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Pharmaceutical composition for preventing and treating piglet yellow-white dysentery

Piglet yellow and white scour, composition technology, applied in the direction of drug combination, active ingredients of heterocyclic compounds, antibacterial drugs, etc., can solve the problems of piglets coughing and panting, excessive reaction, weak drug tolerance, etc., and achieve high bioavailability , high safety factor, less resistant to drugs

Active Publication Date: 2015-12-23
FUJIAN AONONG BIOLOGICAL TECH GRP CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Second, the dosage is not well controlled
Suckling piglets are small and have weak tolerance to drugs. If the drug is overdose, there may be a serious overdose reaction, and if it is insufficient, the preventive and therapeutic effects will not be achieved.
Weighing the body weight before administration will increase the workload a lot, so it is not advisable
[0005] The third is to increase the burden on liver and kidney
[0006] Fourth, it is easy to cause respiratory tract infection
Oral administration, because liquid medicine has good fluidity, it is easy to enter the trachea through the throat, causing piglets to cough and pant, and even respiratory tract infection in severe cases
At the same time, it will lead to insufficient dose of the drug entering the gastrointestinal tract and cannot exert therapeutic effect.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] 1 part of neomycin sulfate, 0.5 parts of colistin sulfate, 2.5 parts of bacitracin zinc, 25 parts of sucrose, 22 parts of starch, 0.6 parts of sodium benzoate, 10.05 parts of vitamin B, 0.01 parts of vitamin B2, 0.05 parts of vitamin B6 , 1 part of nicotinamide, 0.01 part of sodium d-pantothenate. The processing technology is as follows: take a certain amount of water to dissolve the water-soluble drug, then mix it with gelatinized starch and insoluble components, set the volume to a certain volume, so that the content of neomycin reaches 10 mg / ml, and then grind it through a colloid mill to produce suspension.

[0019] The prepared suspension was used for clinical trials (experimental group), and oral administration was carried out to 3-10-day-old suckling piglets with symptoms of yellow and white scour, at 5ml / head. Because of the good palatability, the The piglets did not show discomfort symptoms such as vomiting, coughing, panting, etc., and the diarrhea symptoms w...

Embodiment 2

[0023] Neomycin sulfate 2 parts, colistin sulfate 0.5 parts, bacitracin zinc 2.5 parts, sucrose 20 parts, starch 40 parts, sodium benzoate 0.6 parts, vitamin B10.03 parts, vitamin B20.02 parts, vitamin B60.05 parts , 0.75 parts of nicotinamide, and 0.025 parts of sodium d-pantothenate.

[0024] The processing technology is as follows: take a certain amount of water to dissolve the water-soluble drug, then mix it with gelatinized starch and insoluble components, set the volume to a certain volume, so that the neomycin content reaches 20mg / ml, and then grind it through a colloid mill to make a paste agent.

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PUM

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Abstract

The invention discloses a pharmaceutical composition for preventing and treating piglet yellow-white dysentery. The pharmaceutical composition is prepared from the following raw materials in parts by weight: 1-5 parts of neomycin sulfate, 0.3-2.5 parts of colistin sulfate, 2.5-12.5 parts of bacitracin zinc, 15-35 parts of sucrose, 21-40 parts of starch, 0.1-1 part of sodium benzoate, 0.05-0.1 part of vitamin B1, 0.01-0.06 part of vitamin B2, 0.01-0.05 part of vitamin B6, 0.5%-1% of nicotinamide and 0.01%-0.05% of sodium dextropantothenate. The composition is prepared into paste, thick paste, suspension or clinically acceptable dosage forms in veterinary medicine through processing. Through the composition and an application method and the dosage of the composition, the pharmaceutical composition has a specific treatment effect on the piglet yellow-white dysentery.

Description

technical field [0001] The invention relates to a pharmaceutical composition for preventing and treating yellow and white scour of piglets, which belongs to the field of veterinary preparations and is mainly used for preventing and treating yellow and white scour of piglets. Background technique [0002] Piglet yellow and white scour is a common disease in pig farms, with an incidence rate of up to 80%. Especially with the current changes in breeding scale and breeding density, the incidence rate is on the rise, and in some places it has reached 100%. Although the mortality rate of piglets with yellow and white scour is not high (if management is not in place or handled properly, the mortality rate will be high), but piglets are at the forefront of the breeding cycle, and piglets with yellow and white scour will seriously affect their health and overall quality. seriously affect the overall economic performance. Therefore, the breeding enterprises will take various measures...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/12A61P1/12A61P31/04A61K31/7036A61K31/197A61K31/4415A61K31/455A61K31/51A61K31/525
Inventor 梁世仁戴多亮王庆福胡鹏飞陈民中黄静
Owner FUJIAN AONONG BIOLOGICAL TECH GRP CO LTD
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