Medicinal preparation for resisting left ventricular hypertrophy and application of medicinal preparation
A pharmaceutical preparation and left ventricle technology, applied in the field of medicine, can solve the problems of lifelong medication obstacles of patients with side effects, and achieve the effects of moderate price, simple preparation process, and improvement of different symptoms
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Embodiment 1
[0013] Embodiment 1: the preparation of Chinese medicine dry plaster powder
[0014] Weigh 1.2kg of incense, 3.0kg of evening primrose, 1.4kg of horse locust fruit, 1.4kg of Buddha's nail, 2.1kg of Ophiopogon japonicus, 0.9kg of weed flower root, 1.2kg of narcissus flower, and 0.8kg of lovage, add water and decoct twice , add 120L of purified water for the first time, decoct for 2h, add 110L of purified water for the second time, decoct for 1.5h, combine the decoction, concentrate under reduced pressure at 0.08MPa, 70°C to 70°C when the relative density is 1.15, add 95 % ethanol to make the alcohol content reach 75% (v / v), stir, stand overnight, filter, and the filtrate is concentrated under reduced pressure at 0.08MPa and 65°C to become an extract with a relative density of 1.25 at 65°C. Put it in a stainless steel pan, vacuum dry (below 60°C) into a dry paste, and crush it.
Embodiment 2
[0015] Embodiment 2: the preparation of Chinese medicine tablet
[0016] Weigh 100g of Chinese medicine extract dry powder (prepared by the formula process of Example 1), pass through a 100 mesh sieve, then add 400g of dextrin and 200g of microcrystalline cellulose crossed through an 80 mesh sieve, mix uniformly, and add an appropriate amount of 75% Ethanol solution is used as a binder, and wet granulation is adopted, that is, the wet granules are made through a 32-mesh sieve, and the wet granules are fully dried at 55°C, and the granules are sized. Add an appropriate amount of talcum powder to the dry granules, mix evenly, and directly compress the tablet. , get Chinese medicine tablet.
Embodiment 3
[0017] Example 3: Study on the Effect of Chinese Medicine Dry Paste Powder on Isoproterenol-induced Myocardial Hypertrophy in Mice
[0018] 48 Kunming mice, half male and half female, weighing 20-22 g, were randomly divided into four groups, 12 mice in each group, namely: normal group, model group and high and low dose groups of traditional Chinese medicine. Except for the normal group, the other groups used isoproterenol to prepare the mouse myocardial hypertrophy model, the method is as follows: 2 mg / (kg d) of isoproterenol was subcutaneously injected on the back for 7 consecutive days, 1 time / d, and the myocardial hypertrophy model was established. ; The mice in the normal group were subcutaneously injected with the same amount of normal saline on the back in the same way. Each administration group was given the corresponding test substance on the second day after giving the injection of isoproterenol, and the Chinese medicine high and low dose groups were fed with 480 and ...
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