Preparation technology of high-content compound herba houttuyniae mixture

A compound Houttuynia cordata and a preparation process technology are applied in the directions of medical preparations, drug combinations, and pharmaceutical formulations containing active ingredients, which can solve the problems of poor drug stability, poor clinical efficacy, and low content of medicinal components, and achieve solvent Less dosage, fine precipitation, avoiding the effect of a large amount of accumulation

Active Publication Date: 2015-12-23
浙江康恩贝中药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] The purpose of the present invention is to provide a preparation process of high-content compound Houttuynia mixture, which solves the technical

Method used

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  • Preparation technology of high-content compound herba houttuyniae mixture
  • Preparation technology of high-content compound herba houttuyniae mixture
  • Preparation technology of high-content compound herba houttuyniae mixture

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Embodiment 1: the preparation of compound Houttuynia cordata mixture A

[0038] Prescription (contains main medicinal materials and excipients):

[0039]

[0040] Preparation:

[0041] (1) Flash extraction: According to the prescription ratio of the above-mentioned compound Houttuynia cordata mixture, take 500 g of Houttuynia cordata, add 8 times the volume of 50% ethanol solution to soak for 1 hour, and then perform flash extraction. The flash extraction time is 2 minutes, and the flash extraction speed is 4500 rpm. Filter , the dregs were extracted once more, and the combined filtrate was concentrated to a clear paste with a relative density of 1.08 (60°C);

[0042] (2) Steam distillation: according to the prescription ratio of the above-mentioned compound Houttuynia mixture, take 125g of Scutellaria baicalensis, 125g of Radix Radix, 50g of Forsythia, 50g of honeysuckle and the Houttuynia herb residue in step (1), add 11 times the volume of water to carry out Steam...

Embodiment 2

[0046] Embodiment 2: the preparation of compound Houttuynia cordata mixture B

[0047] Prescription (contains main medicinal materials and excipients):

[0048]

[0049]

[0050] Preparation:

[0051] (1) Flash extraction: According to the prescription ratio of the above-mentioned compound Houttuynia cordata mixture, take 500 g of Houttuynia cordata, add 5 times the volume of 70% ethanol solution to soak for 0.5 h, and then perform flash extraction. The flash extraction time is 1 min, and the flash extraction speed is 3500 rpm. Filtrate, repeat the extraction of the medicinal residue once more, and concentrate the filtrate to a clear paste with a relative density of 1.10 (80°C);

[0052] (2) Steam distillation: according to the prescription ratio of the above compound Houttuynia mixture, take 125g of Scutellaria baicalensis, 125g of Radix Isatidis, 50g of Forsythia, 50g of honeysuckle and the Houttuynia herba residue in step (1), add 8 times the volume of water to carry...

Embodiment 3

[0056] Embodiment 3: the preparation of compound Houttuynia cordata mixture C

[0057] Prescription (contains main medicinal materials and excipients):

[0058]

[0059] Preparation:

[0060] (1) Flash extraction: According to the prescription ratio of the above-mentioned compound Houttuynia cordata mixture, take 500g of Houttuynia cordata, add 6 times the volume of 30% ethanol solution to soak for 2 hours, then perform flash extraction, flash extraction time 5min, flash extraction speed 4000rpm, filter , and the dregs were repeatedly extracted twice, and the combined filtrate was concentrated to a clear paste with a relative density of 1.09 (80°C);

[0061] (2) Steam distillation: according to the prescription ratio of the above compound Houttuynia mixture, take 125g of Scutellaria baicalensis, 125g of Radix Isatidis, 50g of Forsythia, 50g of honeysuckle and the Houttuynia herba residue in step (1), add 10 times the volume of water to carry out Steam distilled for 1 hour...

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Abstract

The invention discloses a preparation technology of a high-content compound herba houttuyniae mixture. According to the invention, herba houttuyniae, radix scutellariae, radix isatidis, fructus forsythia and honeysuckle are used as main medicinal materials to prepare the high-content compound herba houttuyniae mixture. The mixture contains the following active medicinal components: 10-25 micrograms/ml of houttuynin, 50-100 micrograms/ml of quercitrin, 1-2 mg/ml of baicalin and 15-40 micrograms/ml of forsythin. The preparation technology comprises the following steps: (1) flash extraction; (2) steam distillation; (3) alcohol precipitation; (4) water precipitation; and (5) preparation of the mixture. By the preparation technology, contents of the active medicinal components such as houttuynin, quercitrin and the like in the compound herba houttuyniae mixture can be effectively increased. In addition, components such as polysaccharide, protein, tannin and the like in the medicinal materials can be removed. Thus, precipitates generated during selling and storing process are reduced, and stability and safety of the medicine are raised. Besides, the high-content compound herba houttuyniae mixture can effectively treat throat pain caused by wind-heat common cold and acute pharyngitis and tonsillitis if used separately.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and in particular relates to a preparation process of high-content compound Houttuynia cordata mixture, which is mainly used for treating sore throat, acute pharyngitis and tonsillitis caused by exogenous wind-heat. Background technique [0002] Compound Houttuynia Herba Mixture, as a traditional Chinese medicine, is included in the National Drug Standards. Its prescription composition and preparation method are as follows: [0003] Prescription: Houttuynia cordata 100g Scutellaria baicalensis 25g Banlangen 25g Forsythia 10g Honeysuckle 10g Sucrose 60g Honey 200g Sodium benzoate 2g Ethylparaben 0.5g [0004] Made: 1000ml [0005] Preparation method: decoct the above five medicinal materials with water twice, 2 hours each time, combine the decoction liquid, filter, concentrate the filtrate to a clear paste with a relative density of 1.18-1.20 (60°C-80°C), add ethanol to precipitate St...

Claims

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Application Information

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IPC IPC(8): A61K36/78A61P11/04A61P11/00
Inventor 王建方姚建标印晓红吴健王如伟金汉台陈卿兰文一
Owner 浙江康恩贝中药有限公司
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