Preparation method and application of magnetic MIL-100 composite material

A composite material and magnetic technology, which is applied in the field of preparation of magnetic MIL-100 composite materials, can solve the problems of difficult comparative analysis, time-consuming, high cost, etc.

Inactive Publication Date: 2015-12-30
TIANJIN POLYTECHNIC UNIV
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Problems solved by technology

Serum proteins are very complex. One challenge of serum proteomic analysis is that the dynamic range of serum protein concentration spans about 10-12 orders of magnitude. Another challenge is that the presence of high-abundance proteins can suppress the mass spectrometry signal of other serum proteins.
Therefore, the specificity and complexity of serum protein composition determine that the pretreatment steps of mass spectrometry are cumbersome, laborious, time-consuming, and costly, and it is difficult to carry out comparative analysis of large groups

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  • Preparation method and application of magnetic MIL-100 composite material
  • Preparation method and application of magnetic MIL-100 composite material

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Embodiment Construction

[0023] The technical solution of the present invention will be further described below through examples.

[0024] A kind of preparation method of magnetic MIL-100 composite material, described magnetic MIL-100 composite material is Fe 3 o 4 / CMIL-101, where MIL-100 is a metal-organic framework material constructed from iron and trimesic acid, and the synthesis steps are as follows:

[0025] 1) Carbon layer-coated magnetic microspheres (Fe 3 o 4 / C) preparation

[0026] 200mgFe 3 o 4 Add microspheres to 40mL0.1molL -1 HNO 3 solution, after ultrasonic treatment for 10 min, washed with distilled water until neutral, and then Fe 3 o 4 Microspheres dispersed in 40mL0.4molL -1 In the aqueous glucose solution, the obtained mixed solution was transferred to an autoclave, and reacted for 4 hours at a temperature of 180 ° C. After the reaction was completed, magnetic separation was performed, and the obtained Fe 3 o 4 / C magnetic microspheres were washed with ultrapure water...

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Abstract

The invention provides a preparation method and application of a magnetic MIL-100 composite material. The magnetic MIL-100 composite material is Fe3O4/C@MIL-100, wherein the MIL-100 is a metal-organic framework material constructed by iron and trimesic acid. A synthesis method comprises the following steps: firstly, preparing a carbon layer clad magnetic microsphere and preparing the Fe3O4/C@MIL-100 composite material. The prepared magnetic MIL-100 composite material is used for finding and detecting a blood serum biomarker. The preparation method and the application, provided by the invention, have the advantages that a carbon layer is ingeniously and uniformly clad on the surface of a high-quality Fe3O4 microsphere by the preparation method, and the Fe3O4/C@MIL-100 composite material is prepared in situ by a one-pot method; the composite material has a magnetic separation property of magnetic nano particles and a size exclusion effect of MIL-101; and high-abundant protein does not need to be removed, and the composite material can be rapidly and efficiently suitable for finding and detecting the blood serum biomarker.

Description

technical field [0001] The invention relates to the preparation of a magnetic metal-organic framework composite material, in particular to a preparation method and application of a magnetic MIL-100 composite material. Background technique [0002] Metal-organic frameworks (MOFs) are a new type of organic-inorganic hybrid porous materials with a pore structure. In the past fifteen years, it has attracted extensive attention of scientific researchers, and composite materials based on MOFs have become a focus of attention. In the process of self-assembly of MOFs materials, the properties and structures of MOFs are regulated by using nanometer or microparticles, endowing them with optical, magnetic and catalytic properties, thus producing new, hybrid and multifunctional mesoporous composite materials, namely MOFs. composite material. [0003] As one of the most common water-stable MOFs materials, MIL-100 has excellent properties such as high specific surface area, uniform poro...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N1/40G01N21/62
Inventor 黄艳凤魏纪平陈丹丹
Owner TIANJIN POLYTECHNIC UNIV
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