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Phenobarbital orally disintegrating tablets and preparation method thereof

The technology of oral disintegrating tablets and phenobarbital is applied in the field of preparation of oral disintegrating tablets of phenobarbital, which can solve the problems of long survival, poor prognosis and the like, and achieve stable quality, good medication compliance and good appearance. Effect

Inactive Publication Date: 2015-12-16
HEFEI HUAFANG PHARMA SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, hormone therapy can also be used, but the prognosis of this disease is poor. After 3 months, the liver begins to cirrhosis, and dies of liver failure within 6 months to 2 years old. Only a few patients survive longer.

Method used

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  • Phenobarbital orally disintegrating tablets and preparation method thereof
  • Phenobarbital orally disintegrating tablets and preparation method thereof
  • Phenobarbital orally disintegrating tablets and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Each tablet contains phenobarbital 15mg, and the composition of 1000 phenobarbital orally disintegrating tablets is:

[0027]

[0028] The preparation method is as follows:

[0029] (1) Take phenobarbital by weighing, add a certain amount of purified water and stir, and use a pH regulator to control the pH between 6.5-7.5, as liquid a;

[0030] (3) Take by weighing the prescription amount of skeleton agent, binder, and corrective agent, add a certain amount of purified water to stir and dissolve, pass through a 100-mesh sieve, and use it as liquid b;

[0031] (4) Slowly add liquid b into liquid a under stirring, and stir for 10-20 minutes after adding liquid b; then use a pH regulator to control the pH between 6.5-7.5, and set aside;

[0032] (5) After the medicinal liquid measures the phenobarbital content, the medicinal liquid is subpackaged in the drug-containing dish, and the medicinal liquid-filled dish is put into a vacuum freeze-drying box to freeze-dry;

[...

Embodiment 2

[0036] Each tablet contains phenobarbital 15mg, and the composition of 1000 phenobarbital orally disintegrating tablets is:

[0037]

[0038] The preparation method is as follows:

[0039](1) Take phenobarbital by weighing, add a certain amount of purified water and stir, and use a pH regulator to control the pH between 6.5-7.5, as liquid a;

[0040] (3) Take by weighing the prescription amount of skeleton agent, binder, and corrective agent, add a certain amount of purified water to stir and dissolve, pass through a 100-mesh sieve, and use it as liquid b;

[0041] (4) Slowly add liquid b into liquid a under stirring, and stir for 10-20 minutes after adding liquid b; then use a pH regulator to control the pH between 6.5-7.5, and set aside;

[0042] (5) After the medicinal liquid measures the phenobarbital content, the medicinal liquid is subpackaged in the drug-containing dish, and the medicinal liquid-filled dish is put into a vacuum freeze-drying box to freeze-dry;

[0...

Embodiment 3

[0046] Each tablet contains phenobarbital 15mg, and the composition of 1000 phenobarbital orally disintegrating tablets is:

[0047]

[0048] The preparation method is as follows:

[0049] (1) Take phenobarbital by weighing, add a certain amount of purified water and stir, and use a pH regulator to control the pH between 6.5-7.5, as liquid a;

[0050] (3) Take by weighing the prescription amount of skeleton agent, binder, and corrective agent, add a certain amount of purified water to stir and dissolve, pass through a 100-mesh sieve, and use it as liquid b;

[0051] (4) Slowly add liquid b into liquid a under stirring, and stir for 10-20 minutes after adding liquid b; then use a pH regulator to control the pH between 6.5-7.5, and set aside;

[0052] (5) After the medicinal liquid measures the phenobarbital content, the medicinal liquid is subpackaged in the drug-containing dish, and the medicinal liquid-filled dish is put into a vacuum freeze-drying box to freeze-dry;

[...

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Abstract

The invention discloses phenobarbital orally disintegrating tablets and a preparation method thereof, and belongs to the field of preparation of phenobarbital orally disintegrating tablets. The invention firstly discloses phenobarbital orally disintegrating tablets which comprise the following components in parts by weight: 1-30 parts of phenobarbital, 60-95 parts of a framework material, 1-10 parts of an adhesive, 0.1-5 parts of a corrigent and a pH regulator. The phenobarbital orally disintegrating tablets provided by the invention are good in appearance, low in the friability, good in taste, short in melting time, quick in effect, convenient to carry and good in medication compliance.

Description

technical field [0001] The invention relates to orally disintegrating tablets, and also relates to a preparation method of the orally disintegrating phenobarbital tablets, which belongs to the field of preparing orally disintegrating phenobarbital tablets. Background technique [0002] In medicine, the jaundice of newborns under the full moon (within 28 days of birth) is called neonatal jaundice. It is a disease characterized by jaundice on the skin, mucous membranes and sclera. The disease can be divided into physiological and pathological. Physiological jaundice appears 2 to 3 days after birth, peaks at 4 to 6 days, subsides at 7 to 10 days, and lasts longer in premature infants. Except for a slight loss of appetite, there are no other clinical symptoms. If jaundice occurs 24 hours after birth, the daily serum bilirubin rises more than 5 mg / dl or >0.5 mg / dl per hour; the duration is long, full-term infants > 2 weeks, premature infants > 4 weeks and still persist,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/515A61K47/40A61K47/26A61P1/16
Inventor 何勇吴宗好高永好
Owner HEFEI HUAFANG PHARMA SCI & TECH
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