A Microfluidic Chip System for Improving the Irradiation Flux of a Single Ion Beam

A microfluidic chip and single ion beam technology, applied in color/spectral characteristic measurement, fluorescence/phosphorescence, material excitation analysis, etc., can solve problems such as low radiation flux, inability to detect in situ online, and eliminate toxicity , The experimental data is stable and reliable, and the irradiation parameters are consistent

Active Publication Date: 2018-03-23
HEFEI INSTITUTES OF PHYSICAL SCIENCE - CHINESE ACAD OF SCI
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Problems solved by technology

[0005] The technical problem to be solved by the present invention is to provide a microfluidic chip system for increasing the irradiation flux of a single ion beam and its use method, so as to overcome the low irradiation flux of the existing single ion beam device and the inability to detect in situ on-line technical flaws

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  • A Microfluidic Chip System for Improving the Irradiation Flux of a Single Ion Beam

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Embodiment Construction

[0015] The technical solutions of the present invention will be further specifically described below in conjunction with specific embodiments.

[0016] Such as figure 1 As shown, the microfluidic chip system used to increase the irradiation flux of a single ion beam is placed above the beam irradiation outlet, and glass is used as the substrate material of the microfluidic chip. The microfluidic chip has a culture medium reservoir , microchannels, real-time detection of cell electrodes, irradiation points, filters, cell pools and other functional structures. The front end of the medium storage tank is connected with a multi-channel drive pump, which is used to drive the medium suspension forward and inject CO into the medium. 2 and O 2 , to regulate the acid-base balance and oxygen content of the medium to meet the conditions for cell survival. The drive system can quickly drive the microfluidics to make steady motion or stand still. The microchannel and the reservoir are ...

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Abstract

The invention discloses a microfluidic chip system for improving the irradiation flux of a single ion beam, which includes a culture medium storage tank and a microchannel. The microchannel only allows a single cell to move forward in a queue, and real-time detection is installed on both sides of the microchannel. Cell electrode, real-time detection There is a radiation point in front of the cell electrode, and the thickness of the radiation point does not exceed 5 μm; real-time detection of the differential signal generated by the cell electrode pair, and the change of microfluidic impedance in the channel is detected by signal processing technology to quickly identify whether the cell passes or not, the cell The identification signal is connected to the beam control system of the single ion beam device, so that when the cells pass through the irradiation point, the beam control system can control the ions to irradiate the cells in a timely and accurate manner. For the first time in the invention, microfluidics is used in a single ion beam irradiation device, and the irradiation flux is increased by several tens of times, which meets the needs of a large amount of cells in biological experiments, and provides a new high-throughput technology platform for radiation biology. It has potential commercial application prospects.

Description

technical field [0001] The invention belongs to the field of microfluidic chip systems, and in particular relates to a microfluidic chip system for improving the irradiation flux of a single ion beam and an application method thereof. Background technique [0002] Cell biology experiments (such as genetic mutation research) require tens of thousands of cell samples. On the one hand, the experimental data is required to be statistically significant, and unstable and accidental factors are excluded; on the other hand, in each cell experiment, a large number of cells need to be tested in many ways. In addition, the cells have apoptosis failure, so a large number of cells to complete the experiment. High-throughput detection technology can make the experimental conditions of each cell sample more consistent, make the experimental data more authentic and reliable, and significantly improve the experimental efficiency. [0003] However, due to technical limitations, the irradiat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/25G01N21/64
Inventor 詹福如吴李君陈连运卞坡黄青袁航
Owner HEFEI INSTITUTES OF PHYSICAL SCIENCE - CHINESE ACAD OF SCI
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