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Morinda officinalis oligosaccharides and preparation method therefor

A technology of Morinda officinalis oligosaccharide and Morinda officinalis, applied in the field of medicine, can solve the problems of complex preparation process and low yield.

Active Publication Date: 2016-01-27
广州万正药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Guangzhou University of Traditional Chinese Medicine has studied the purification of total oligosaccharides from Morinda officinalis, but the preparation process is relatively complicated, requiring at least 7 specific steps, and the yield is not high

Method used

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  • Morinda officinalis oligosaccharides and preparation method therefor
  • Morinda officinalis oligosaccharides and preparation method therefor
  • Morinda officinalis oligosaccharides and preparation method therefor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0162] 500g of Morinda officinalis medicinal material, crushed into coarse powder, add 6 times the amount of water to extract three times, each time for 1h, combine the extracts, concentrate to 500mL, the relative density is about 1.2g / mL. Let cool, add 95% ethanol to ethanol concentration of 60%, let it stand overnight, filter, recover ethanol, concentrate to 250mL, relative density is about 1.4g / mL. Add water to dilute to 1L, add 100g activated carbon to absorb overnight, filter, and the filtrate is absorbed by D101 macroporous resin column, eluted with water for 4 column volumes, combined eluents, concentrated and then freeze-dried to obtain the total extract of Morinda officinalis oligosaccharides 217g, Morinda officinalis oligosaccharides 205g, including disaccharides 14.94g, trisaccharides 9.14g, tetrasaccharides 13.00g, pentasaccharides 12.98g.

Embodiment 2

[0164] 500g of Morinda officinalis medicinal material, crushed into coarse powder, added 7 times the amount of water to extract three times, 1.5h each time, combined the extracts, concentrated to 500mL, and the relative density was about 1.2g / mL. Let it cool, add 95% ethanol until the ethanol concentration is 65%, let stand overnight, filter, recover ethanol, concentrate to 250mL, and the relative density is about 1.4g / mL. Add water to dilute to 1L, add 150g activated carbon to absorb overnight, filter, and the filtrate is absorbed by D101 macroporous resin column, eluted with water for 5 column volumes, combined eluents, concentrated and freeze-dried to obtain the total extract of Morinda officinalis oligosaccharides 209g, Morinda officinalis oligosaccharides 207g, including disaccharides 18.63g, trisaccharides 14.49g, tetrasaccharides 18.62g, pentasaccharides 18.57g.

Embodiment 3

[0166]500g of Morinda officinalis medicinal material, crushed into coarse powder, added 8 times the amount of water to extract three times, 2 hours each time, combined the extracts, concentrated to 500mL, and the relative density was about 1.2g / mL. Let cool, add 95% ethanol to ethanol concentration of 70%, let it stand overnight, filter, recover ethanol, concentrate to 250mL, relative density is about 1.4g / mL. Add water to dilute to 1L, add 200g activated carbon to adsorb overnight, filter, and the filtrate is adsorbed by D101 macroporous resin column, eluted with water for 6 column volumes, combined eluents, concentrated and then freeze-dried to obtain the total extract of Morinda officinalis oligosaccharides 201g, Morinda officinalis oligosaccharides 161g, including 9.67g disaccharides, 8.05g trisaccharides, 8.05g tetrasaccharides, and 8.07g pentasaccharides.

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Abstract

The invention discloses morinda officinalis oligosaccharides and a preparation method therefor. The oligosaccharide content is 50-99%. The morinda officinalis oligosaccharides comprise dimers, trimers, tetramers, pentamers, hexamers, heptamers, octamers and nonamers. The morinda officinalis oligosaccharides has a function of ajdusting immunization. The preparation method can achieve industrialization production.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a Morinda officinalis oligosaccharide and a preparation method thereof. Background technique [0002] Morinda officinalis is a dicotyledonous Rubiaceae medicinal plant, and the part used as medicine is the underground dry root. The root of the medicinal material is cylindrical, slightly curved, varying in length, 1-2 cm in diameter, gray-yellow or gray-yellow-brown on the surface, some with a slight purple tinge, longitudinal wrinkles and deep horizontal stripes, and some constricted Or the bark is cut off horizontally to expose the xylem, shaped like chicken intestines. The quality is tough, the broken surface is uneven, the thickness of the skin is 5-7mm, lavender, and the diameter of the xylem is 2-4mm. Gas micro, bitter, slightly astringent. The traditional effects include tonifying kidney and strengthening yang, strengthening muscles and bones, and dispelling rheumatism. After re...

Claims

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Application Information

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IPC IPC(8): A61K36/746A61P37/02A61P25/24A61P9/00
Inventor 许舜军孙帅杨柳余捷婧许铮弟张和灿许艺镌陈志辉
Owner 广州万正药业有限公司
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