A kind of preparation method and application of cyclodextrin inclusion compound containing Ainaxiang extract
A cyclodextrin inclusion compound and extract technology, which is applied to medical preparations containing active ingredients, medical preparations without active ingredients, drug combinations, etc., can solve the problem of low active ingredient content, low stability, and low solubility and other problems, to achieve the effect of short preparation time, good stability and simple operation
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Embodiment 1
[0033] Example 1 Preparation method of moxa tablet β-cyclodextrin inclusion compound
[0034] Weigh 0.25 g of moxa tablets and put them into a small beaker, dissolve them with 2 ml of ethanol to prepare moxa tablets-ethanol solution, then weigh 1 g of β-cyclodextrin in a ratio of 1:4, put them in a mortar, add 20 ml Dissolve in distilled water, add moxa tablet-ethanol solution while grinding, and grind for 45 minutes; put the ground sample in the refrigerator (4°C) for 12 hours, take it out, filter it and dry it. The obtained clathrate was washed with ethyl acetate for 3 times, and the moxa tablets that were not clathrated were cleaned, and finally the washed samples were put into an oven to dry to obtain 1.17 g of moxa slices β-cyclodextrin clathrate , and the yield was 93.6%. As determined by gas chromatography, the content of L-borneol in the clathrate was 17.52%.
Embodiment 2
[0035] Example 2 Preparation method of mugwort powder β-cyclodextrin inclusion compound
[0036] Weigh 0.25 g of moxa powder and put it into a small beaker, dissolve it with 2 ml of ethanol to prepare moxa powder-ethanol solution, then weigh 1.5 g of β-cyclodextrin in a ratio of 1:6, put it in a mortar, add 25 ml Dissolve in distilled water, add moxa powder-ethanol solution while grinding, and grind for 45 minutes; put the ground sample in the refrigerator (4°C) for 15 hours, take it out, and dry it after vacuum filtration. The inclusion compound was washed with ethyl acetate for 3 times, and the moxa powder that was not included was cleaned. Finally, the washed sample was put into an oven to dry, and 1.3599 g of the inclusion compound of moxa powder β-cyclodextrin was obtained. The yield was 90.66%. As determined by gas chromatography, the content of L-borneol in the clathrate was 15.23%.
Embodiment 3
[0037] Example 3 Preparation method of Aina sesame oil β-cyclodextrin inclusion compound
[0038] Weigh 0.25 g of Aina sesame oil into a small beaker, dissolve it with 2 ml of ethanol to prepare a Aina sesame oil-ethanol solution, then weigh 2 g of β-cyclodextrin in a ratio of 1:8, put it in a mortar, add Dissolve in 35 ml of distilled water, add Aina sesame oil-ethanol solution while grinding, and grind for 60 min; put the ground sample in the refrigerator (4°C) for a period of time, take it out, and vacuum filter it. After drying, the obtained clathrate was washed with ethyl acetate for 3 times, and the Aina sesame oil that was not included was cleaned, and finally the cleaned sample was put into an oven to dry, and the Aina sesame oil β-cyclodextrin package was obtained. The compound was 1.646 g, and the yield was 82.30%. The content of L-borneol in the clathrate was determined by gas chromatography to be 14.24%.
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