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A kind of preparation method of anticancer traditional Chinese medicine sugar-free granule

A technology for granules and traditional Chinese medicine, applied in the field of medicine, can solve the problems of large loss of effective components, low extraction rate, and many processes, and achieve the effects of improving extraction rate, improving economic benefits, and stable physical properties

Active Publication Date: 2018-05-22
山西振东五和堂制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, commonly used extraction methods (such as decoction, reflux, maceration, Percolation etc.) In terms of retaining active ingredients and removing ineffective ingredients, there are disadvantages such as large loss of active ingredients, long cycle, many processes, and low extraction rate.

Method used

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  • A kind of preparation method of anticancer traditional Chinese medicine sugar-free granule
  • A kind of preparation method of anticancer traditional Chinese medicine sugar-free granule
  • A kind of preparation method of anticancer traditional Chinese medicine sugar-free granule

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] A preparation method of anticancer traditional Chinese medicine sugar-free granules, the steps are:

[0047] (1) Accurately weigh the following components by weight: Scutellaria baicalensis 5Kg, Epimedium 4Kg, Ligustrum lucidum 5Kg, Polygonum multiflorum 4Kg, Rehmannia glutinosa 4Kg, Rubia 3Kg, Polygonatum 4Kg, Ginseng 1Kg;

[0048] (2) Mix and grind Scutellaria baicalensis and ginseng into 100-200 mesh coarse powder, and use supercritical CO 2 Extraction method extraction, extraction pressure 20~30MPa, extraction temperature 40℃~45℃, extraction time 5h, entrainer is 70% anhydrous ethanol, entrainer volume is 2 times, collect the extract, and collect the dregs in another device;

[0049] (3) Extract the dregs collected in step (2) by microwave method, which is to add water 20 times the weight of dregs to the dregs, soak for 2 hours, and treat the dregs with microwave power for 1 min under the condition of microwave power 200W, then collect the extract , the dregs are c...

Embodiment 2

[0054] A preparation method of anticancer traditional Chinese medicine sugar-free granules, the steps are:

[0055] (1) Accurately weigh the following components by weight: Scutellaria baicalensis 5Kg, Epimedium 4Kg, Ligustrum lucidum 5Kg, Polygonum multiflorum 4Kg, Rehmannia glutinosa 4Kg, Rubia 3Kg, Polygonatum 4Kg, Ginseng 1Kg;

[0056] (4) Mix and grind Scutellaria baicalensis and ginseng into 100-200 mesh coarse powder, and use supercritical CO 2 Extraction method extraction, extraction pressure 25 ~ 30MPa, extraction temperature 35 ℃ ~ 40 ℃, extraction time 2h, entrainer is 40% absolute ethanol, the volume of entrainer is 2.5 times, the extract is collected, and the dregs are collected in a separate device;

[0057] (5) Extract the medicinal dregs collected in step (2) by microwave method, which is to add water 30 times the weight of medicinal dregs to the medicinal dregs, soak for 3 hours, and microwave for 5 minutes under the condition of microwave power 100W, then col...

Embodiment 3

[0062] A preparation method of anticancer traditional Chinese medicine sugar-free granules, the steps are:

[0063] (1) Accurately weigh the following components by weight: Scutellaria baicalensis 5Kg, Epimedium 4Kg, Ligustrum lucidum 5Kg, Polygonum multiflorum 4Kg, Rehmannia glutinosa 4Kg, Rubia 3Kg, Polygonatum 4Kg, Ginseng 1Kg;

[0064] (6) Mix and crush Scutellaria baicalensis and ginseng into 100-200 mesh coarse powder, and use supercritical CO 2 Extraction method extraction, extraction pressure 30-40MPa, extraction temperature 45°C-50°C, extraction time 4h, entrainer is 60% absolute ethanol, entrainer volume is 2.5 times, the extract is collected, and the dregs are collected in a separate device;

[0065] (7) Extract the medicinal dregs collected in step (2) by microwave method, which is to add water 35 times the weight of medicinal dregs to the medicinal dregs, soak for 1 hour, and microwave for 3 minutes under the condition of microwave power 150W, then collect the ext...

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Abstract

The invention discloses a preparation method of anticancer traditional Chinese medicine sugar-free granules, belongs to the technical field of medicine and relates to Chinese patent medicines. The steps are: (1) Accurately weigh the following components in parts by weight: Scutellaria baicalensis 5, Epimedium 4, Ligustrum lucidum 5, Polygonum multiflorum 4, Rehmannia glutinosa 4, Rubia 3, Polygonatum 4, Ginseng 1; (2) Scutellaria baicalensis Mix and pulverize with ginseng and extract by supercritical CO2 extraction; (3) Extract the dregs by microwave method; (4) Mix Epimedium, Ligustrum lucidum, Rehmannia glutinosa, madder, Polygonatum, Polygonum multiflorum, and then mix with dregs Mix, soak in water and decoct; (5) Combine the extract, extract, and decoction, filter, add ethanol solution, settle still to remove alcohol-insoluble matter, and concentrate under reduced pressure to obtain a clear paste; (6) Clear the paste according to Granules are made by conventional methods and dried. The method of the invention has a high extraction rate of the medicine, and the content of impurities in the extract is low, and the bioavailability of the medicine is high.

Description

technical field [0001] The invention belongs to the technical field of medicines, relates to Chinese patent medicines, in particular to a preparation method of anticancer traditional Chinese medicine sugar-free granules. Background technique [0002] Tumor is a malignant disease that seriously endangers human health. In my country, the number of deaths due to malignant tumors accounts for 17.9% of the total number of deaths in the country every year. For a long time, the main methods of diagnosis and treatment of malignant tumors are surgery or radiotherapy and chemotherapy, but there are not only the problems of low cure rate and high recurrence rate, but also side effects such as systemic immune function loss and increased gastrointestinal functional reactions of patients caused by radiotherapy and chemotherapy. very big. Traditional Chinese medicine has a long history, and it is a precious wealth summed up from long-term practice by medical scientists, doctors and people...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/16A61K36/8969A61P35/00
Inventor 王六贵吕建英王晓艳宋向梅赵衍慧
Owner 山西振东五和堂制药有限公司
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