Bupropion hydrochloride sustained-release capsule and preparation method thereof

A technology of bupropion hydrochloride and sustained-release capsules, which is applied in the fields of pharmaceutical formulations, medical preparations containing active ingredients, and drug delivery, and can solve the problems of gastrointestinal peristalsis rate, obvious individual differences, and poor curative effect To achieve the effects of reducing the incidence of adverse reactions, stabilizing changes in blood drug concentration, and reducing the number of medications

Active Publication Date: 2016-01-27
上海爱的发制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, excessive application of ordinary tablets may cause epilepsy (incidence rate is about 0.4%)
However, the existing sustained-release tablets are skeleton sustained-release tablets made of high viscosity or water-insol

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0013] The preferred embodiments of the present invention are given below to describe the technical solution of the present invention in detail.

[0014] The bupropion hydrochloride sustained-release capsule of the present invention is made up of the following components, calculated by weight percentage, 62.50% bupropion hydrochloride, 6.25% tartaric acid, 9.26% sugar pills, 4.17% povidone K30 (referred to as PVPK30), 6.94% palmitic acid stearate, 0.46% acrylic resin RS100, 9.26% acrylic resin NE30D, 0.93% talc, 0.23% yellow iron oxide. Tartaric acid is a stabilizing agent to keep the stability of bupropion hydrochloride in the preparation. Povidone K30 and acrylic resin RS100 are used as adhesives. Glyceryl Palmitate Stearate is used in the barrier coating. Acrylic resin NE30D is used for sustained release coating. Talc is a lubricant. Yellow iron oxide is a coloring agent.

[0015] The preparation method of bupropion hydrochloride sustained-release capsules of the prese...

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Abstract

The invention discloses a bupropion hydrochloride sustained-release capsule and a preparation method thereof. The bupropion hydrochloride sustained-release capsule consists of the following components in percentage by weight: 62.50% of bupropion hydrochloride, 6.25% of tartaric acid, 9.26% of rotula, 4.17% of povidone K30, 6.94% of glyceryl palmitostearate, 0.46% of acrylic resin RS100, 9.26% of acrylic resin NE30D, 0.93% of talcum powder and 0.23% of yellow ferric oxide. The bupropion hydrochloride sustained-release capsule is uniform and stable in releasing, after a patient orally takes the bupropion hydrochloride sustained-release capsule, blood concentration is changed stably, after everyday medicine taking frequency is reduced, occurrence rate of adverse reaction is reduced obviously, and compliance of a patient is improved.

Description

technical field [0001] The invention relates to a capsule and a preparation method thereof, in particular to a bupropion hydrochloride sustained-release capsule and a preparation method thereof Background technique [0002] Bupropion hydrochloride is an aminoketone drug that has a weak inhibitory effect on the uptake of norepinephrine, 5-hydroxytryptamine (5-HT) and dopamine. g of bupropion hydrochloride sustained-release tablets can also be used as a smoking cessation preparation. However, excessive application of ordinary tablets may lead to epilepsy (the incidence rate is about 0.4%). However, the existing sustained-release tablets are skeleton sustained-release tablets made of high viscosity or water-insoluble materials, which are easily disturbed by various factors in the body, especially affected by the peristaltic rate of the gastrointestinal tract, and individual differences are obvious, resulting in curative effect. bad. Contents of the invention [0003] The t...

Claims

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Application Information

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IPC IPC(8): A61K9/60A61K31/137A61P25/24A61P25/34
Inventor 雷迪克
Owner 上海爱的发制药有限公司
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