A kind of 2-methylimidazole curing agent and preparation method thereof
A technology of methylimidazole and methylimidazole, applied in the field of 2-methylimidazole curing agent and its preparation, can solve the problems of short storage time, etc., and achieve the effect of easy popularization and simple and feasible preparation method
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Embodiment 1
[0034] Example 1: Preparation of 7-methylcoumarin
[0035] Mix m-cresol (20ml, 0.19mol) with malic acid (25.4g, 0.19mol), add 98% mass fraction of concentrated sulfuric acid (20.9g) dropwise under ice water bath, stir at room temperature for 0.5h, and then heat to 120 React at °C for 3h until no gas escapes. Cool, pour into a mixture of ice and water, extract with 250ml ethyl acetate for multiple times, combine the organic layers, wash with water, and anhydrous NaSO at room temperature 4 Dry for 18h, evaporate the solvent at 80°C, and recrystallize with 95% ethanol to obtain white needle-like crystals (12.5g, yield 43%), melting point 125-128°C.
Embodiment 2
[0036] Example 2: Preparation of 7-bromomethylcoumarin
[0037] Mix 7-methylcoumarin 1b (1g, 6.25mmol), NBS (1g, 5.62mmol), benzoyl peroxide (0.01g), 20ml of dry benzene, reflux at 80°C for 6h, and evaporate to dryness at 80°C Solvent, wash with hot water, and recrystallize with glacial acetic acid to obtain white needle-like crystals (0.6 g, yield 40%), with a melting point of 178-180°C.
Embodiment 3
[0038] Example 3: Preparation of 2-methylimidazole curing agent
[0039] 2-methylimidazole (0.19g, 2.32mmol), NaH (0.18g, 7.5mmol), DMF 10ml, stir at room temperature, add 7-bromomethylcoumarin (0.5g, 2.10mol), heat to 70°C, react 2h, cool, pour into water, extract with 50ml ethyl acetate, wash with saturated sodium chloride solution, dry with anhydrous magnesium sulfate, spin dry, recrystallize from methanol to obtain a pale yellow solid (0.13g, yield 26%), melting point 198~205℃. IR(KBr)vcm-1: 3434, 1638, 1593, 1442, 1301, 744, ESI-MS: 263[M+Na]+, 1HNMR: 2.45(3H, s, -CH3), 2.90(2H, s, -CH2), 6.11 ~ 6.14 (1H, d, -CH = C), 6.47 ~ 6.49 (1H, d, ArH), 7.01 ~ 7.05 (2H, d, ArH), 7.23 ~ 7.30 (3H, m, -CH =C), 7.73 (1H, S, -CH=N), 13.45 (1H, s, -NH).
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