Antibacterial micro- and nano-particles containing chlorhexidine salt and methods of making and using the same
A nanoparticle, antimicrobial technology, applied in botanical equipment and methods, medical preparations containing active ingredients, paints containing biocides, etc., can solve problems such as unsatisfactory release curves
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[0106] Preparation method of antimicrobial nanoparticles
[0107] In a further aspect of the present invention there is provided a process for the preparation of antimicrobial MNPs as described herein, the process comprising: reacting an aqueous solution of CHX cation with an oxoacid anion selected from phosphorus, carbon, nitrogen and sulfur and a partially hydrogenated One or more of the oxyacid anions of phosphorus, carbon, nitrogen and sulfur react. Preferably, the anion is selected from oxyacid anions of phosphorus, carbon, nitrogen and sulfur, more preferably, the anion is selected from at least one of phosphate, carbonate, nitrate and sulfate. The mixing is preferably carried out at a molar ratio of CHX cations to selected anions of 1:100 to 100:1 to prepare a colloidal suspension of micro- or nanoparticles.
[0108] Preferably, the two reactants are present in equimolar concentrations, ie 50:50. At equimolar reactant concentrations, the product colloidal suspension...
Embodiment 1-6
[0125] Embodiment 1-6; Comparative example 1-3 : CHX Elution from Functionalized Borosilicate Glass Surface
[0126] Each component produced by mixing 100 mL of chlorhexidine (like an aqueous solution of digluconate at a concentration of 10 mM) with 100 mL of one of a series of aqueous anionic solutions (also at an initial concentration of 10 mM) at room temperature with rapid agitation The final total concentration is 5mM) combined to prepare chlorhexidine-based salts. The anions used are listed in Table 1.
[0127] Table 1
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[0129]
[0130] The precipitate was then adhered to borosilicate glass slides. Slides were cleaned by sonicating for 10 minutes in acetone, then 10 minutes in industrial methylated spirits (Agar Scientific, Stansted, UK) and air dried. These slides were dipped into 200 mL of the suspension as described above while stirring the suspension rapidly using a magnetic stirrer. Slides were dipped for 30 seconds, removed, rinsed by immersion...
Embodiment 1
[0138] Example 1 - CHX-orthophosphate
[0139] CHX-orthophosphate (CHX-OP) functionalized samples showed some regions with self-assembled porous matrix deposition, and in figure 1 b and image 3 The unusual structure is also shown in a. These structures all consist of an arrangement of elongated crystals that originate at a central point and extend radially from that point ("hedgehog" shape). These structures are typically 30-50 μm in diameter and individual crystals are approximately 0.50-1 μm wide. These crystals are often slightly curved.
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