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A kind of traditional Chinese medicine composition for treating pulmonary fibrosis and preparation method thereof

A technology of pulmonary fibrosis and composition, which is applied in the application field of diseases, can solve problems such as adverse reactions, and achieve the effect of small side effects and remarkable therapeutic effect

Active Publication Date: 2018-06-26
INST OF MEDICINAL PLANT DEV CHINESE ACADEMY OF MEDICAL SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, chemical drugs have many side effects in the treatment of pulmonary fibrosis. They can inhibit the inflammatory response and immune process, reduce alveolar inflammation, and thus delay the process of pulmonary fibrosis. Important topics in pharmaceutical research

Method used

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  • A kind of traditional Chinese medicine composition for treating pulmonary fibrosis and preparation method thereof
  • A kind of traditional Chinese medicine composition for treating pulmonary fibrosis and preparation method thereof
  • A kind of traditional Chinese medicine composition for treating pulmonary fibrosis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Pharmacological examples of prescription effectiveness

[0043] 1. Intervention effect of prescription on fibrosis model mice caused by bleomycin

[0044] Experimental animals: male KM mice, weighing 18-22g, animal production license number: SCXK-007.

[0045] Animal model construction:

[0046] (1) Animal grouping: The experimental mice were randomly divided into 6 groups, 10 in each group. Set as blank control group, model group, and positive control group [dexamethasone group (Tianjin Lisheng Pharmaceutical Co., Ltd.), pirfenidone group, 50mg / kg / d (prifenidone)] and the administration component is low (Crude drug 3g / kg), medium (crude drug 6g / kg), high (crude drug 12g / kg) 3 dose groups. Among them, Angelica: Sophora flavescens: Licorice = 2:1:1.

[0047] (2) Modeling method: puncture and inject bleomycin into the space of the tracheal cartilage ring according to the gas weight of 3mg / kg. Immediately turn the animal upright and rotate for 2 minutes to make the drug solution ...

Embodiment 2

[0072] Extraction Example-Extraction Example 1

[0073] Prescription: Angelica 800g, Sophora flavescens 600g, Licorice 500g

[0074] Preparation:

[0075] 1) Weigh 800g of Angelica sinensis to extract the volatile oil by steam distillation for later use, and then concentrate and dry the residual Angelica sinensis aqueous solution under reduced pressure to obtain an extract;

[0076] 2) Mix the dregs of angelica with its extract, 600g of Sophora flavescens, 500g of licorice, and then reflux with 60% ethanol for 3 times, 1 hour each time, the ratio of material to liquid is 1:10:8:8, and concentrate under reduced pressure to obtain the leaching The paste (relative density 1.1-1.2) is spray dried into dry powder;

[0077] 3) The extracted volatile oil and the dry powder are uniformly mixed to form a powder.

[0078] Extraction Example 2

[0079] Prescription: Angelica 2000g, Sophora flavescens 1000g, Licorice 1000g

[0080] Preparation:

[0081] 1) 2000g of Angelica sinensis volatile oil is ex...

Embodiment 3

[0085] Prescription: Angelica 120g, Sophora flavescens 40g, Licorice 50g

[0086] Preparation method: the medicinal materials with the above weight ratio were prepared according to the method of extraction example 1, wherein the ethanol concentration was 70%.

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Abstract

The invention provides a traditional Chinese medicine composition, a preparation method thereof and application of the traditional Chinese medicine for treating pulmonary fibrosis and other diseases and belongs to the field of traditional Chinese medicine. The traditional Chinese medicine composition is prepared from, by weight, 1-20 parts of angelica sinensis, 1-10 parts of radix sophorae flavescentis and 5 parts of liquorice. The traditional Chinese medicine composition can be used for preparing medicine for treating pulmonary fibrosis and other diseases.

Description

Technical field [0001] The invention provides a traditional Chinese medicine composition and a preparation method thereof, and its application in treating diseases such as pulmonary fibrosis, and belongs to the field of traditional Chinese medicine. Background technique [0002] Lung interstitial tissue is composed of collagen, elastin and proteoglycan. Collagen is the main extracellular matrix (ECM) protein in lung tissue. Collagen in lung and other types of ECM components form a three-dimensional network. The structure becomes the main skeleton of lung tissue structure. These protein components maintain the integrity of lung tissue structure. It also plays a very important role in maintaining the differentiation state of lung epithelial and endothelial cells. When lung fibroblasts are damaged chemically (for example, bleomycin, allergen) or physical (for example, dust, radiation), they secrete collagen to repair the lung interstitial tissue, thereby causing lung fibrosis. The...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/489A61P11/00
Inventor 邹忠梅李玉明陈虹张宏武高颖贾红梅曹波赵洋丁刚
Owner INST OF MEDICINAL PLANT DEV CHINESE ACADEMY OF MEDICAL SCI