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Preparation method of polysaccharide-polyvinyl alcohol embolism microsphere

A technology of polyvinyl alcohol embolic microspheres and polyvinyl alcohol, which is applied in the preparation of interventional vascular embolization materials and the preparation of polysaccharide-polyvinyl alcohol embolic microspheres. Material lesions have not recovered, and the action time is uncontrollable, etc., to achieve the effects of convenient clinical application, uniform and controllable particle size, large scalability and elasticity

Active Publication Date: 2015-12-16
SHAANXI BOYU REGENERATIVE MEDICINE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The product has certain elasticity and expansibility, and the particle size is controllable. However, as a non-permanent embolic particle, the product’s action time on the embolic site is uncontrollable, and it is easy to see that the embolic material has been degraded and absorbed but the lesion has not recovered. situation, requiring multiple embolizations
[0007] In summary, the current vascular embolic materials are often difficult to control in clinical use due to liquid and granular embolic agents. At the same time, the existing embolic materials cannot achieve the control of embolization time according to clinical conditions, which requires multiple embolization treatments.

Method used

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  • Preparation method of polysaccharide-polyvinyl alcohol embolism microsphere

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preparation example Construction

[0034] The preparation method of the polysaccharide-polyvinyl alcohol embolization microspheres includes the following main processes: 1) preparation of blend solution; 2) emulsification and cross-linking; 3) washing, dehydration and drying; 4) sieving. Specific steps are as follows:

[0035] Step 1: Preparation of blend liquid: dissolve polyvinyl alcohol and polysaccharide natural polymer in water, stir with an electric stirrer at a stirring rate of 500-5000 rpm, and prepare a blend with a concentration of 1-30% (w / w) solution. Wherein, the mass ratio (w / w) of polysaccharide and polyvinyl alcohol is 1:0.01-3:1.

[0036] Among them, the polysaccharide natural polymer mainly includes pullulan, chitosan or carboxymethyl cellulose. The blending solution is blended with one of polyvinyl alcohol and polysaccharide macromolecule, and the different ratios of the two materials can control the action time of the embolic microspheres.

[0037] Among them, after blending chitosan and ...

Embodiment 1

[0051] Embodiment 1, chitosan-polyvinyl alcohol embolization microspheres

[0052] Step 1: Preparation of blend solution: dissolving polyvinyl alcohol and chitosan natural polymer in water, stirring with an electric stirrer at a stirring rate of 500-5000 rpm, and preparing 1000 ml of blend solution with a concentration of 10% (w / w). Wherein, the mass ratio (w / w) of chitosan and polyvinyl alcohol is 1:0.01, 1:0.1, 1:3, respectively.

[0053] Step 2: emulsification and crosslinking: Heat 500ml of the chitosan-polyvinyl alcohol blend prepared in step 1 to 90°C, stir at 5000rpm for 30min to dissolve it into a transparent liquid, and let stand to remove air bubbles. After dispersing 0.01% (w / w) Span80 and 500ml liquid paraffin evenly, add it dropwise to the liquid paraffin with a syringe, after stirring for 60 minutes, add 0.01% (w / w) glutaraldehyde with a syringe, Stirring was continued for 3h. At the same time, inject the remaining uncrosslinked blend in step 1 into the crossli...

Embodiment 2

[0056] Embodiment 2, starch-polyvinyl alcohol embolization microspheres

[0057] Step 1: Preparation of blend solution: Dissolve polyvinyl alcohol and starch in water, stir with an electric stirrer at a stirring rate of 1000 rpm, and prepare 1000 ml of blend solution with a concentration of 15% (w / w). Wherein, the mass ratio (w / w) of starch and polyvinyl alcohol is 0.1:1, respectively.

[0058] Step 2: emulsification and crosslinking: Heat 500ml of the starch-polyvinyl alcohol blend prepared in step 1 to 90°C, stir at 3000rpm for 20min to dissolve it into a transparent liquid, and let it stand to remove air bubbles. Disperse 0.02% (w / w) Span80 and 500ml liquid paraffin evenly, then add it dropwise into the liquid paraffin with a syringe, stir for 40 minutes, then add 0.02% (w / w) formaldehyde with a syringe, and keep stirring 6h. At the same time, the remaining uncrosslinked blend solution in step 1 is injected into the crosslinked solution into the crosslinked solution to fo...

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Abstract

The invention discloses a preparation method of a polysaccharide-polyvinyl alcohol embolism microsphere, wherein the polysaccharide-polyvinyl alcohol embolism microsphere is an elastic microsphere which is formed by blending and cross-linking polyvinyl alcohol and polysaccharide natural polymers. The preparation method comprises the following steps: blending polyvinyl alcohol and polysaccharide natural polymers so as to form polysaccharide-polyvinyl alcohol mixed liquids different in proportion; and partially cross-linking the mixed liquids, and emulsifying with uncross-linked part so as to obtain a cross-linked vascular thrombosis microsphere, namely the polysaccharide-polyvinyl alcohol embolism microsphere. The polysaccharide-polyvinyl alcohol embolism microsphere is relatively high in flexibility and elasticity and is convenient for delivering micro catheters, and the preparation method is simple; meanwhile, embolism cycle can be controlled in accordance with the situations of various tumor symptoms, so as to effectively avoid the circumstance of multiple embolisms; and the preparation method is convenient for clinical application.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and relates to a preparation method of a blood vessel embolization material for intervention, in particular to a preparation method of polysaccharide-polyvinyl alcohol embolization microspheres. Background technique [0002] Embolization therapy refers to the selective injection of embolic materials into the supply vessels of a certain diseased organ through a catheter, so as to occlude the corresponding blood vessels and interrupt the blood supply to achieve the purpose of treatment. The key technology of the treatment is to choose the appropriate embolization agent To block the blood supply of diseased tissue. At present, this treatment method is mainly used for the treatment of various tumors and vascular lesions, as well as the treatment of acute bleeding such as postpartum hemorrhage. At the same time, depending on the pathological condition to be treated, embolization can be formed for ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/04A61L31/14
Inventor 尹晓刚
Owner SHAANXI BOYU REGENERATIVE MEDICINE CO LTD
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