgite particles immobilized with viscous substances in 100-130 mL of hydrochloric acid with a mass concentration of 0.8 mol / L, and wait until it reacts until there are no bubbles to obtain hydrophilic organic matter. stick clay particles;

[0024] (6) Take 80-100g of the hydrophilic organic attapulgite p...

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Abstract

The invention relates to a method for separating and purifying ursolic acid from loquat leaves and belongs to the technical field of plant extraction. The method comprises the steps that firstly, calcium carbonate superfine powder and hydrophilia organic matter are immobilized on attapulgite; secondly, washing is carried out continuously to remove other impurities; finally, supercritical CO2 extraction is adopted for adsorbing and extracting ursolic acid out of a solution. The extracted ursolic acid is very high in extraction rate and is almost being purified, and the purpose of high concentration is achieved. It is proved through living examples that the method is novel, the extraction process of ursolic acid is shortened, and the extraction time is saved by more than 85%; in addition, the extraction rate reaches more than 99.99%, and the extracted matter is free of impurities and is close to the purified effect.

Description

technical field [0001] The invention relates to a method for separating and purifying ursolic acid from loquat leaves, belonging to the technical field of plant extraction. Background technique [0002] Loquat leaves are the leaves of Rosaceae plant loquat, slightly cold in nature, bitter and pungent in taste, relieve cough and asthma, clear lung and stomach, reduce qi and reduce phlegm, flowers, fruits, cores and other parts are rich in ursolic acid and oleanolic acid , amygdalin, saponins, flavonoids, water-soluble polysaccharides and organic acids and other active ingredients. At present, loquat is mainly supplied with fresh fruit, and the in-depth development and comprehensive utilization of other parts have not yet been carried out. [0003] Ursolic acid in loquat leaves is a kind of triterpenoid compound that exists in natural plants. It has obvious antioxidant function and has attracted widespread attention from the international community. It has been proved by sc...

Claims

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Application Information

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IPC IPC(8): C07J63/00
CPCY02P20/54
Inventor 雷春生张帆
Owner 杭州悦如森生物科技有限公司
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